(HealthDay News) — Researchers have identified 9 novel prostate cancer risk variants in men of African ancestry. The findings were published in European Urology.
The researchers conducted a meta-analysis of 10 genome-wide association studies including 19,378 patients with prostate cancer and 61,620 control individuals of African ancestry to discover common genetic variants contributing to the risk of prostate cancer.
The researchers identified 9 novel susceptibility loci for prostate cancer, 7 of which were only found or were more common in men of African ancestry.
A multiancestry polygenic risk score (PRS) of 278 risk variants was associated with prostate cancer risk in African ancestry studies (odds ratios >3 and >5 for men in the top PRS decile and percentile, respectively). Men in the top PRS decile had a significantly higher risk of aggressive prostate cancer compared with those in the 40% to 60% PRS category (odds ratio, 1.23).
“This study demonstrates the importance of large-scale genetic studies in men of African ancestry for a better understanding of PCa [prostate cancer] susceptibility in this high-risk population and suggests a potential clinical utility of PRS in differentiating between the risks of developing aggressive and nonaggressive disease in men of African ancestry,” the researchers wrote.
Abstract/Full Text (subscription or payment may be required)