Upfront Radiotherapy May Benefit Medulloblastoma Patients With Li-Fraumeni Syndrome
Patients with sonic hedgehog medulloblastoma and Li-Fraumeni syndrome have a “dismal” prognosis, according to researchers.
ISPNO 2022
Reinduction Regimen Appears Effective in Children With Relapsed Medulloblastoma
The overall response rate after 2 treatment cycles was 78%.
RNA Sequencing Reveals Clinically Relevant Alterations in Pediatric Low-Grade Glioma
RNA sequencing confirmed the alterations most frequently described in low-grade glioma and revealed rare gene fusions.
Molecular Analysis Refines Diagnosis, Enables Personalized Treatment for Pediatric CNS Tumors
Of the patients who completed follow-up, 60% had a targeted therapy recommendation.
Larotrectinib Produces “Remarkable” Responses in NTRK Fusion-Positive CNS Tumors
The median duration of response was not reached at a median follow-up of 26 months.
Whole Ventricular Radiotherapy Alone Can Maintain CR in Patients With Localized Germinoma
Of the 65 patients who achieved a complete remission with chemotherapy, 63 remained in remission after whole ventricular radiotherapy and at the final follow-up.
Temozolomide Radiochemotherapy May Provide Benefit in High-Grade Glioma
The treatment proved noninferior to cisplatin-based radiochemotherapy.
Proton Therapy vs IMRT: Similar Risk of Secondary Neoplasms in CNS Tumor Survivors
There was no significant difference in rates of secondary neoplasms at 10 years.
Researchers Characterize Treatment Failure in CNS Non-Germinomatous Germ Cell Tumors
Metastatic relapse was associated with elevated tumor markers, but it was not associated with focal or whole ventricular radiotherapy.
Black Patients With Medulloblastoma Have Higher Risk of Death
Hispanic and non-Hispanic patients had a similar risk of death.
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