Polygenic Score May Identify Kids, AYAs With AML Who Need Augmented Therapy
A low score was associated with poor outcomes in patients who received standard induction therapy.
Pediatric Cancer News
PEDIATRIC CANCER ADVISOR
Pediatric Cancer News
Inotuzumab Ozogamicin Deemed Effective in Heavily Pretreated B-ALL
The estimated event-free survival rate was 28.6% at 2 years and 19.6% at 3 years.
Psychological Distress More Likely in Young Adult Cancer Survivors
Roughly 11% of AYA cancer survivors reported psychological distress 20 years or more after their cancer diagnosis.
Maternal Hormonal Contraception, CNS Tumors Not Linked in Children
No significant association was seen between maternal hormonal contraception use and CNS tumors in children younger than 20 years.
Reinfusion of CAR-T Cells May Prevent Relapse in Acute Lymphoblastic Leukemia
The findings of this study prompted a change in clinical practice.
Adding Monoclonal Antibody to Induction Could Be New Standard Care for High-Risk Neuroblastoma
Results from a phase 2 trial, if validated in a larger study, may be practice-changing, according to researchers.
Study Reveals ‘Best Biomarker to Date’ for Predicting Relapse After CAR T-Cell Therapy
Minimal residual disease in the bone marrow, detected via next-generation sequencing, was “highly predictive” of relapse after treatment with tisagenlecleucel.
Blinatumomab Plus Chemo: ‘New Standard’ for Some Low-Risk Patients With First Relapse of B-ALL
Blinatumomab improved disease-free and overall survival.
FDA Approves Rituxan Plus Chemotherapy for Certain Pediatric Hematologic Cancers
The approval was based on data from the open-label, randomized phase 3 Inter-B-NHL Ritux 2010 trial.
Caregivers of Childhood Cancer Survivors Concerned About COVID-19 Vaccines
Concerns, expressed early in the rollout, included lack of safety and efficacy data, particularly in children with cancer.
Exposure to 17-OHPC in Utero Linked to Cancer Risk in Offspring
The risk of any cancer increased in association with first-trimester exposure.
Parents Report Challenging Relationships With Pediatric Oncology Clinicians
Asian parents were more likely to report challenging relationships.
Regimen May Be Beneficial as Palliative Care for Children, Young Adults With Solid Tumors
Stable disease was observed in 51.3% of patients.
Factors That Impact HRQOL in Pediatric Patients With Chronic Myeloid Leukemia
Patients’ age, sex, and treatment-related symptoms, as well as mothers’ education level, were significantly associated with HRQOL.
CSF-Derived cfDNA Can Be Surrogate for MRD in Medulloblastoma
Researchers were able to detect measurable residual disease at baseline in 64% of patients.
Suicide Risk Up for Long-Term Survivors of Childhood Cancer
The suicide risk was significantly elevated for survivors alive beyond the age of 28 years.
‘Best Survival to Date’ in Phase 3 Trial of Ewing Sarcoma
The 5-year overall survival rate was 87%.
Assessing Priorities in End-of-Life Care for Children With Cancer
In a study of end-of-life care for children with cancer, healthcare resource use measures were seen as less important than were patient-reported outcomes.
Online Calculator May Predict Treatment-Related Hearing Loss in Children With Cancer
The dose of chemotherapy and radiation, patient age, and timing of treatment were all associated with the risk of severe hearing loss.
Genomic Sequencing in Pediatric Cancer: For Every Patient at Every Relapse
More than one-third of tumors sequenced carried a high mutation burden.
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