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A list of treatment options for HIV infection.
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Adult Participation in Cancer Trials Higher Than Previously Thought
Enrollment rates varied widely by study type and institution.
Risk of Cytokine Release Syndrome After CAR T-Cell Therapy May Vary by Ethnicity
Hispanic patients had significantly higher rates of severe cytokine release syndrome.
Oral Contraceptives
Progestin and estrogen content of oral contraceptives (birth control pills) chart.
Poziotinib Shows Promise in HER2 Exon 20-Mutant Non-Small Cell Lung Cancer
The confirmed response rate was 27%, and the median progression-free survival was 5.5 months.
Up-to-Date Evidence Confirms Pregnancy Possible After Surviving Breast Cancer
Meta-analysis results confirm that women can achieve a successful pregnancy after surviving breast cancer.
Research Assessment Seeks Evidence to Guide Treatment of MPN With COVID-19
Investigators assessed studies for evidence to guide the management of MPN in patients with COVID-19.
Salvage Autologous Stem Cell Transplantation May Improve Outcomes for Relapsed/Refractory Multiple Myeloma
Researchers sought to determine whether salvage therapy with high-dose chemotherapy followed by ASCT would improve survival in patients with MM.
Protection Against SARS-CoV-2 Wanes Months After BNT162b2 Vaccination
Two studies suggest declining effectiveness of the Pfizer-BioNTech COVID-19 vaccine.
Microaggressions and Lack of Tailored Resources: Challenges for LGBTQ+ Patients With Cancer
Survey responses revealed a lack of culturally competent care and tailored resources.
Proteins May Predict Lethal Prostate Cancer in African-American Patients
The proteins were only predictive for African-American patients, not European-American patients.
Higher Rate of Treatment Discontinuation Seen in Real-World Patients With Melanoma
Relapse-free survival outcomes were similar between real-world and clinical trial patients.
Verzenio Plus Endocrine Therapy Approved for HR+, HER2-, Early Breast Cancer
The approval is based on data from the phase 3 monarchE trial.
Keytruda Approved as First-Line Treatment for Persistent, Recurrent or Metastatic Cervical Cancer
The approval was based on data from the phase 3 KEYNOTE-826 trial.
Utilization Patterns Explain Nonadherence to Treatment for Multiple Myeloma, CML, Some Metastatic Cancers
A retrospective study of Medicare data showed a potential factor in nonadherence to oral cancer treatment regimens.
>140,000 U.S. Children Have Been Orphaned by COVID-19
The risk of losing a caregiver was 1.1 to 4.5 times higher among racial and ethnic minorities compared with non-Hispanic Whites.
Eligibility Criteria for Pancreatic Cancer Trials Exclude More Black Patients Than White Patients
Standard eligibility criteria perpetuate racial disparities and are often not medically justifiable, according to researchers.
Geriatric Assessment Tool Reduces Risk of Severe Adverse Events Related to Chemotherapy
The intervention also improved the rate of advance directive completion.
Cardiovascular Disease-Related Event Warnings May Be Common for Anticancer Drugs After FDA Approval
Cardiovascular disease-related warnings also took longer to be issued.
Study: 68Ga-PSMA-11 PET May Miss Pelvic Nodal Metastasis in Prostate Cancer
68Ga-PSMA-11 PET scans have a 40% sensitivity for detecting pelvic nodal metastasis in men with intermediate- or high-risk prostate cancer, data show.
Health Care Workers Show Greatest COVID-19 Stress
Stress levels during the first wave of the pandemic were 65.3 in medical doctors and 73.6 in paramedical staff (with 100 being the maximum stress level).
Model Shows Periodic MRIs Cost-Effective for Breast Cancer Screening
Screening with MRI alone every 4 years is cost-effective in women with extremely dense breasts.
Study Confirms Virulence of SARS-CoV-2 Variants of Concern
Risks for hospitalization, ICU admission, and death are higher with N501Y-positive variants and the delta variant.
Data Hide ‘Critical Disparities’ in Nasopharyngeal Carcinoma Incidence Among Asian Americans
The incidence was highest among Laotian and Chinese Americans.
Allostatic Load May Impact Treatment, Survival in Patients With Breast Cancer
Allostatic load was associated with a 14% increase in the risk of death.
