A Glimpse of ASH
Dr Isabel Cunningham discusses some of the important studies presented at the 2016 ASH meeting.
ASH 2016
Idarubicin + HDAC ± Vorinostat Not Superior to 7+3 in AML
Idarubicin plus high-dose cytarabine (HDAC) with or without vorinostat was not superior to 7+3 chemotherapy.
Nilotinib Discontinuation Following Deep Molecular Response
Some patients with chronic myeloid leukemia (CML) who have maintained deep molecular responses for at least 2 years can safely discontinue nilotinib.
TKI Cessation Appears Feasible, Safe in Patients With CML
Tyrosine kinase inhibitor (TKI) cessation appears feasible and safe in patients with chronic myeloid leukemia in chronic phase (CML-CP).
No Impact of Detectable Disease on MRFS After Imatinib Cessation in CML
There were no differences in molecular relapse-free survival between patients with prior 4.5 log reduction but detectable disease and those with undetectable disease
CML-CP: Second TKI Discontinuation Safe and Successful
Tyrosine kinase inhibitors (TKIs) can be safely and successfully discontinued a second time despite failing first discontinuation.
ATRA + Arsenic Trioxide Active in Acute Promyelocytic Leukemia
All-trans retinoic acid (ATRA) plus arsenic trioxide with or without chemotherapy induces high remission rates.
Imatinib Generics Appear Non-inferior to Gleevec Brand Formulation in CML-CP
Generic formulations of imatinib appear to be non-inferior to Novartis’s Gleevec brand formulation with respect to clinical efficacy and tolerability.
Lower Intensity Intensification Therapy in Childhood ALL
Pediatric patients with acute lymphoblastic lymphoma (ALL) at standard risk for relapse do not benefit from lower-intensity, delayed intensification therapy.
Serum Free Light Chain Responses Better for Predicting Clinical Outcomes
Serum free light chain measurements correlate more closely with clinical outcomes than urine assessments in patients with light chain multiple myeloma.
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