Phase 3 Studies Herald More Options for Metastatic Breast Cancer
Dr Alan Lyss details the results and clinical implications of the EMERALD, PHOEBE, and DESTINY-Breast03 trials.
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No Benefit Seen With Longer Antibiotic Course After Surgery for Bone Tumors
There were no significant differences between the treatment groups in rates of surgical site infections, unplanned operations, oncologic events, or all-cause mortality.
Upfront Abiraterone for mCRPC Tied to Better Survival in Black vs White Men
In a study of men receiving first-line abiraterone for metastatic castration-resistant prostate cancer, Black men had a lower risk for death compared with White men.
Incidence of Advanced Lung Cancer Continues to Decline in the U.S.
Researchers projected that 1,918,030 new cancer cases and 609,360 cancer deaths will occur in the United States in 2022, including about 350 deaths per day from lung cancer.
Inotuzumab Ozogamicin Deemed Effective in Heavily Pretreated B-ALL
The estimated event-free survival rate was 28.6% at 2 years and 19.6% at 3 years.
Severe COVID-19 Outcomes Rare After Primary Vaccination
Severe COVID-19 outcomes were observed in 1.5 per 10,000 vaccinated people.
Use of Certain Prescription Meds Linked to COVID-19 Mortality
Discontinuation of an angiotensin-converting enzyme inhibitor, an angiotensin receptor blocker, or metformin was associated with an elevated risk of death among hospitalized COVID-19 patients.
Giving Immune Checkpoint Inhibitors Within 90 Days of Radiation Appears Safe
Rates of adverse events were generally similar between patients who did and did not receive radiation.
T-Cell Responses to COVID-19 Vaccines May Benefit Anti-CD20-Treated Lymphoma Patients
Despite an inferior rate of seroconversion, lymphoma patients treated with anti-CD20 therapy did mount T-cell responses.
Corticosteroids May Reduce Benefit From Enzalutamide in Prostate Cancer
Patients taking corticosteroids at baseline had significantly worse outcomes.
Young Adults With Cancer Facing Psychological Distress During Pandemic
High psychological distress was tied to lower quality of life, social isolation, and impaired cancer care.
Nearly 600,000 U.S. Children Had COVID-19 Last Week
Since the start of the pandemic, nearly 8.5 million US children have tested positive for COVID-19.
Pfizer Says Omicron-Specific Vaccine Ready by March
Both Pfizer and Moderna are developing omicron-specific COVID-19 vaccines.
U.S. Insurers Must Cover Eight COVID-19 At-Home Tests a Month: White House
Under the plan, people who provide insurance information at certain pharmacies will be able to get the tests with no out-of-pocket costs.
Metabolomic Analysis Can Detect Cancer Before Conventional Imaging
The method identified solid tumors in patients with nonspecific symptoms.
Hyperprogression After PD-1 Blockade Observed in Sarcoma Patients
The rate of hyperprogressive disease was 11%.
Psychological Distress More Likely in Young Adult Cancer Survivors
Roughly 11% of AYA cancer survivors reported psychological distress 20 years or more after their cancer diagnosis.
Tisagenlecleucel Deemed Effective in Relapsed/Refractory Follicular Lymphoma
The overall response rate was 86.2%, and the complete response rate was 69.1%.
5-Gene Risk Score Model Effectively Predicts Prognosis in Multiple Myeloma
Researchers sought to develop and validate a risk score model to predict prognosis for patients with multiple myeloma.
Red Cross Says U.S. Blood Supply at Dangerously Low Level
People who have received COVID-19 vaccines can donate blood and platelets as long as they are symptom-free.
U.S. COVID-19 Hospitalizations Pass Last Winter’s Peak
The surge in cases has overwhelmed hospitals nationwide, and about one-quarter face critical staffing shortages.
McKnight’s Newsmakers Podcast: Get Involved to Help Lonely Seniors, Doctor Advises
Diane Eastabrook provides a compelling series of articles describing how loneliness and isolation are affecting seniors living at home.
