The tool proved most effective in survivors of solid tumors or central nervous system tumors and in patients not exposed to radiation during treatment of their primary malignancy.
The cumulative incidence of cisplatin-induced hearing loss was 75% in patients age 5 and younger, compared with 48% in older patients.
About 20% of pediatric cancer patients who developed COVID-19 had severe or critical disease.
Researchers found a “strong genetic basis” for racial differences in survival.
Adding temozolomide to vincristine and irinotecan improved survival.
Researchers studied a total of 1903 cases of pediatric melanoma and patients were 54.4% female, the mean age was 12.4 years, and 89.8% were White.
Response rates were highest with MIBG plus vorinostat.
Patients with stage II or IV disease did not fare as well as patients with stage I or III disease.
Testing revealed therapeutically relevant information for some patients.
The rCOJEC regimen was less toxic than the MSKCC-N5 regimen.
Integrating molecular profiling into current clinical stratification could improve outcomes in rhabdomyosarcoma, according to researchers.
Frail survivors of childhood cancer experienced greater neurocognitive decline.
Children treated for neuroblastoma developed myeloid neoplasms with specific platinum chemotherapy-associated mutation signatures.
Looking at single year of age revealed “substantial” differences.
Early radiotherapy may preserve visual acuity for certain children with sporadic optic pathway/hypothalamic gliomas.
In an international, multicenter collaboration, experts modified the RECIST criteria for use as objective endpoints in clinical trials of retinoblastoma therapies.
Researchers found that the therapy did not improve EFS or OS in high-risk patients and also led to an increase in toxic side effects.
Investigators sought to assess outcomes following CD19 CAR T-cell therapy in children and young adults who underwent alloHSCT for B-cell acute lymphoblastic leukemia.
Investigators conducted a study to determine the incidence and clinical course of BK virus hemorrhagic cystitis in children undergoing hematopoietic cell transplantation.
After a cancer diagnosis, male adolescents may be unprepared to make decisions about fertility preservation independently and instead need parental involvement.