THURSDAY, Nov. 21, 2013 (HealthDay News) — In men with prostate cancer, a low-fat fish oil diet is associated with lower serum levels of pro-inflammatory molecules, changes in serum levels of omega fatty acids, and a lower measure of cancer growth, compared with a Western diet, according to a study published online Oct. 29 in Cancer Prevention Research.

Colette Galet, Ph.D., from the University of California in Los Angeles, and colleagues compared serum levels of fatty acids and pro-inflammatory eicosanoids as well as cell cycle progression score in men with prostate cancer who had been randomly assigned to a low-fat fish oil diet (20 percent of calories from fat) or a Western diet (40 percent of calories from fat) for four to six weeks.

The researchers found that men on the fish oil diet had significantly lower serum levels of omega-6 fatty acids and 15(S)-hydroxyeicosatetraenoic acid (HETE), higher serum levels of omega-3 fatty acids, and a significantly lower cell cycle progression score compared with men on a Western diet. Leukotriene B4 levels were similar in both groups.

Continue Reading

“In conclusion, a low-fat fish oil diet resulted in decreased 15(S)-HETE levels and lower cell cycle progression score relative to a Western diet,” Galet and colleagues write.

The study was the result of work supported with resources and the use of facilities at Myriad Genetics Laboratories.

Full Text (subscription or payment may be required)