The following article features coverage from the American Society of Hematology (ASH) 2018 meeting. Click here to read more of Cancer Therapy Advisor‘s conference coverage.

More data on an anti-B-cell maturation antigen chimeric antigen receptor T-cell therapy (anti-BCMA CAR-T) was released at the 2018 American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, California.1

This particular antimyeloma cellular therapy, LCAR-B38M, is a little different than some of the other BCMA CAR-T therapies in that it actually targets 2 separate BCMA epitopes (2 binding domains) at once.

Although the researchers listed 74 total participants in the trial, all of the data are not new — some of them were first presented at 3 prior cancer meetings.  And, some of the slides reported statistics out of a sample size of 74, while other slides included 57 patients, which was the number of patients seen at the Xi’an site in China as of June 25, 2018.

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In the current study, overall response rate was 88%, with a complete response of 34%. The duration of response was 22 months. Forty-two patients (74%) saw a minimal residual disease (MRD)-negative complete response (CR). Twelve-month progression-free survival was 61%, while 12-month overall survival was 75%. There were 17 deaths, 14 of which were due to progressive disease.

The key objectives of the study were to test the safety of LCAR-B38M CAR-T cells and gauge their antimyeloma activity based on IMWG criteria.

Patients had a median of 3 prior lines of therapy (range, 1-9); of these prior medications, the largest proportion of patients had received a prior immunomodulatory imide (86%).

At least 20% of all patients saw adverse events; 90% of patients experienced cytokine release syndrome (CRS) of any grade, and 91% of patients had pyrexia of any grade. Other adverse effects included thrombocytopenia, leukopenia, increased AST, anemia, hypotension, and neurotoxicity. One patient died as a result of PE/ACS before resolution of grade 2 CRS.

The researchers concluded that the MRD-negative CRs were durable, and responses were achieved with low CAR-positive T-cell doses. They determined BCMA expression did not correlate with clinical response. “A phase 1b/2 study with JNJ-68284528 is ongoing in the US (ClinicalTrials.gov Identifier: NCT03548207) and a phase 2 study will be initiated in China (CTR20181007) in 2019.”

Read more of Cancer Therapy Advisor‘s coverage of the ASH 2018 meeting by visiting the conference page.

Reference

  1. Zhao W-H, Liu J, Wang B-Y, et al. Updated analysis of a phase 1, open-label study of LCAR-B38M, a chimeric antigen receptor T cell therapy directed against B-Cell maturation antigen, in patients with relapsed/refractory multiple myeloma. Oral presentation at: American Society of Hematology 60th Annual Meeting & Exposition; December 1-4, 2018; San Diego, California. Abstract 955.