Preoperative proteinuria is a significant predictor of overall survival in patients with renal cancer undergoing partial or radical nephrectomy, a new study published online ahead of print in the Journal of Urology has shown.1

Because data from non-surgical patients with chronic kidney disease (CKD) suggest proteinuria to be an independent predictor of renal function decline and mortality, researchers sought to evaluate whether preoperative proteinuria impacts survival in patients with kidney cancer undergoing nephrectomy.

For the study, researchers analyzed data for 900 patients with kidney cancer undergoing partial or radical nephrectomy. Patients were grouped according to glomerular filtration rate (GFR) level, proteinuria level, and CKD risk classification.

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Results showed that preoperative GFR, proteinuria, and CKD risk group were highly significant predictors of overall survival (P<0.0001). All were associated with poor overall survival.

“Classification according to preoperative GFR and proteinuria more accurately predicts survival [than] using GFR alone after accounting for cancer stage. This information supports the routine evaluation of proteinuria in kidney cancer patients,” the authors concluded.


  1. Tourojman M, Kimiz S, Boelkins B, et al. Impact of reduced GFR and proteinuria on overall survival of renal cancer patients [published online ahead of print on September 30, 2015]. J Urol. doi: 10.1016/j.uro.2015.09.083.