According to new findings presented at the American Association for Cancer Research's (AACR) New Horizons in Cancer Research: Harnessing Breakthroughs - Targeting Cures in Shanghai, China, a new drug compound currently known as VAL-083 was shown to be superior to cisplatin for the treatment of non-small cell lung cancer (NSCLC).
The results demonstrated that VAL-083 is superior to cisplatin in tumors that are either sensitive or resistant to tyrosine kinase inhibitors (TKI), and it was found to have a synergistic effect when combined with cisplatin.
VAL-083 (dianhydrogalactitol) is the first agent in a class of alkylating agents that have a novel cytotoxic mechanism. The drug has demonstrated clinical activity in various types of cancers, including central nervous system tumors, solid tumors, and hematologic cancers. VAL-083 is approved for the treatment of lung cancer and chronic myelogenous leukemia (CML) in China. In the United States, VAL-083 is in a phase 1/2 clinical trial to study its efficacy in the treatment of glioblastoma multiforme.
NSCLC is typically treated with either a TKI, such as gefitinib, or a platinum-containing regimen. Despite improved outcomes seen with the use of TKIs, there are not many options for patients with TKI resistance.
DelMar Pharmaceuticals, Inc., a clinical-stage oncology company, today announced the presentation of promising new data supporting the activity of its lead drug compound, VAL-083, in the treatment of non-small cell lung cancer (NSCLC) at the AACR’s New Horizons in Cancer Research: Harnessing Breakthroughs – Targeting Cures. The conference takes place October 9th to 12th in Pudong, Shanghai.
“The data presented today showed that VAL-083 is superior to cisplatin in both tumor models that are sensitive and resistant to tyrosine kinase inhibitors and has synergistic effect in combination with cisplatin,” said Jeffrey Bacha, president and CEO of DelMar Pharmaceuticals. “This data suggests important clinical and market potential of VAL-083 in non-small cell lung cancer.”