The incidence of bladder cancer is increasing, especially for women, according to an article published online ahead of print in JAMA Oncology.1

Researchers conducted a systematic review to profile occupational hazards by bladder cancer incidence and mortality risk over time.

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Meta-analysis showed an increased incidence in bladder cancer in 42 of 61 occupational classes and increased bladder cancer specific mortality in 17 of 40 occupational classes. Reduced incidence and mortality were observed in 6 of 61 and 2 of 40 classes, the authors noted. 

Risk varied with sex and was greater in men. From the 1960s to the 1980s, there was a steady decline in standardized incidence ratio for both sexes and the trend reversed itself in the 1980s. In 2000 to 2010, the standardized incidence ratio increased to 1.13 (95% CI: 1.07-1.19) for men and 1.27 (95% CI: 1.12-1.43) for women. However, mortality risk declined in both sexes from the 1960s to the 1990s.

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Limitations to the study included possible publication bias.

The authors concluded that the increase could be attributed to improved detection and screening methods.

Editor’s Note: The original version of this article incorrectly stated the number of bladder cancer specific mortality. JAMA Oncology has updated the information and it has been corrected in this article on November 11, 2015.


  1. Cumberbatch MGK, Cox A, Teare D, Catto JWF. Contemporary occupational carcinogen exposure and bladder cancer: a systematic review and meta-analysis. [published online ahead of print October 8, 2015]. JAMA Oncol. doi: 10.1001/jamaoncol.2015.3209.