Anti-CD137 Antibody ADG106 Appears Safe in Dose-Escalation Phase 1 Trial
ADG106 showed no concerning safety signals in the phase 1 trial, and a preliminary result in follicular lymphoma suggests possible clinical activity.
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FDA Grants Accelerated Approval to Brukinsa for Mantle Cell Lymphoma
Continued approval may be contingent upon verification of clinical benefit in a confirmatory trial.
Evidence Supports the Potential Use of KRAS(G12C) Inhibitor, Maybe Even in Combination
Preclinical and emerging clinical evidence support the possible use of AMG 510 as a single-agent KRAS (G12C) inhibitor, but preclinical evidence may also support the agent in combination.
Quality of Life With Busulfan and Fludarabine Compared With Busulfan and Cyclophosphamide
Patients with acute myeloid leukemia and myelodysplastic syndromes reported similar quality of life irrespective of the conditioning regimen the received.
Secondary Surgical Cytoreduction Not Superior in Ovarian Cancer
Addition of surgery prior to chemotherapy does not prolong overall survival in recurrent ovarian cancer.
Response-Adapted Intensification in Multiple Myeloma After Suboptimal Response to Induction
Patients who received intensification treatment experienced longer progression-free survival compared with patients receiving maintenance treatment.
Overall Survival Benefit With Durvalumab Continues at 3-Year Follow-Up
Patients with advanced non-small cell lung cancer who did not have disease progression after chemoradiotherapy appeared to have a long-term survival benefit with durvalumab.
High-Throughput Multichain Immune Repertoire Sequencing for Prediction of Treatment Response in Renal Cell Carcinoma
Next-generation sequencing is being increasingly used to characterize the diversity of T-cell and B-cell receptors in individuals.
Physical Activity After Cancer Diagnosis Improves Survival
Findings seen among postmenopausal breast cancer patients regardless of activity level prediagnosis.
Nurse Practitioner-Led Rapid Diagnosis Clinic May Reduce Time to Diagnosis in Lymphoma
Patients referred to the clinic were diagnosed nearly 2 weeks faster compared with historical controls.
Characteristics Identified for Checkpoint Inhibitor-Resistant Patients
Patients with NSCLC who did not respond to immune checkpoint blockade had unique molecular characteristics, revealing possible therapeutic targets.
ACAAI: Family History of Cancer Risk Factor for Childhood Asthma
More than 20 percent of those with family history of cancer had childhood asthma.
AHA: Cardiovascular Risk Factors Tied to Increased Cancer Risk
Risk for subsequent cancer up with development of interim CV events, including heart failure, MI.
MET Gene Amplification Found to Be Associated With Adverse Clinicopathological Features in Gallbladder Cancer
In this study, there was no correlation between the presence of MET gene amplification and the presence of MET protein overexpression.
Gastrointestinal Involvement May Be a Sign of Waldenström Macroglobulinemia
Gastrointestinal-tract involvement may be a comorbid condition in patients with Waldenström macroglobulinemia.
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