The interaction observed between single nucleotide polymorphisms (SNPs) and asbestos exposure correlated to increased lung cancer risk among MIRLET7BHG carriers, according to an article published online in the journal Cancer Epidemiology, Biomarkers & Prevention.
The study included 833 Caucasian cases and 739 Caucasian control participants. The authors identified SNPs with gene-asbestos interaction effects using a genome-wide association study (GWAS).
In groups with GWAS and asbestos exposure data (1,548 cases and 1,527 controls), in silico replication was conducted, followed by de novo genotyping to replicate the results from step one (1,539 cases and 1,761 controls).
Results showed a significant increase in lung cancer risk in participants who were variant allele(s) carriers of MIRLET7BHG (MIRLET7B host gene at 22q13.31) polymorphisms rs13053856, rs11090910, rs11703832, and rs12170325 [P<5×10-7 by likelihood ratio test; df=1].
The authors observed that among the participants who were variant allele(s) carriers, each unit increase in the natural log-transformed asbestos exposure score was associated with age-, sex-, smoking status- and center-adjusted ORs of 1.34(95% CI: 1.18, 1.51), 1.24(95% CI: 1.14, 1.35), 1.28(95% CI: 1.17, 1.40), and 1.26(95% CI: 1.15, 1.38), respectively for lung cancer risk.
Interaction between SNPs and asbestos exposure correlated to increased lung cancer risk in MIRLET7BHG carriers
↵*Corresponding Author: David C. Christiani, Department of Environmental Health, Harvard School of Public Health, Harvard University, 665 Huntington Avenue, Bldg I-1407, Boston, MA, 02115, United States dchris{at}hsph.harvard.edu Background:Occupational asbestos exposure has been found to increase lung cancer risk in epidemiological studies. Methods:We conducted an asbestos exposure-gene interaction analyses among several Caucasian populations who were current or ex-smokers.
From cebp.aacrjournals.org