Neoadjuvant Chemotherapy May Reduce Short-Term Mortality in Advanced Ovarian Cancer
Patients treated at facilities with a high use of neoadjuvant chemotherapy had greater declines in 1-year mortality rates over time.
Robotic-Assisted Radical Cystectomy Safe, Feasible for Octogenarians
The benefits of robotic surgery may have a more pronounced effect in octogenarians, according to investigators.
Lung Cancer Treatment May Impact Daily Function in Older Adults
Life-space assessments may help older adults better understand how cancer treatment impacts their lives, authors say.
AI Model Enhances Histologic Grading of Breast Cancer
A deep learning model provides independent prognostic information for stratification of Nottingham histologic grade 2 tumors.
Acute Myocarditis Rare After COVID-19 mRNA Vaccination in Adults
The incidence of myocarditis was 5.8 cases per 1 million adults after the second dose.
First-Line Immunotherapy Continues to Best Chemo in Malignant Pleural Mesothelioma
Data suggest nivolumab plus ipilimumab provides a long-term survival benefit in patients with unresectable malignant pleural mesothelioma.
Changes in Patient-Reported Outcomes Predict Response, Survival in Gastrointestinal Cancers
Treatment response, progression-free survival, and overall survival were all associated with patient-reported outcomes.
eNose Identifies Early Responders to Immunotherapy Among Non-Small Cell Lung Cancer Patients
The technology could save patients from ineffective treatment, according to researchers.
Patients With B-Cell Non-Hodgkin Lymphoma Treated With Anti-CD20 Antibodies Have Impaired Response to COVID-19 Vaccine
Researchers sought to determine whether patients with B-NHL who had treatment with anti-CD20 antibodies had an impaired serological response to an mRNA COVID-19 vaccine.
Method May Enable Noninvasive Lung Cancer Detection
The method involves DELFI, an approach that can detect many abnormalities in cfDNA through genome-wide analysis of fragmentation patterns.
Poor Prognosis Seen for Patients With B-Cell Acute Lymphoblastic Leukemia Progression After CAR-T Therapy
Researchers sought to determine whether patients with B-ALL who progress after CAR-T therapy would have a poor prognosis.
Pharmacies Often Not Notified of Discontinued Rx
Interventions, including phoning pharmacies and enabling CancelRX in electronic medical records, may reduce the risk of medication safety events.
Breast Cancer Patients Who Are Not Represented in Clinical Trials Have an Increased Risk of Death
The unrepresented patient population had a significantly increased risk of death at 5 years.
Surgery vs Radiation May Lower Risk of Death From High-Risk Prostate Cancer
In a large retrospective study, radical prostatectomy was significantly associated with a survival advantage among men with high-risk prostate cancer compared with external beam radiation therapy.
Autologous HSCT Provides Long-Term Survival Benefit in Mantle Cell Lymphoma
Transplant improved progression-free and overall survival at a median follow-up of 14 years.
Radiotherapy Deemed Safe in Vulvar Cancer Patients With Sentinel Node Micrometastasis
Researchers recommend implementing inguinofemoral radiotherapy in treatment guidelines for vulvar cancer.
Artificial Intelligence Boosts Colonoscopy Cancer Detection
Computer-aided polyp detection could decrease variability in colonoscopy quality.
Incidence of Keratinocyte Carcinoma Up From 2003 to 2017
The mortality rate of keratinocyte carcinoma was 1.8 times higher in men than women between 1998 and 2017.
Intranasal Corticosteroids Tied to Less Severe COVID-19 Outcomes
Intranasal corticosteroid therapy may lower the risk of severe COVID-19 outcomes.
Predicting End of Life for Patients With Metastatic Breast Cancer
Several factors were associated with 30-day mortality.
AI Quantifies Short-Term Death Risk, Aids Treatment Decisions for Advanced Cancer
The tool prompted significant increases in palliative care and hospice referrals.
Brentuximab Vedotin Provides ‘Robust Clinical Benefit’ in Cutaneous T-Cell Lymphoma
Time to next treatment was significantly longer with brentuximab vedotin.
Neoadjuvant Chemo May Improve Outcomes for MIBC of Variant Histology
Findings refute the notion that variant histology MIBC will not respond to neoadjuvant chemotherapy.
Tecartus Approved for Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia
The approval was based on data from the phase 1/2 ZUMA-3 trial.
Taxane-Containing Chemo Associated With Persistent Alopecia
Hair density improved with both topical and oral minoxidil, sometimes combined with antiandrogen therapy.
