Metastasis-directed therapy (MDT) for oligometastatic castration-sensitive prostate cancer (omCSPC) offers a long-term benefit in terms of progression-free survival (PFS), according to a study published in the Journal of Clinical Oncology. This benefit was most pronounced among patients with tumors harboring high-risk genetic mutations.
In an analysis of pooled data from the prospective STOMP (ClinicalTrials.gov Identifier: NCT01558427) and ORIOLE (ClinicalTrials.gov Identifier: NCT02680587) trials, researchers found that MDT was associated with a 56% reduction in the risk of disease progression compared with observation after a median follow-up of 52 months. The median PFS — the study’s primary endpoint — was 11.9 months with MDT and 5.9 months with observation.
Among patients with high-risk mutations, MDT was associated with a 95% lower risk for disease progression. In this group, the median PFS was 7.5 months among MDT recipients and 2.8 months among those who underwent observation.
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In the MDT cohort, patients without high-risk mutations had a significantly longer median PFS compared with patients who had these mutations (13.4 vs 7.5 months).
“Although more follow-up is needed, the encouraging PFS report here suggests that, in appropriately selected patients, MDT without systemic therapy might be a reasonable option upfront in well-informed patients wishing to avoid side effects of androgen deprivation,” the researchers wrote.
The STOMP and ORIOLE trials compared MDT (stereotactic ablative radiation) and observation in patients with omCSPC. The researchers defined omCSPC as the presence of 3 or fewer sites of metastases. These studies previously demonstrated that MDT prolonged androgen deprivation-free survival and PFS.
For their analysis, the researchers included 116 patients (62 from STOMP and 54 from ORIOLE). The team defined high-risk mutations as pathogenic somatic mutations in ATM, BRCA1/2, Rb1, or TP53.
The researchers said it is notable that the PFS beyond 4 years was 15% to 20% with MDT regardless of mutation status, “and thus, a sizable proportion of patients will experience durable response to therapy.”
Reference
Deek MP, van der Eecken K, Sutera P, et al. Long-term outcomes and genetic predictors of response to metastasis-directed therapy versus observation in oligometastatic prostate cancer: Analysis of STOMP and ORIOLE trials. J Clin Oncol. Published online August 24, 2022. doi:10.1200/JCO.22.00644
This article originally appeared on Renal and Urology News
