Nivolumab monotherapy and combined with ipilimumab shows encouraging response and survival rates among patients with recurrent small cell lung cancer (SCLC) in the CheckMate-032 study, according to an announcement by Bristol-Myers Squibb.1

CheckMate-032 is an ongoing phase 1/2 open-label trial evaluating the safety and efficacy of different doses and schedules of single-agent nivolumab and nivolumab plus ipilimumab in advanced or metastatic solid tumors.

The SCLC cohort of CheckMate-032 included 217 patients with disease progression after 1 or more prior lines of treatment, including a first-line platinum-based chemotherapy regimen. In this analysis, treatment with nivolumab 1 mg/kg plus ipilimumab 3 mg/kg was associated with a confirmed objective response rate of 25% (95% CI, 15-37), including 3 complete responses and 21 partial responses.

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Eleven percent of patients treated with nivolumab monotherapy achieved an objective response rate. Investigators observed responses regardless of platinum sensitivity or prior lines of therapy.

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Median duration of response was 11.7 months (95% CI, 4.0-not reached) in the combination arm and not reached in the single-agent nivolumab arm. The estimated 2-year overall survival rate was 30% with the combination and 17% with nivolumab alone.

No new safety signals were observed with longer follow-up duration.


  1. Opdivo (nivolumab) alone or combined with Yervoy (ipilimumab) shows encouraging response and survival rates in recurrent small cell lung cancer, from phase 1/2 study CheckMate -032. Bristol-Myers Squibb website. Published December 6, 2016. Accessed December 19, 2016.