Renal cell carcinoma (RCC) incidence is on the rise in many countries, with widening mortality trends in less developed countries, according to a study published in European Urology.

Researchers led by Ariana Znaor, MD, PhD, of the International Agency for Research on Cancer in France looked at data from GLOBOCAN, the Cancer Incidence in Five Continents series, and the World Health Organization mortality database to map out incidence rates in more than 40 countries.

They used joinpoint analyses of age-standardized rates (ASRs) in order to measure trends in the last ten years.

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The study found that the incidence of RCC in men varied worldwide, with 1 in 100,000 in African countries to more than 15 in 100,000 in several European countries and among blacks in the U.S. 

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They saw similar patterns in women, but the incidence rates were more likely half of those found in men.

Incidence rates are rising in many countries, most notably in Latin America, and while mortality trends are stabilizing, there is a significant decline in Western and Northern Europe, the U.S., and Australia.

“Although some progress towards stabilization of mortality trends has been achieved globally, differences in mortality between areas of higher and lower human development levels persist,” the authors concluded.


  1. Znaor, Ariana, et al. “International Variations and Trends in Renal Cell Carcinoma Incidence and Mortality.” European Urology. DOI: 10.1016/j.eururo.2014.10.002. March 1, 2015.