Researchers sought to determine if practicing Kegel exercises, a common pelvic-floor exercise, could prevent urinary and fecal incontinence in patients with prostate cancer.
This study provided evidence suggesting that advanced NSCLC characterized by a genomic alterations in both STK11 and KRAS may not respond well to immunotherapy.
In TAILORx, 84% of patients with a high recurrence score were treated with chemotherapy containing a taxane and/or an anthracycline prior to endocrine therapy.
While pembrolizumab was not superior to chemotherapy, survival times were similar, suggesting immunotherapy might offer an alternative to chemotherapy.
One finding was a drop in concordance rate for clonal alterations when NGS was performed on tumor tissue and ctDNA samples collected following treatment initiation.
Interestingly, concordance for estimates of TMB between NGS panels was higher for tumor specimens with a low compared with a high PD-L1 expression level.
Pembrolizumab monotherapy does not improve overall survival (OS) compared with single-agent chemotherapy among women with metastatic triple negative breast cancer (mTNBC).