Neoadjuvant Chemo Appears No Better Than Upfront Surgery for Colon Cancer
Neoadjuvant chemotherapy does not improve survival outcomes vs upfront surgery in patients with locally advanced colon cancer, a phase 3 trial suggests.
American Society of Clinical Oncology (ASCO)
Perioperative Toripalimab and Chemo Deemed Potential Standard Care in Stage III NSCLC
Perioperative toripalimab plus chemotherapy improves event-free survival over chemotherapy alone in stage III non-small cell lung cancer, a phase 3 study suggests.
First-Line Pembrolizumab Improves Survival in Metastatic Cervical Cancer
Updated data support the use of pembrolizumab in combination with chemotherapy as first-line standard care for patients with persistent, recurrent, or metastatic cervical cancer.
Adding Talazoparib to Enzalutamide Appears Beneficial in mCRPC With HRR Mutations
Adding talazoparib to first-line treatment with enzalutamide improves rPFS in patients with HRR-deficient mCRPC, a phase 3 trial suggests.
Many Patients With Locally Advanced Rectal Cancer Can Forgo Pelvic Radiation
In the phase 3 PROSPECT trial, patients with locally advanced rectal cancer had similar outcomes if they received pelvic chemoradiation or if they received FOLFOX with chemoradiation added only in select cases.
Adjuvant Osimertinib Improves OS in EGFR-Mutant, Early-Stage NSCLC
The ADAURA trial is the first global phase 3 study to show an overall survival benefit with targeted treatment in resected, EGFR-mutated, stage IB-IIIA non-small-cell lung cancer, according to study presenter Roy S. Herbst, MD, PhD.
Vorasidenib May Be New Standard Care for IDH1/2-Mutated Glioma
If approved, vorasidenib could become a new standard of care for low-grade IDH1/2-mutated gliomas, according to an ASCO discussant.
Zanidatamab Yields Durable Responses in HER2+ Biliary Tract Cancer
Zanidatamab can produce rapid and durable responses in patients with advanced HER2-positive biliary tract cancer, phase 2 data suggest.
Adding Dostarlimab to Chemotherapy Improves PFS in Endometrial Cancer
Adding dostarlimab to treatment with carboplatin and paclitaxel improves progression-free survival in advanced or recurrent endometrial cancer, the phase 3 RUBY trial suggests.
Neoadjuvant Nivolumab Plus Relatlimab Appears Safe and Effective in NSCLC
Curative surgery for non-small cell lung cancer after treatment with nivolumab plus relatlimab is as safe as surgery after nivolumab alone, the NEOpredict-Lung study suggests.
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