Study May Lead to Discovery of New RCC Biomarkers

the Cancer Therapy Advisor take:

In a small study of five patients with renal cell carcinoma (RCC), researchers found expression patterns of long non-coding RNAs (lncRNAs) and aberrant lncRNAs and mRNAs in tumor samples versus non-tumor tissues. A microarray of lncRNA identified 27,279 lncRNAs in samples of RCC—480 of which were significantly upregulated and 417 of which were significantly downregulated, as compared with non-tumor tissue. Researchers also discovered 19,995 mRNAs—458 of which were significantly upregulated and 413 of which were significantly downregulated. They also noted a link between AK096725 and ENST00000453068 in 70 paired samples. This connection between RCC and AK096725 in particular may lead to the discovery of new biomarkers in RCC, according to the researchers.