Limitation of the Study

Our study is retrospective, limiting the measurement of some key statistics. As a one-center study, the generalization of the results is restricted. Most of the patients with advanced stage were only diagnosed with fine needle aspiration or small biopsies, and thus limited tissue was available for further studies.


Gemcitabine therapy, ERCC1 negativity and treatment with platinum therapy, ECOG PS 0 or 1, and female gender correlated with improved overall survival in patients with advanced NSCLC.

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Author Contributions

Conceived and designed the experiments: NK, MS, AM. Analyzed the data: MR. Wrote the first draft of the manuscript: NK, AZ, MS, MA. Contributed to the writing of the manuscript: PP, SS, HB, NP, MA. Agree with manuscript results and conclusions: NK, MS, AZ, PP, SS. Jointly devel­oped the structure and arguments for the paper: PP, SS, AZ, MR, AM. Made critical revisions and approved final version: NK, MS, HB, NP. All authors reviewed and approved of the final manuscript.

Nagla A. Karim1, Hai Bui2, Peterson Pathrose3, Sandra Starnes3, Ninad Patil4, Mahmoud Shehata1, Ahmed Mostafa5, MB Rao6, Ahmad Zarzour7, and Marshall Anderson8

1Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA. 2Department of Pathology, Cincinnati VA Medical Center, Cincinnati, OH, USA. 3Divison of Thoracic Surgery, Department of Surgery, University of Cincinnati, Cincinnati, OH, USA. 4Department of Pathology, Mount Sinai Medical Center, New York, NY, USA. 5Division of Pulmonary, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA. 6Division of Environmental Health, University of Cincinnati, Cincinnati, OH, USA. 7Internal Medicine Department, Cleveland Clinic Foundation, Cleveland, OH, USA. 8Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. 


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Source: Clinical Medicine Insights: Oncology