AACR 2019

Complete Coverage

An Investigation of the Plasma Metabolome in Patients With Small Cell Lung Cancer

Exposure of patients with small cell lung cancer to platinum-based chemotherapy resulted in altered levels of specific plasma lipids.

Limited Clinical Benefit for the Combination of TRC102 and Temozolomide in Refractory Colorectal Cancer

The median number of prior treatments for patients with relapsed colorectal cancer enrolled in this phase 2 study was 6.

Tumor Biopsy Found Less Effective Than Liquid Biopsy for Identifying Resistance Mechanisms in Some GI Cancers

In 78% of patients, circulating cell-free tumor DNA identified a possible mechanism of acquired resistance not identified by standard tumor DNA sequencing.

The Predictive Ability of a Cancer Subtype Ontology Assignment

The Cancer Subtype Ontology resource includes 840 different cancer subtypes, many of which are novel.

Investigating CD133 as a Biomarker of Prostate Cancer Disparity in African American Men

CD133 has often been used as a marker of cancer stem cells.

COLOMATE: Using a Liquid Biopsy in CRC to Select a Molecularly Targeted Therapy

The companion study arms under the COLOMATE trial umbrella will include those that specifically enroll patients with HER2-amplified or EGFR-mutant disease.

Two RNA Sequencing Inflammatory Scores as Predictors of Benefit From Pembrolizumab in Advanced Breast Cancer

The search for robust biomarkers in the tumor immune microenvironment that could be predictive of response to immune checkpoint blockade is ongoing.

FFPE Tissue Specimens Deemed Adequate for Molecular Studies: NCI-SEER

Regions of tumor and normal tissue on FFPE tissue specimens obtained from the NCI SEER-linked Virtual Tissue Repository were annotated by a pathologist.

Novel Toxicities, Anticancer Activity of Anti-CD22 CAR-T Therapies Revealed

Hemophagocytic lymphohistiocytosis is a rare, but potentially fatal, complication of immunotherapy, resulting from immune hyperactivation.

Colorectal Cancer Pathogenesis May Be Driven by Alterations in MACROD2

The appearance of structural variants in MACROD2, culled from sequencing data from patients with colorectal cancer, may be a hallmark of CRC pathogenesis.

Patient Diversity in Clinical Trials: Best Practices for Accrual

Populations studied in clinical research must mirror real-world patient demographics.

Combining CAR-T and BiTE in Models of Glioblastoma Multiforme

This study involved the engineering of CAR-T cells specific for the EGFRvIII antigen to also secrete bispecific T cell engagers (BiTEs) against wild-type EGFR.

NCI-MATCH: No Objective Responses to Palbociclib in Patients With CCND-Amplified Tumors

In the palbociclib/CCND-amplification arm of the NCI MATCH trial, 42% of patients had received more than 4 prior lines of therapy.

High Baseline Inflammatory Biomarker Levels Linked to Shorter OS in mTNBC

On multivariate analyses, high baseline levels of IL-6 and CRP, but not IL-8, were associated with shorter OS in patients with breast cancer receiving atezolizumab.

Immune Biomarkers as Predictors of Response to Checkpoint Blockade in Breast Cancer

Results from this study showed that a close spatial distribution between CD3-positive T cells and cancer cells was a biomarker for response to pembrolizumab.

Chemoimmunotherapy Confers Survival Benefit in Patients With HPV16-Induced Cervical Cancer

Coadministration of the HPV16-specific vaccine, ISA101, with chemotherapy was found to be associated with stronger tumor immunity.

BiTE Antibody Constructs and Treatment-Resistant Metastatic Melanoma

Researchers suggest using novel therapies that act by a distinct mechanism of action to boost durable response rates in patients with treatment-resistant metastatic melanoma.

High Circulating Levels of Cytomegalovirus DNA Linked to Poor OS in Head and Neck Cancer

Evidence is provided for an association between CMV reactivation and poor OS of patients with head and neck cancer in the setting of high systemic inflammation.

Delivery of Alternating Electrical Fields Increases Cell Membrane Permeability in Glioblastoma Multiforme

The researchers speculated that the delivery of alternating electric fields to GBM cells may facilitate the delivery of chemotherapy.

An Integrated Analysis for Selecting Ibrutinib-Based Combination Therapy in CLL

An integrated assessment of the results from 2 assays showed promise for tailoring ibrutinib-based targeted therapy in patients with CLL.