Chidamide demonstrates significant single-agent activity and manageable toxicity in the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL), according to a recent study published online ahead of print in the Annals of Oncology.
Chinese researchers led by Yuan-Kai Shi, MD, PhD, of the Chinese Academy of Medical Sciences & Peking Union Medical College looked at 79 patients in a Chinese population with PTCL histology as part of a phase II study to examine the effects of chidamide, a novel oral benzamide class of histone deacetylase (HDAC) inhibitor.
Patients received chidamide orally twice a week, and primary endpoint was the overall response rate.
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Overall response rate was found to be 28 percent, including 14 percent of patients who had complete or unconfirmed complete response. Median progression-free survival was 2.1 months while overall survival was 21.4 months.
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Among the subtypes of PTCL observed, 13 percent who had angioimmunoblastic T-cell lymphoma were found to have higher overall as well as complete/unconfirmed complete response rate.
The results of the study “led to China Food and Drug Administration approval of chidamide in this indication,” according to the authors.
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