The cost of treatment for patients with RCC imposes its own burdens. A 2014 study of the lifetime costs associated with 2 of the oral therapies currently prescribed, everolimus and axitinib, estimated that monthly drug acquisition costs reached $9174 and $10,558 respectively.4

As the ASCO report, looking at cancer treatment in general, stated, “patients without health insurance are especially vulnerable to high drug costs, but costs can be unaffordable even for those with insurance when high deductibles transfer more of the cost of treatment to the insured. The result is that out-of-pocket drug expenses for patients with health insurance can run $25,000 or more per year.”

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Multiple studies have noted that the economic burden frequently leads to patients failing to adhere to treatment regimens.

“The price of many cancer drugs also forces patients and families to make difficult financial choices about whether to forego or curtail needed treatments,” according to the ASCO report. “Some estimates suggest that 10% to 20% of patients with cancer may not take prescribed treatments because of the cost and that they are more likely to declare bankruptcy than those without cancer.”

The result is a frustrating paradox for oncologists: even as a host of new and increasingly effective therapies are becoming available for a variety of cancers, patients are delaying or discontinuing use of those life-saving specialty drugs because of the financial burden, with a direct impact on overall survival.

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Chronic myeloid leukemia, for instance, is considered highly treatable, with lifespans of patients adhering strictly to a tyrosine kinase inhibitor regimen similar to someone without cancer.

But missing as few as 3 prescribed doses in a month is associated with significantly worse outcomes, according to the authors of a 2017 study that found a disturbingly high relationship between insurance status and overall survival.5

For patients under 65 years, the authors of that study wrote, “patients who were uninsured or had Medicaid insurance had an approximately 2-fold hazard for death in comparison with patients with other insurance.”

A 2015 analysis of treatment with imatinib concluded unequivocally that “poor adherence to imatinib therapy is the most important factor contributing to cytogenetic relapse and imatinib failure. It is therefore of paramount importance that physicians recognize this problem and work toward improving adherence in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.” 6

A year before that analysis, a study of chronic myeloid leukemia patients found that cost was one of the primary factors in targeted therapy nonadherence.7

“Approximately 17% of patients with higher copayments and 10% with lower copayments discontinued [tyrosine kinase inhibitors] during the first 180 days following initiation (adjusted risk ratio [aRR], 1.70; 95% CI, 1.30-2.22),” the study found. “Similarly, patients with higher copayments were 42% more likely to be nonadherent.”

Barriers to receiving treatment, including cost, should therefore be considered as important as the research leading to clinical improvements. The authors of the new mRCC study concluded that “advances have led to increased therapeutic options for many oncology patients, yet these treatments are only beneficial if individuals can access them.”

References

  1. Li P, Wong YN, Jahnke J, Pettit AR, Doshi JA. Association of high cost sharing and targeted therapy initiation among elderly Medicare patients with metastatic renal cell carcinoma. Cancer Med. 2017 Dec 1. doi: 10.1002/cam4.1262 [Epub ahead of print]
  2. American Society of Clinical Oncology. The state of cancer care in America, 2016: a report by the American Society of Clinical Oncology. J Oncol Pract. 2016;12(4):339-83. doi: 10.1200/JOP.2015.010462
  3. Tefferi A, Kantarjian H, Rajkumar SV, et al. In support of a patient-driven initiative and petition to lower the high price of cancer drugs. Mayo Clin Proc. 2015;90(8):996-1000. doi: 10.1016/j.mayocp.2015.06.001
  4. Perrin A, Sherman S, Pal S, et al. Lifetime cost of everolimus vs axitinib in patients with advanced renal cell carcinoma who failed prior sunitinib therapy in the US. J Med Econ. 2015;18(3):200-9. doi: 10.3111/13696998.2014.985789
  5. Perry AM, Brunner AM, Zou T, et al. Association between insurance status at diagnosis and overall survival in chronic myeloid leukemia: a population-based study. Cancer. 2017;123(13):2561-9. doi: 10.1002/cncr.30639
  6. Knopf KB, Divino V, McGarry L, et al. Economic burden of tyrosine kinase inhibitor treatment failure in chronic myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015;15(11):e163-71. doi: 10.1016/j.clml.2015.07.647
  7. Dusetzina SB, Winn AN, Abel GA, Huskamp HA, Keating NL. Cost sharing and adherence to tyrosine kinase inhibitors for patients with chronic myeloid leukemia. J Clin Oncol. 2014;32(4):306-11. doi: 10.1200/JCO.2013.52.9123

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Chronic Myeloid Leukemia Renal Cell Carcinoma Side-Effect Management