Oral Contraceptives
Progestin and estrogen content of oral contraceptives (birth control pills) chart.
Aesthetic Treatments for Post-Cancer Care
Cancer treatments may negatively affect the skin in a variety of ways, but aesthetic treatments can improve the skin’s appearance and patients’ quality of life.
Tucatinib Provides Lasting Survival Benefit in HER2+ Metastatic Breast Cancer
The 2-year overall survival rate was 51% in the tucatinib arm and 40% in the placebo arm.
Chemotherapy ‘Has Limited Role’ After ICI Failure in Metastatic Melanoma
The objective response rate was 12.5%, and the median progression-free survival was 2.6 months.
SD-101 Plus Pembrolizumab Elicits Responses in Head and Neck Cancer
Responses were seen in injected and non-injected lesions.
Younger Patients Who Survive Non-Hodgkin Lymphoma Face Higher Risk of Comorbidities
Researchers sought to determine the risk of comorbidities in younger patients who survive NHL compared with older patients.
BNT162b2 Still Effective, but Less So, Against Omicron
The effectiveness of 2 doses of the Pfizer-BioNTech COVID-19 vaccine was reduced during an omicron variant proxy period in South Africa.
Serious Adverse Effects From COVID-19 Vaccines Reported Rarely
Full vaccination dose, younger age, female sex, and previously having had COVID-19 were associated with greater odds of adverse effects.
EmblemHealth Develops Programs Around Senior Isolation
Diane Eastabrook provides a compelling series of articles describing how loneliness and isolation are affecting seniors living at home.
Black Prostate Cancer Patients Fare Better With RT, Despite More Aggressive Disease
Black race was associated with lower rates of biochemical relapse, distant metastases, and prostate cancer-specific mortality.
NGS-Guided Therapy Did Not Improve Outcomes in Triple-Negative Breast Cancer
There were no significant differences in outcomes between patients who received physician’s choice of therapy and those who received genomically directed therapy.
Camrelizumab Improves PFS, OS in Non-Small Cell Lung Cancer
Adding camrelizumab to chemotherapy reduced the risk of death by 45%.
Recurrence of Papillary Thyroid Cancer Predicted by Genetic Risk Model
Analysis of messenger RNA, microRNA, and protein-encoding genes may predict the risk of papillary thyroid cancer recurrence.
Stage Shift Tied to Decreased Population Mortality in NSCLC
A diagnostic shift from later-stage to earlier-stage disease may have implications for the evaluation of treatments and mortality outcomes.
Hospitals Are Rationing COVID-19 Pills, Infusions as Cases Rise
Doctors and health systems are rationing supplies to meet the needs of those in the most dire situations.
FDA Shortens Time to Booster After Moderna Vaccine to Five Months
A similar time window for boosters is already in place for people who received the Pfizer/BioNTech vaccine.
How Devices Can Provide Emotional Support and Engagement to Isolated Seniors
Diane Eastabrook provides a compelling series of articles describing how loneliness and isolation are affecting seniors living at home.
Risk Factors for Overactive Bladder and Urinary Incontinence
Risk factors for overactive bladder and urinary incontinence chart in men and women.
Erectile Dysfunction Treatments
Erectile dysfunction treatment chart including onset time, duration of action, and dosing for each drug product.
Urinary Incontinence
Types of urinary incontinence and its potential causes.
Chronic Obstructive Pulmonary Disease Treatments
List of FDA-approved medications used for the maintenance and treatment of chronic obstructive pulmonary disease (COPD).
Opioid Equianalgesic Doses
Opioid equianalgesic dosing chart used for interchanging between drug, route of administration, or both.
Neuropathic Pain Treatments
Chart with medications used to treat neuropathic pain, including diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia.
Narcotic Analgesics
A comparative chart of narcotic analgesics including formulations, strengths, and dosing intervals.
Migraine and Headache Treatments
Adult doses for migraine and headache treatments including barbiturates, ergot alkaloids, and NSAIDs.
Vaginal Infection Treatments
Oral and topical vaginal infection treatment options for vulvovaginal candidiasis and bacterial vaginosis.
