Higher total and central adiposity are associated with an increased risk of death from prostate cancer, according to a research published in BMC Medicine.
Researchers found that increases in waist-to-hip ratio, body mass index (BMI), waist circumference, and total body fat percentage were associated with increases in the risk of prostate cancer death.
To discover these associations, the researchers conducted a prospective study of patients in the UK Biobank and included data from this study in a meta-analysis.
The prospective study included 218,237 patients, 661 of whom died from prostate cancer. Increases in most measures of adiposity were associated with an increased risk of prostate cancer death.
Hazard ratios (HRs) for prostate cancer death were 1.07 for every 5 kg/m2 increase in BMI, 1.07 for every 0.05 increase in waist-to-hip ratio, 1.06 for every 10 cm increase in waist circumference, and 1.00 for every 5% increase in total body fat percentage.
In the meta-analysis, increases in all measures of adiposity were associated with an increased risk of prostate cancer death.
The meta-analysis included 19 studies reporting on BMI. There were 19,633 prostate cancer deaths in these studies, and the HR for dying from prostate cancer was 1.10 for every 5 kg/m2 increase in BMI.
There were 6 studies on waist circumference and 3181 deaths in these studies. The HR for prostate cancer death was 1.07 for every 10 cm increase in waist circumference.
There were 3 studies reporting on waist-to-hip ratio and 1639 deaths in these studies. The HR for prostate cancer death was 1.06 for every 0.05 increase in waist-to-hip ratio.
There were 2 studies reporting on body fat percentage and 670 deaths in these studies. The HR for prostate cancer death was 1.03 per 5% increase in total body fat percentage.
“Overall, we found that men with higher total and central adiposity had similarly higher risks of prostate cancer death, which may be biologically driven and/or due to differences in detection,” the researchers wrote. “In either case, these findings support the benefit for men of maintaining a healthy body weight.”
Perez-Cornago A, Dunneram Y, Watts EL, Key TJ, Travis RC. Adiposity and risk of prostate cancer death: A prospective analysis in UK Biobank and meta‑analysis of published studies. BMC Med. Published online May 5, 2022. doi:10.1186/s12916-022-02336-x