Title: Neurostimulation In Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)

Principal Investigator: Tara Brinkman, PhD, St. Jude Children’s Research Hospital, Memphis, Tennessee   

Description: To date, there have been few studies that focus on interventions to improve neurocognitive outcomes in long-term survivors of acute lymphoblastic leukemia (ALL). Researchers are aware, however, that long-term survivors of ALL are at risk for neurocognitive impairment, particularly as it pertains to executive functioning. A promising technique for cognitive enhancement is transcranial direct current stimulation (tDCS), which directly stimulates specific brain regions responsible for cognitive processes and seeks to activate functional networks similar to those activated during cognitive training.

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Researchers are seeking to randomly assign eligible participants to receive 1 mA tDCS over the left dorsolateral prefrontal cortex or placebo/sham for 20 minutes. All participants will receive home-based computerized cognitive training. Participants will complete tDCS paired with cognitive training 2 times per week for 6 months.

The primary outcome of the study is to evaluate the efficacy of home-based tDCS combined with remote cognitive training on direct testing of executive function in survivors of ALL.

Eligible participants must have completed treatment for ALL at St Jude Children’s Research Hospital and have be younger than 21 years at diagnosis. Participants must also be enrolled in the St. Jude Lifetime Cohort Study. To review the complete inclusion and exclusion criteria please refer to the reference.

Status: Recruiting

This study is sponsored by St. Jude Children’s Research Hospital.


Clinicaltrials.gov. Neurostimulation In Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALL). NCT04007601. Accessed June 17, 2021.