Hormone Replacement Therapies
Chart with different formulations and combination of drugs used to treat menopause.
Hypertension Treatments: Oral CCBs
Oral calcium channel blockers (CCBs) for the treatment of hypertension including benzothiazepines, dihydropyridines, and diphenylalkylamines.
Gout Treatments
Gout treatment chart for acute attacks or chronic management/prevention.
COVID-19 and Lung Cancer: What We Know and Don’t Know
Researchers have summarized what is known about COVID-19 in the context of lung cancer and highlighted areas where more research is needed.
Roughly 1 in 5 Patients Had False-Positive Results of Breast Cancer Screening Over 20 Years
About 1 in 20 patients had an invasive procedure due to a false-positive result.
Relatlimab-Nivolumab Ups PFS in Untreated Advanced Melanoma
The median progression-free survival was 10.1 months with relatlimab-nivolumab and 4.6 months with nivolumab.
Metformin Use Linked to Prostate Cancer Risk
In a large study of men with newly diagnosed diabetes, exposure to metformin in the previous year was associated with an increased risk for a prostate cancer diagnosis, whereas exposure 2 to 7 years previously was associated with decreased risk.
Platelet, Hemoglobin Levels Related to COVID-19 Mortality in Hematologic Malignancies
A study suggests low platelet or low hemoglobin levels may be factors linked to COVID-19 mortality in patients with hematologic malignancies.
Tailored Strategies Can Up Depression Referrals in Breast Cancer
Referrals were made for 7.9% of patients in the tailored screening program and 0.1% of control patients.
Some At-Home Tests May Miss Omicron in Early Stages of Infection
The study included 30 people infected with SARS-CoV-2 at 5 workplaces that experienced likely outbreaks of the omicron variant last month.
Arthritis Treatments: NSAIDs
NSAIDS (non-steroidal anti-inflammatory drugs) indicated for the treatment of different types of arthritis.
Arthritis Treatments: DMARDS and Other Immune Modulators
A comparative list of treatment options for arthritis including DMARDS and other immune modulators.
Oral Urinary Tract Infection Treatments
Oral antibiotics for urinary tract infections (UTIs) treatment chart including dosing and duration.
Hepatitis B Virus Treatments
Hepatitis B Usual Dosing Chart
Hepatitis C Virus Treatment Guidelines
Evidence-based treatment guidelines for HCV infection from the expert panel of the AASLD and IDSA.
Antiretroviral Treatments
A list of treatment options for HIV infection.
Antibiotic Formulations
Antibiotic formulation (tablets, capsules, liquids, inhalations or injection) chart.
Anaphylaxis Management
Anaphylaxis management for outpatients, inpatients, and patients at discharge.
Irritable Bowel Syndrome Treatments
Drug therapy for the treatment of irritable bowel syndrome (IBS).
GERD Diagnosis and Management Guidelines
Expert recommendations for the diagnosis and management of gastroesophageal reflux disease (GERD).
Irritable Bowel Syndrome Evaluation
Irritable Bowel Syndrome (IBS) evaluation chart based on Manning Criteria and Rome III Diagnostic Criteria.
Bowel Cleansers
Bowel cleansing products comparison chart (hyperosmotics, isosmotics, isosmotic/stimulant laxative combinations, osmotics) used for colonoscopy preparation.
Tips for Caregivers to Identify Loneliness
Diane Eastabrook provides a compelling series of articles describing how loneliness and isolation are affecting seniors living at home.
Antiemetic Treatments
Antiemetic treatment chart including drug formulations, strengths, and usual doses for nausea/vomiting.
Glaucoma Treatments
Glaucoma treatment chart (alpha2-agonists, beta blockers, carbonic anhydrase inhibitors, cholinergic agonists, prostaglandin analogs).
Allergic Conjunctivitis Treatments
A comparative dosing chart of prescription and over-the-counter (OTC) medications for allergic conjunctivitis treatment.
Insulins
Types of insulins categorized by their pharmacodynamic properties.
