IMDC Model Predicts OS After Second-line Targeted Therapy for mRCC
The International Metastatic Renal Cell Carcinoma Database Consortium model is predictive of patient survival after targeted therapy for mRCC.
Genitourinary Cancers Symposium 2014
Inherited MET Oncogene Variant Prognostic for Survival, Time to Recurrence in Clear Cell RCC
Patients with clear cell RCC and the inherited exonic MET rs11762213 had a worse clinical outcome.
Ipilimumab + RT Increases Median OS in Certain Patients with mCRPC
Ipilimumab plus RT vs. RT alone increased median OS in patients with chemotherapy-naïve mCRPC and specific prognostic features.
Trimodal Therapy Effective in Invasive Bladder Urothelial Carcinoma Not Suitable for Cystectomy
Trimodal therapy is “appropriate” after transurethral surgery in muscle-invasive bladder urothelial carcinoma not suitable for cystectomy.
Radium-223: Long-term Follow-up Shows ‘No Major Safety Issues’
Radium-223 dichloride remains an “effective and well-tolerated” treatment for men with CRPC and bone metastases.
IMPACT Study Supports Targeted PSA Screening Based on BRCA1/2 Mutations
Preliminary results from the IMPACT study support the use of targeted PSA screening based on BRCA genotype.
Flavopiridol + FOLFOX ‘Active’ Against Some Late-relapse Germ Cell Tumors
Adding flavopiridol to FOLFOX combination chemotherapy appears to yield tumor responses in some late-relapse refractory germ cell tumors.
Partial, Complete Responses to Bladder-preserving Therapy Yield Similar Outcomes
Partial and complete responders to bladder-preserving induction chemotherapy for bladder cancer have similar long-term outcomes.
Little Evidence of OS Benefit for Orteronel + Prednisone in mCRPC
Adding orteronel to prednisone did not improve overall survival in men with metastatic castration-resistant prostate cancer.
Shorter ADT Linked to Fewer Quality-of-Life Impacts
Shorter-duration androgen deprivation therapy following radiotherapy is associated with better quality-of-life outcomes in high-risk prostate cancer.
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