No Change Found in Pattern of Adverse Events After Third COVID-19 Shot
Rates of local and systemic reactions were similar after the second and third dose.
PSA Screening Recommendation Tied to Decrease in Prostate Cancer-Specific Survival
The 3-year prostate cancer-specific survival decreased significantly for insured patients.
Racial/Ethnic Disparities ID’d in Childhood Cancer Survival
Survival disparities decreased after adjustment for health insurance and area-level socioeconomic status.
Wearable Sensor Enables Early Detection of Febrile Adverse Events in Cancer Patients
The sensor detected fevers a median of 4.9 hours earlier than did standard care.
Patient Willingness to Travel for DLBCL Care Varies by Race, Other Factors
Patients with DLBCL may be willing to travel longer distances for treatment if follow-up care is local, but this pattern varies by race.
CADe Techniques to Detect Colorectal Cancer
Computer-aided detection techniques based on artificial intelligence algorithms were better able to detect colorectal neoplasia.
AI Could Improve Accuracy of Breast Ultrasound Diagnosis
The AI system achieved a higher AUROC than the average of 10 board-certified breast radiologists.
REGEN-COV Reduces Risk for COVID-19 Hospitalization, Death
In outpatients with COVID-19 at high risk of severe disease, the monoclonal antibody combination reduced the risk of hospitalization and death.
Hypertension Treatments: Diuretics
A comparative list of loop, potassium-sparing, and thiazide-like diuretics monotherapy and combination therapy for the treatment of hypertension.
Hypertension Treatments: ARBs
A comparative list of Angiotensin II Receptor Blockers (ARBs) monotherapy and combination therapy for the treatment of hypertension.
Patients With Cancer Should Receive COVID-19 Booster Shots
Researchers presented findings from CAPTURE, a prospective trial of COVID-19 vaccine or SARS-CoV-2-induced immunity in cancer patients.
Nomogram Could Aid Clinical Decision-Making for Gastroenteropancreatic Neuroendocrine Tumors
The nomogram proved more accurate than TNM staging for predicting 3-year and 5-year overall survival.
Causes, Strategies for Managing ED Visits by Patients With Solid Malignancies
A retrospective review identified the underlying cause for cancer patients’ emergency department visits.
An Analysis of Survival Trends With Allogeneic Blood and Marrow Transplantation
Researchers identified areas of improved outcomes for patients receiving allogeneic blood or marrow transplantation as well as some areas of concern.
FDA Clears New Technology for Computed Tomography Imaging
The NAEOTOM Alpha utilizes photon-counting detectors that measure each individual X-ray that passes through a patient’s body to create a detailed 3-dimensional image.
Revised Guidelines Perpetuate Disparities in Lung Cancer Screening
African-American and Hispanic patients remain less likely than White patients to be eligible for lung cancer screening.
FDA Panel to Discuss Boosters, COVID-19 Vaccine for Children in Upcoming Meetings
Background materials for both meetings will be available to the public.
Anaphylaxis Management
Anaphylaxis management for outpatients, inpatients, and patients at discharge.
How to Prevent a Cyberattack from Derailing Cancer Care
Cyberattacks on health care organizations may not be fully preventable, but there are ways to limit their impact on cancer care.
Real-World Data Support Same-Day Pegfilgrastim Prophylaxis to Reduce Febrile Neutropenia Risk
Investigators sought to determine if same-day administration of prophylactic pegfilgrastim was as effective as next-day administration.
Ivosidenib May Improve Survival in Advanced, IDH1-Mutated Cholangiocarcinoma
At the data cutoff, 70% of patients originally assigned to placebo had crossed over to the ivosidenib arm.
EHR Screening Reveals Financial Toxicity in Most Patients With Breast Cancer
Systematic screening of patients’ electronic health record helped identify those patients at risk of financial toxicity.
Survey Reveals Oncologists’ Preferences Regarding Scalp Cooling Therapy
Researchers identified patterns around usage of scalp cooling therapy to reduce the risk of chemotherapy-induced alopecia in patients.
Erbitux Plus Encorafenib Approved for BRAF V600E Mutation-Positive Metastatic Colorectal Cancer
The approval is supported by data from the phase 3 BEACON CRC trial.
