Type 2 diabetes is independently associated with an increased risk of renal cell carcinoma in women, but not men, according to a new study published in Diabetes Care.
In a study of 117,570 women in the Nurses’ Health Study (NHS) and 48,866 men in the Health Professionals Follow-up Study (HPFS), Rebecca E. Graff, ScD, of the Harvard T. H. Chan School of Public Health in Boston, and colleagues found that women with type 2 diabetes had a significant 1.5-fold increased risk of RCC compared with non-diabetic women in multivariate analysis. Women with type 2 diabetes for 5 years or less had a significant 2-fold greater risk of RCC compared with non-diabetic women; women with type 2 diabetes for more than 5 years were not at significantly elevated risk of RCC, the investigators reported.
Among men, type 2 diabetes was not significantly associated with RCC risk.
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NHS and HPFS participants were followed up from 1976 and 1986, respectively, through 2014.
The investigators confirmed 418 RCC cases, including 120 fatal cases, during 38 years of follow-up in the NHS, and 302 RCC cases during 28 years of follow-up in the HPFS.
Reference
- Graff RE, Sanchez A, Tobias DK, et al. Type 2 diabetes in relation to the risk of renal cell carcinoma among men and women in two large prospective cohort studies. Diabetes Care. 2018; published online ahead of print.
This article originally appeared on Renal and Urology News
