Pretreatment ctDNA Predicts Survival in Non-Small Cell Lung Cancer
PD-L1 expression and tumor mutational burden were not associated with survival.
PD-L1 expression and tumor mutational burden were not associated with survival.
Enrollment declined 43% from 2019 to 2020.
Factors associated with poor survival were advanced age and male sex.
The 12-month progression-free survival rate was superior in the lurbinectedin arm.
The combinations conferred benefits in nonsquamous non-small cell lung cancer only.
The time from cytohistological diagnosis to treatment initiation was longer in 2019 than in 2020.
Researchers are evaluating whether specific anticancer therapies affect antibody levels.
Perioperative COVID-19 was associated with a 30-day mortality rate of 26%.
KEYNOTE-024 shows first-line pembrolizumab has long-term overall survival benefit in patients with advanced non-small cell lung cancer and PD-L1–expressing disease.
Although historically, the 5-year OS rate for patients with advanced NSCLC treated with chemotherapy is less than 5%, patients treated with nivolumab had a 5-year OS of 13.4%.