Abstract: A 61-year-old man with relapsing-remitting multiple sclerosis developed extranodal large B-cell lymphoma of the stomach following monthly natalizumab infusions for 6 years.

Development of lymphoproliferative disorders increases with chronic use of immunosuppression. Cases of primary central nervous system lymphoma as well as one case of peripheral T-cell lymphoma have previously been reported with natalizumab use.

Given the absence of a known association between multiple sclerosis and extranodal presentations of diffuse large B-cell lymphoma, a causal association with natalizumab administration cannot be excluded.

Keywords: natalizumab, multiple sclerosis, Non-Hodgkin lymphoma of the stomach.


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Citation: Law et al. Non-Hodgkin Lymphoma of the Stomach in a Patient Treated with Natalizumab. Clinical Medicine Insights: Oncology 2015:9 61–63 doi: 10.4137/CMO.S27142.

Received: April 02, 2015. ReSubmitted: June 07, 2015. Accepted for publication: June 09, 2015.

Academic editor: William C. S. Cho, Editor in Chief

Type: Case Report

Funding: Authors disclose no funding sources.

Competing Interests: Authors disclose no potential conflicts of interest.

Correspondence: harris.naina@utsouthwestern.edu

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