Early Radiotherapy Preserves Vision in Certain Children With Glioma
Early radiotherapy may preserve visual acuity for certain children with sporadic optic pathway/hypothalamic gliomas.
Pediatric Cancer News
PEDIATRIC CANCER ADVISOR
Pediatric Cancer News
RB-RECIST Criteria May Improve Retinoblastoma Management: An Interview With Jesse L. Berry, MD
In an international, multicenter collaboration, experts modified the RECIST criteria for use as objective endpoints in clinical trials of retinoblastoma therapies.
Extended Induction Chemotherapy Does Not Improve Survival in High-Risk Neuroblastoma
Researchers found that the therapy did not improve EFS or OS in high-risk patients and also led to an increase in toxic side effects.
Durable B-ALL Control With Allogeneic Transplant After CAR T-Cell Therapy
Investigators sought to assess outcomes following CD19 CAR T-cell therapy in children and young adults who underwent alloHSCT for B-cell acute lymphoblastic leukemia.
Risk Factors for Pediatric Hemorrhagic Cystitis Following HCT
Investigators conducted a study to determine the incidence and clinical course of BK virus hemorrhagic cystitis in children undergoing hematopoietic cell transplantation.
Youth With Cancer May Need Parental Help When Deciding Sperm Banking
After a cancer diagnosis, male adolescents may be unprepared to make decisions about fertility preservation independently and instead need parental involvement.
Socioeconomics Tied to Cognitive Function in Survivors of Childhood Brain Tumors
Researchers hope their findings could lead to targeted interventions to improve cognitive outcomes in pediatric brain tumor survivors from families with low socioeconomic status.
Blinatumomab Improves Outcomes in Children With High-Risk B-ALL
A multicenter, randomized, phase 3 trial compared blinatumomab with intensive multidrug consolidation chemotherapy in children with high-risk, first-relapse B-cell ALL.
COVID-19 Pandemic Has Affected Pediatric Cancer Care Worldwide
Although the number of reported cases of SARS-CoV-2 infection among pediatric patients with cancer has been low, the effect of the pandemic on cancer care services for this population is not well understood.
NCCN Releases First Practice Guidelines for Wilms Tumor
New NCCN guidelines for Wilms tumor contain up-to-date information on screening, diagnosis, risk stratification, and treatment for this rare childhood renal cancer.
Pediatric Cancer Survivors and Diabetes: What Are the Risks?
Diabetes and metabolic syndrome represent two of the most common long-term complications in survivors of childhood cancer.
Ruxolitinib Yielded High Response Rate in Children With Refractory GVHD
Ruxolitinib, a selective nonreceptor Janus kinase 1/2 inhibitor shown to have activity in adults with refractory GVHD, was studied in pediatric patients.
Analysis Shows Disparities in Care Extend to Imaging Studies in Pediatric Patients
An evaluation of a large dataset sought to determine use of imaging studies in children treated in children’s hospital emergency departments.
Light-Based Therapy Shows Promise in Treating Mucositis in Pediatric Cancer Patients
Photobiomodulation shows impressive results in pretrial use for treatment and prevention of treatment-associated mucositis in pediatric patients.
Pediatric Tumors Carry Higher NTRK Mutation Burden Than Adult Tumors
Investigators assessed the frequency, fusion partners, and clinical course in pediatric patients with NTRK fusion–positive tumors.
Increased Mortality Risk in Patients With Cancer Experiencing the Death of a Child
Population-based study evaluated survival outcomes for patients with cancer diagnosed over a 41-year period.
Evolving Incidence Trends in AYA Cancers
Cancer incidence trends across 41 countries demonstrated sharp increases and decreases in certain cancer types over the last 15 years.
Role Exists for Re-Irradiation of Older Patients with Recurrent Glioma
Survival from time of recurrence was similar to that seen in younger patients.
ctDNA Methylation May Identify Pediatric Medulloblastoma
Pediatric medulloblastoma demonstrated a distinct methylation profile that could identify the disease and monitor treatment response.
Extensive Molecular Characterization Uncovers Actionable Alterations in Many High-Risk Pediatric Cancers
As part of the Zero Childhood Cancer Program, high-risk pediatric tumors were characterized by whole-genome sequencing, RNA sequencing, and methylation profiling.
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