Idelalisib + Bendamustine, Rituximab: Important New Option for Relapsed/Refractory CLL
Idelalisib in combination with bendamustine and rituximab is superior to bendamustine and rituximab alone.
Idelalisib in combination with bendamustine and rituximab is superior to bendamustine and rituximab alone.
In “ultra-high risk” patients with chronic lymphocytic leukemia (CLL), treatment with venetoclax monotherapy resulted in a high overall response rate.
Results of a phase 3 randomized trial support high intensity conditioning prior to allogeneic stem cell transplantation as standard of care.
The first clinical trial of an anti-B-cell maturation antigen chimeric antigen receptor (CAR-BCMA) has shown strong anti-myeloma activity.
Minimal residual response (MRD) induced by blinatumomab montherapy was associated with longer survival and duration of response.
Adding ixazomib to lenalidomide plus dexamethasone in patients with relapsed/refractory multiple myeloma increased progression-free survival.
Ibrutinib is superior to temsirolimus for progression-free survival in patients with relapsed/refractory mantle cell lymphoma (MCL).
Combination of brentuximab vedotin with bendamustin is effective in Hodgkin lymphoma and anaplastic large T-cell lymphoma (ALCL).
Obinutuzumab monotherapy for 1 cycle followed by venetoclax and obinutuzumab in elderly patients with chronic lymphocytic leukemia (CLL).
brutinib monotherapy was superior to chlorambucil with regard to survival and hematologic improvement.