How can I be sure that the patient has disease ?

*** Vomiting, diarrhea, anorexia. (What signs and symptoms are usually found?)

*** Type Here. (What is the usual constellation of clinical features?)

A tabular or chart listing of features and signs and symptoms

*** Type Here. (Are there pathognomonic or characteristic features?)

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*** Type Here. (What are some less common clinical presentations?)

*** Type Here. (What other diseases and conditions might mimic the signs, symptoms, or clinical features of disease X: A tabular chart listing these alternative diagnoses and the key features allowing this differentiation)

How can I confirm the diagnosis?

*** Type Here. (What tests should be ordered first?)

*** Type Here. (What tests should be used to confirm the initial tests?)

*** Type Here. (What tests are useful if the diagnosis is still in doubt?)

*** Type Here. (A diagnostic algorithm)

*** Type Here. (A tabular or chart listing of laboratory tests, radiographic studies, and endoscopic evaluations with descriptions of expected findings, consistent findings, and inconclusive results. Include in this advice as to the next step if additional testing would be necessary and if so, what should be ordered at that point.)

What other diseases, conditions, or complications should I look for in patients with disease X?

*** Type Here. (What are the major risk factors for patients with this disease?)

*** Type Here. (What diseases may occur with disease X?)

*** Type Here. (What complications of disease X are commonly encountered?)

*** Type Here. (A tabular or table list of these complications, including comments on magnitude of risk.)

What is the right therapy for the patient with disease X?

*** Type Here. (What treatment options are effective?)*** Type Here. (A listing of all options, lifestyle, medical endoscopic surgical, other estimates of efficacy )

What is the most effective initial therapy?

*** Type Here.

Listing of usual initial therapeutic options, including guidelines for use, along with expected result of therapy.

*** Type Here. (What therapy is best if initial therapy fails, including definitions of failure?)

A listing of a subset of second-line therapies, including guidelines for choosing and using these salvage therapies

*** Type Here. (What side-effects or complications should I expect from therapy?)

Listing of these, including any guidelines for monitoring side effects.

*** Type Here. (A therapeutic algorithm)

How should I monitor the patient with disease X?

*** Type Here. (How should I monitor complications of the disease?)

*** Type Here. (How should I monitor progress of stage of the disease?)

*** Type Here. (Listing of measures of progress of disease or monitoring recommendations, including timing and interpretation. Explanations of next step if this monitoring reveals an abnormality.)

What's the evidence?