Pediatric Cancer News
Population-based study evaluated survival outcomes for patients with cancer diagnosed over a 41-year period.
Cancer incidence trends across 41 countries demonstrated sharp increases and decreases in certain cancer types over the last 15 years.
Survival from time of recurrence was similar to that seen in younger patients.
Pediatric medulloblastoma demonstrated a distinct methylation profile that could identify the disease and monitor treatment response.
As part of the Zero Childhood Cancer Program, high-risk pediatric tumors were characterized by whole-genome sequencing, RNA sequencing, and methylation profiling.
The prospective study showed that after 4 years, complete resection of the tumor for children with local lymph node involvement (no metastasis) delivered an overall survival rate of 91.4%.
The FDA and EMA expressed the need for trial sponsors to coordinate their submissions of initial pediatric study plans and pediatric investigation plans for new oncology drugs.
2007 to 2016 saw increase in overall cancer incidence in all age groups, mainly driven by thyroid cancer.
A large cross-sectional cohort study investigated the relationship between hearing loss and measures of neurocognition in survivors of childhood cancers.
Studies suggest that the majority of pediatric patients with cancer and COVID-19 experience mild disease — rather than severe disease — as a result of infection with the novel virus.
The risk of disease for children with cancer may be similar to the risk for children in the general population.
Adolescent and young adult cancer patients underrepresented in clinical trials.
Burnout rates among pediatric hematology/oncology fellows may be influenced by less patient-centered care and less humanistic practice.
The application is supported by data from 2 pivotal open-label, randomized phase 3 trials (SIOPEL 6 and ACCL0431), which compared the efficacy of sodium thiosulfate plus cisplatin to cisplatin alone for the prevention of cisplatin-induced hearing loss.
An analysis of previously approved novel anticancer agents estimates that more than 78% would have met the RACE for Children Act criteria for pediatric testing.
The authors of this article emphasized the importance of actively involving a diverse group of interdisciplinary team members in the psychosocial care of these patients.
Medical and ethical considerations are discussed, including in cases of conflict between parent, child.
Risk for coronary artery disease significantly decreased for survivors with diagnosis in 80s, 90s versus 70s.
At 3 days before a bloodstream infection, mcfDNA sequencing correctly predicted 12 of the 16 observed episodes.
Of all types of fertility treatment examined, the only one that significantly increased the risk of cancer in children was frozen embryo transfer.