COVID-19 Mortality Burden High Among Those 25 to 64 Years
Through March 13, 2021, the COVID-19 pandemic resulted in 9.08 million years of life lost in the United States.
Financial Burden Increasing for Privately Insured Cancer Patients
There was a significant increase in out-of-pocket costs for all 4 cancer types studied.
Androgen Signaling Inhibitors Appear More Effective in Luminal Metastatic Castration-Resistant Prostate Cancer
Patients with basal tumors did not derive a significant survival benefit from androgen signaling inhibitors.
Burnout in Oncologists: A ‘Failure of the Health System’
The odds of burnout were 15.5 times higher among physicians who reported a hectic or chaotic work atmosphere.
Meditation and Education Reduced Depression in Young Breast Cancer Survivors
Some improvements were sustained at 3 and 6 months of follow-up.
HPV Vaccine Will Have Modest Impact on Oropharynx Cancer Incidence by 2045
Reductions in oropharynx cancer incidence should be seen among young and middle-aged adults.
Individual Risk Assessment Ups Mammography in Women at High Risk
Use of mammography increased among women in racial and ethnic minority groups who were at high risk.
mRNA-1273 Continues to Be Efficacious at Five Months
Vaccine efficacy was 98.2% for preventing severe COVID-19.
Pembrolizumab and Olaparib Combination Therapy Shows Antitumor Activity and Acceptable Safety for Pretreated mCRPC
The nonrandomized, multicenter, multicohort, open-label, phase 1b/2 KEYNOTE-365 trial evaluated the safety, tolerability, and efficacy of pembrolizumab combination therapy in men with mCRPC.
Castration Resistance-Free Survival With Relugolix vs Leuprolide in Advanced Prostate Cancer
CRFS after relugolix was not significantly different compared with leuprolide in men with advanced prostate cancer and metastatic disease.
Androgen Deprivation Therapy Exposure Linked to Increased Risk of Dementia After Prostate Cancer
ADT exposure after prostate cancer treatment is associated with the onset of dementia.
Radiotherapy for Prostate Cancer Associated With Long-Term Complications
RT for prostate cancer is associated with distinct treatment-related complications such as cystitis and urinary stricture.
Real-World Apalutamide and Enzalutamide Rate of Treatment Discontinuation From AEs Higher Than in Clinical Trials for nmCRPC
Treatment discontinuation from adverse events in real-world use is 32% higher for apalutamide and 49% higher for enzalutamide than reported in clinical trials of patients with non-metastatic castration-resistant prostate cancer.
Medical Billing Outsourcing Is on the Rise
Contracting with outside firms to handle medical billing can be a smart financial move for some medical practices.
Pretreatment ctDNA Predicts Survival in Non-Small Cell Lung Cancer
PD-L1 expression and tumor mutational burden were not associated with survival.
Method Identifies Cancer Patients Who Benefit From Early Palliative Care
Patients who received early palliative care had improvements in symptom control and mood over time.
Overall Cancer Incidence, Mortality Lower for U.S. Hispanics
Higher rates of infection-related cancers were seen among Hispanic individuals.
Artificial Intelligence May Speed Lung Cancer Detection
The AI technology was tested on 1,179 patients in a lung screening trial.
Urban-Rural Disparity Seen in New Liver Cancer Cases
There was a higher average annual percentage change in incidence for rural vs urban areas between 1995 and 2016.
Vaccines Effective in Preventing Symptomatic COVID-19 in Health Care Workers
Vaccine effectiveness was 88.8% for Pfizer-BioNTech and 96.3% for Moderna.
Global Impact of COVID-19 on Enrollment in Lung Cancer Trials
Enrollment declined 43% from 2019 to 2020.
Family History of CCIS Linked to Increased Risk of Invasive Colorectal Cancer
The findings suggest a need to modify colorectal cancer screening.
Socioeconomic Status Does Not Predict Survival in Mesothelioma
Factors associated with poor survival were advanced age and male sex.
Survival Up With Tebentafusp in Metastatic Uveal Melanoma
Tebentafusp bested investigator’s choice of therapy in patients with previously untreated, metastatic uveal melanoma.
CAD Risk Up With Radiation Treatment for Left-Sided Breast Cancer
The risk for coronary artery disease was increased for young women receiving radiation for left- vs right-sided breast cancer.
Artificial Intelligence Better Than Risk Factors for Predicting Cancer Risk
The deep learning model outperformed other models.
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