All the Guidelines in the World Can’t Eliminate Gray Areas
Jim Anderson, MPAS, PA-C, explores the role and limits of guidelines.
Viewpoints
Viewpoints
Adagrasib Shows Promising Activity in Gastrointestinal Cancers
In the KRYSTAL-1 trial, adagrasib produced a 100% disease control rate in patients with gastrointestinal cancers.
Phase 3 Studies Herald More Options for Metastatic Breast Cancer
Dr Alan Lyss details the results and clinical implications of the EMERALD, PHOEBE, and DESTINY-Breast03 trials.
Genetic Differences May Partly Explain Racial/Ethnic Disparities in Early-Onset Colorectal Cancer
Data from the GENIE registry revealed distinct genomic patterns in patients of different races/ethnicities.
Equal Access to Care May Eliminate Racial Disparities in Lung Cancer Outcomes
One study suggested that modifiable factors could improve racial disparities in the stage at which lung cancer is diagnosed.
Adult Participation in Cancer Trials Higher Than Previously Thought
Enrollment rates varied widely by study type and institution.
First-Line Immunotherapy Continues to Best Chemo in Malignant Pleural Mesothelioma
Data suggest nivolumab plus ipilimumab provides a long-term survival benefit in patients with unresectable malignant pleural mesothelioma.
Changes in Clinical Trial Conduct Prompted by the COVID-19 Pandemic Should Persist
The AACR COVID-19 and Cancer Task Force recommends keeping changes to clinical trial practices that were prompted by the pandemic.
KRAS G12C Mutations in Metastatic Colorectal Cancer: Questions Remain
Dr Alan Lyss reviews studies of KRAS G12C mutations in metastatic colorectal cancer.
On-Treatment Ki-67: A Promising Prognostic Marker for Early Breast Cancer Management
Dr Alan Lyss reviews results from the high-risk cohort of the WSG-ADAPT HR+/HER2- trial.
On-Body Injections of Pegfilgrastim May Not Always Be Preferred — But They’re On Schedule
Preferences are tied not just to the experience of receiving an injection, but also to factors related to a patient’s access to different types of care settings.
American Cancer Society Updates Cervical Cancer Screening Guidelines
New guidelines from the American Cancer Society (ACS) appear to move away from the reliance on cytology screening via Pap testing.
Prostate Cancer Metastasizes by Hijacking a Developmental Epigenetic Program
Localized prostate cancer is thought to metastasize by tapping into a developmental program used by its embryonic ancestors.
Skin Toxicity Program Can Positively Address EGFR Inhibitor-Related Skin Toxicities
Patients given prophylactic treatment were 94% less likely to require a first rescue treatment for rash and 74% less likely to require a second rescue treatment.
Can Culturing CAR T Cells With Ibrutinib Improve Their Efficacy in CLL?
Sustained remission of CLL is associated with enrichment of a less-differentiated, early-memory phenotype of T cells in the apheresis product used to make CAR-T therapies.
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