Increased Risk of Cancers for Firefighters at WTC on 9/11
The firefighters had elevated standardized incidence ratios for prostate cancer and melanoma.
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Pretreatment Found to Reduce Stages of Mohs Surgery for Basal Cell Carcinoma
A retrospective study evaluated the effect of 5% imiquimod prior to Mohs surgery in patients with basal cell carcinoma.
Gut Bacteria Linked to Immunotherapy Response, Toxicity in Melanoma Patients
Bacteroides intestinalis and Intestinibacter bartlettii were significantly enriched in patients who experienced severe toxicity.
Tebentafusp Gets Priority Review for Metastatic Uveal Melanoma
The application is supported by data from the phase 2 IMCgp100-202 trial that assessed tebentafusp in 378 HLA-A*02:01-positive adults with previously untreated metastatic uveal melanoma.
Racial Disparities in Skin Cancer Diagnosis, Prognosis, and Treatment
How significant is the racial disparity in treating patients with skin cancer? Studies in recent years that suggest a troubling difference in the diagnosis and treatment some patients receive. We explore the significant impact this has on patient prognosis.
Previous Tx in Metastatic Melanoma May Cut Response to ACT TIL
Prior therapy linked to lower objective response rate to adoptive cell transfer with tumor-infiltrating lymphocytes compared with no prior therapy.
Dermatologic Adverse Events With Immune Checkpoint Inhibitors in Metastatic Melanoma
Female patients showed an enhanced rate of dermatologic adverse events with immune checkpoint inhibitor therapy for metastatic melanoma.
Cutaneous Beta-HPV May Up Risk for Cutaneous Squamous Cell Carcinoma
Beta-HPV detected in skin swabs may predict cuSCC risk, but no link seen for serologic evidence of past beta-HPV infection.
Fewer Cancers Might Be Missed With Full-Body Skin Examinations
Authors recommend that dermatologists perform a total-body skin examination even when a patient is referred for a suspicious lesion.
Real-World Data Show an Overall Decrease in Pediatric Melanoma Diagnoses in the United States
Researchers studied a total of 1903 cases of pediatric melanoma and patients were 54.4% female, the mean age was 12.4 years, and 89.8% were White.
Topical Remetinostat Reduces Disease Burden in Patients With Basal Cell Carcinoma
Remetinostat produced a complete response in 17 of 33 tumors.
Certain Dermoscopic Structures Linked to Melanoma Detection
Odds for melanoma detection highest for presence of white structures, pseudopods, irregular pigmentation, blue-white veil, and peppering.
Response Endpoints Deemed ‘Poor Surrogates’ for Overall Survival in Trials of Immune Checkpoint Inhibitors
Response endpoints were not strongly correlated with overall survival at the trial level.
Blood-Based Test May Establish a ‘New Paradigm’ for Cancer Screening
The test can accurately detect cancer and predict where it is located, according to researchers.
Ipilimumab Plus Nivolumab Improves Survival in Melanoma With Brain Metastases
Combination ipilimumab and nivolumab reduced the risk of death by 56% when compared with fotemustine monotherapy.
Cemiplimab Deemed Active, Safe After HHIs in Locally Advanced Basal Cell Carcinoma
Phase 2 trial results supported the approval of cemiplimab for this patient group.
Bempegaldesleukin Plus Nivolumab Elicits Responses in Treatment-Naïve, Advanced Melanoma
More than half of patients responded, and responses deepened over time.
Stopping Ipi/Nivo for irAEs Did Not Affect Advanced Melanoma Survival
Immune-related adverse events were associated with improved survival outcomes.
Two Doses of COVID-19 Vaccine Appear Necessary to Protect Cancer Patients on Active Treatment
Cancer patients had a low rate of seropositivity after the first vaccine dose but not after the second dose.
Keytruda Approved for Locally Advanced Cutaneous Squamous Cell Carcinoma
Results showed an overall response rate of 50%, with 17% of patients achieving complete response and 33% having partial response.
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