Minimal residual disease (MRD)-negative status among patients with newly-diagnosed multiple myeloma after treatment may be associated with long-term survival, according to a study published in JAMA Oncology.1

Researchers led by Nikhil Munshi, MD, of the Dana-Farber Cancer Institute in Boston, MA, evaluated 21 studies through Medline, which provided data on the impact of MRD status on progression-free and overall survival.

Information on patient characteristics, treatment, MRD assessment, and outcomes, were gathered. Data were adjusted to allow for different proportions of patients with MRD across the studies.

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There were 12 studies with data on impact of MRD on overall survival, and 14 for progression-free survival. MRD-negative status was associated with better progression-free survival, particularly in studies of patients who had achieved conventional complete response.

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Overall survival was favorable among MRD-negative patients, as well as among patients with complete response.


  1. Munshi NC, Avet-Loiseau H, Rawstron AC, et al. Association of minimal residual disease with superior survival outcomes in patients with multiple myeloma: a meta-analysis. JAMA Oncol. 2016 Sep 15. doi:10.1001/jamaoncol.2016.3160 [Epub ahead of print]