SGO 2020

Postsurgical Mutations Detected in Cell-Free DNA in Endometrial Cancer May Indicate Poor Prognosis

In this study, pre- and postsurgical specimens of cell-free DNA from women with newly diagnosed endometrial cancer were subjected to ultra-high depth sequencing.

Potential Predictors of Cell Transformation in Normal Fallopian Tubes of Women With a Deleterious BRCA1 Mutation

The search for molecular precursors of cancer in the fallopian tubes is largely driven by emerging evidence supporting it as the site of origin for many ovarian cancers.

Real-World Data Show Low Rates of Somatic BRCA Mutation Testing in Ovarian Cancer

This study evaluated the rates of germline and somatic BRCA testing in women with ovarian cancer included in the Flatiron Health database.

Learning Curve Associated With Minimally Invasive Radical Hysterectomy May Be Steep, Study Finds

Data used in this study were accessed from the National Inpatient Sample, which is sponsored by the Agency for Healthcare Research and Quality.

Further Refining Which Subgroups of Patients With Ovarian Cancer Benefit Most From Addition of Olaparib to Maintenance Therapy With Bevacizumab

PAOLA-1/ENGOT-ov25 is a phase 3 clinical trial evaluating a first-line olaparib plus bevacizumab maintenance regimen in patients with advanced ovarian cancer.

More Evidence Supporting the Clinical Benefit of Niraparib Maintenance Therapy After Chemo in Advanced Ovarian Cancer

This analysis presents preliminary data for secondary endpoints of TFST and PFS2 from the phase 3 PRIMA/ENGOTOV26/GOG-3012 study.

Phase 3 Trial Examining ICIs in Epithelial Ovarian Cancers Halted Due to Futility

JAVELIN Ovarian 100 was the first phase 3 study to evaluate an immune checkpoint inhibitor in previously untreated advanced epithelial ovarian cancer.

Study Findings Support the Use of Video-Assisted Genetic Counseling in Ovarian Cancer

NCCN Ovarian Cancer Guidelines include a recommendation for somatic and genetic testing following a genetic risk evaluation for all women with the disease.

Tumor Profiling Reveals Differences in Molecular Characteristics of Uterine Cancers in African-American and White Patients

In the United States, the mortality rate associated with uterine cancer is approximately twice as high for black women compared with white women.

Improved OS for Patients With HER2-Positive Uterine Serous Carcinoma Receiving Trastuzumab Plus Chemotherapy

It has been estimated that approximately 30% of patients with advanced uterine serous carcinoma have HER2-positive disease.

No OS Benefit for Addition of Metformin to Platinum-Based Therapy in Advanced Endometrial Cancer

The insulin-lowering properties of metformin, along with its effects on synthetic metabolism, were some of the rationales for its use as a cancer therapy.

Further Support for Sentinel Lymph Node Biopsy in Early-Stage Vulvar Cancer

This analysis represents the largest reported series of patients with early-stage vulvar cancer characterized by a negative sentinel lymph node biopsy.