Radioactive seed localization (RSL) may be preferable to wire guided localization (WGL) for the resection of non-palpable invasive breast cancer and ductal carcinoma in situ, according to an article scheduled to be presented at the 2016 San Antonio Breast Cancer Symposium in Texas.1

WGL is the current standard for locating non-palpable breast lesions, though this method can result in positive margins post-resection. For this study, researchers evaluated whether RSL is superior to WGL for margins post-resection, duration of procedure, specimen weight, and patient pain.

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Of 413 cases of 409 patients enrolled to this randomized trial, 390 were included in the analysis; roughly half were assigned to either method.

Although no significant differences were found between positive margins after RSL or WGL, patient pain, or duration of the surgical procedure, a lower proportion of patients in the RSL group needed additional localization compared to the WGL group (2.1% vs 9.7%).

With RSL, furthermore, seed localization can be performed several days prior to the procedure.

RSL may therefore be preferable for resection in this patient population, according to the study’s authors.


  1. Langhans L, Tvedskov TF, Klausen TL, et al. Radioactive seed localization versus wire guided localization of nonpalpable invasive and in situ breast cancer: a Danish multicenter randomized controlled trial. Paper to be presented at: 2016 San Antonio Breast Cancer Symposium (SABCS); December 6-10, 2016; San Antonio, TX.