Circulating Tumor Plasma Cells Predict Progression in Myeloma
The presence of circulating tumor plasma cells by next-generation flow independently predicted disease progression after treatment in patients with multiple myeloma.
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Multiple Myeloma News
Chromosomal Aberrations in Clones Seem Prognostic in Smoldering Myeloma
The detection of chromosomal aberrations in the main clone appear to have prognostic significance in patients with smoldering myeloma.
MPN-Directed Therapy Does Not Alter Timing of Clinical Manifestations of Splanchnic Vein Thrombosis
A retrospective analysis sought to determine the association between myeloproliferative neoplasms, MPN-directed therapy, and development of splanchnic vein thrombosis.
Antibiotic Prophylaxis Reduced Febrile Episodes, Death in Newly Diagnosed Myeloma in TEAMM Trial
The TEAMM trial sought to assess time to first febrile episode or death from all causes in patients with newly diagnosed myeloma who received antibiotic prophylaxis vs those who did not.
Potential Link Between Tumor Necrosis Factor-α and Peripheral Neuropathy Observed With Bortezomib Treatment in Multiple Myeloma
Researchers explored a possible link between TNF-α and peripheral neuropathy in patients with MM treated with bortezomib.
Outcomes With Plerixafor Following Autologous Stem Cell Transplantation for Multiple Myeloma
The addition of plerixafor to treatment following transplantation may not enhance lymphocyte recovery in patients with multiple myeloma.
Exploring High Levels of Uncertainty Regarding HCT in Myeloma, Lymphoma, Leukemia
Uncertainty is defined in this study as “the inability to give sense or meaning to the processes or situations that have to do with medical conditions.”
Outpatient ASCT for Myeloma Found Safe, Effective With Proper Patient Selection
Only about one-third of patients required hospital admission.
Bone Marrow Infiltrating Lymphocytes Have Unique Characteristics
These characteristics may account for enhanced antitumor efficacy in multiple myeloma.
Response-Adapted Intensification in Multiple Myeloma After Suboptimal Response to Induction
Patients who received intensification treatment experienced longer progression-free survival compared with patients receiving maintenance treatment.
Triple-Drug Induction Therapy Yields Sustained Responses in Multiple Myeloma
Patients receiving the 3-drug treatment experienced increasing rates of complete response and measurable residual disease from induction through consolidation.
Hematologic Scoring System Predicts Survival in Multiple Myeloma
A hematologic score based on specific blood parameters was evaluated for its potential to predict survival in patients with newly diagnosed multiple myeloma.
Treosulfan May Offer a New Standard for Prehematopoietic Stem Cell Transplantation Conditioning
Patients receiving treosulfan and fludarabine experienced improved event-free and overall survival compared with patients receiving busulfan and fludarabine.
Racial Disparities Affect Myeloma Treatment, Though Survival May Be Similar
Time to initiation of therapy was significantly longer for black and Hispanic patients compared with white patients.
Adherence to Other Oral Medications Declines Following Introduction of Oral Oncolytics
This study assessed levels of adherence to antihypertensive, lipid-lowering, and antidiabetic therapy in patients initiating oral oncology therapy for a hematologic cancer.
Defects in Primary Hemostasis May Cause Bleeding in Multiple Myeloma
Prolonged closure time and defects in von Willebrand factor were identified as risk factors for bleeding complications patients with multiple myeloma.
CAR-T Therapy May Be More Effective When Administered Earlier in the Multiple Myeloma Treatment Continuum
A critical step in the preparation of autologous CAR-T therapy is the ex vivo proliferation of T cells from samples obtained from leukapheresis.
Analysis Determines Cost Effectiveness of Various Treatment Strategies for Multiple Myeloma
In this systematic review, researchers analyzed the cost effectiveness of various treatments and treatment lines for multiple myeloma.
Dental Issues Can Delay Treatment for Patients With Multiple Myeloma
A case series study demonstrated the importance of timely, preventive dental assessment for patients with multiple myeloma.
Findings Support Routine Clinical Use of Molecular MRD Assays in Multiple Myeloma
The prognostic value of MRD in the setting of multiple myeloma has been previously demonstrated, although questions remain regarding MRD detection methodology.
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