The following article features coverage from the ASCO Gastrointestinal Cancers Symposium 2021 meeting. Click here to read more of Cancer Therapy Advisor‘s conference coverage.

Results from a long-term survival analysis of the ATTRACTION-1 study demonstrated nivolumab’s enduring efficacy in patients with advanced esophageal squamous cell carcinoma (ESCC), according to data based on a minimum of 5 years of follow-up presented at the 2021 Gastrointestinal Cancers Symposium.

A total of 65 patients with advanced ESCC who were either refractory to or could not tolerate fluoropyrimidine-, platinum-, and taxane-based therapy enrolled on the phase 2 ATTRACTION-1 trial between February 25, 2014 and November 14, 2014, and 64 were evaluated for treatment efficacy. At the final database lock for long-term follow-up analysis on August 6, 2020, 17.2% of patients were found to have an objective response by central assessment (95% CI, 9.9-28.2), reported Ken Kato, MD, PhD, of National Cancer Center Hospital in Japan.

The median overall survival (OS) was 10.8 months (95% CI, 7.4-13.9), and the estimated 5-year OS rate was 6.3% (95% CI, 2.0-14.0). The median progression-free survival (PFS) wasn1.5 months (95% CI, 1.4-2.8). The estimated 5-year PFS rate was 6.8% (95% CI, 2.2-15.1). These findings represent the longest follow-up of patients with advanced ESCC treated with nivolumab, according to Kato, who added that “long-term survivors tended to show [a] deeper response.”

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Importantly, no new safety signals were identified during the longer follow-up period. The most common treatment-related adverse events (frequency of >10%) were diarrhea and rash.

The findings, which are consistent with those for nivolumab in other disease settings, build on 2-year follow-up data from ATTRACTION-1, which previously demonstrated nivolumab’s capacity to induce antitumor activity with a manageable safety profile.

Disclosures: Some of the study authors disclosed financial relationships with the pharmaceutical industry and/or the medical device industry. For a full list of disclosures, please refer to the original study. This clinical trial was supported by Ono Pharmaceutical and Bristol-Myers Squibb.

Read more of Cancer Therapy Advisor‘s coverage of the ASCO GI 2021 meeting by visiting the conference page.


Kato K, Doki Y, Ura T, et al. Nivolumab in advanced esophageal squamous cell carcinoma (ATTRACTION-1/ONO-4538-07): minimum of five-year follow-up. Poster presented at Gastrointestinal Cancer Symposium; January 15-17, 2021. Abstract 207.