Insulin Pen Devices
Insulin Pen Devices comparison chart for patients with diabetes mellitus.
Androgens
Androgens used for testosterone replacement therapy organized by route of administration chart.
Insulin Administration
Insulin preparations categorized by rapid-, short-, intermediate- and long-acting. Information such as the route, administration as well as the mixing of insulins is provided.
Acute Otitis Media Treatments
Acute otitis media treatment chart including select antibiotics and recommended doses.
Wound Care Products
Wound care dressings and cleansers including hydrocolloid occlusive dressings, wet-to-dry dressings, hydrogels, foam dressings, odor-controlling dressings, and xerogels.
Atypical Antipsychotic Pharmacokinetics
Chart Pharmacokinetics of Atypical Antipsychotics, including Bioavailability, Half-life and CYP 450 Metabolism.
Daily Dose Thresholds: Anxiolytics
Anxiolytic medications daily dose threshold chart, especially for long term care patients.
Daily Dose Thresholds: Antipsychotics
Antipsychotic daily dose threshold chart.
Thromboembolic Disorders: Treatments
Anticoagulants, antiplatelets, and thrombolytics for the treatment and/or prophylaxis of venous and arterial thrombosis.
Hypertension Treatment Algorithm
Management of hypertension in adults based on evidence-based guidelines.
Hypertension Evaluation
Blood pressure classification, diagnostic workup of hypertension, assess for major cardiovascular disease risk factors and identifiable causes, and blood pressure measurement techniques.
Hypertension Treatments: Diuretics
A comparative list of loop, potassium-sparing, and thiazide-like diuretics monotherapy and combination therapy for the treatment of hypertension.
Dyslipidemia Drug Indications
Comparative chart of single and combination treatment options indicating which lipids can be targeted for dyslipidemias.
Hypertension Treatments: ARBs
A comparative list of Angiotensin II Receptor Blockers (ARBs) monotherapy and combination therapy for the treatment of hypertension.
2021 Vaccination Schedule: 0-18 Years of Age
This schedule indicates the recommended ages for routine administration of currently licensed childhood vaccines for children 0-18 years of age.
2021 Vaccination Schedule: Adults
This schedule indicates the recommended age groups and medical indications for routine administration of currently licensed vaccines for persons 19 years and older.
Chronic Myeloid Leukemia: 5 Myths You May Encounter
Patients may not have much information on chronic myeloid leukemia, and some may have a number of misunderstandings surrounding the condition. As a health care professional, what are some of these myths you can correct to better educate patients?
Managing Cancer-Related Pain in Patients With Opioid Use Disorder
The patient’s prognosis should inform the decision to add full-agonist opioids to treatment.
Apatinib Improves PFS, OS in Radioactive Iodine-Refractory Thyroid Cancer
Apatinib improved progression-free survival regardless of baseline thyroglobulin levels.
Maternal Hormonal Contraception, CNS Tumors Not Linked in Children
No significant association was seen between maternal hormonal contraception use and CNS tumors in children younger than 20 years.
Prostate Cancer Death Risk Not Higher Among Black Men
New findings are consistent with recent pooled analyses in which adjustment for nonbiological differences, including socioeconomic status and health care access, eliminate the increased risk of death from prostate cancer observed in Black men.
Major Financial Hardship Prevalent in Metastatic Colorectal Cancer
At 12 months, the cumulative incidence of major financial hardship was 71.3%.
Severe Illness, Viral Coinfection Common in Children With COVID-19 Hospitalization
Only 1 of 272 vaccine-eligible pediatric patients hospitalized with COVID-19 was fully vaccinated.
BNT162b2 Vaccine Effectiveness 92 Percent for Teens Ages 12 to 17
The delta variant was the predominant SARS-CoV-2 strain at the time of the study.
Impact of Chronic Loneliness Similar to ‘Smoking a Half-Pack of Cigarettes a Day for Many Years’
Although the COVID-19 pandemic has exacerbated social isolation and loneliness among older adults, healthcare providers and payers are developing ways to address this growing challenge.
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