Hypertension Treatments: Oral CCBs
Oral calcium channel blockers (CCBs) for the treatment of hypertension including benzothiazepines, dihydropyridines, and diphenylalkylamines.
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FDA-Approved Ovarian Cancer Treatments
FDA-Approved treatment options for individuals with ovarian cancer including dosing.
Survival Rates Not Improving for AYAs With Sarcomas or Breast, Gynecologic Cancers
Survival improvements were noted in brain and nervous system cancers, colorectal cancers, and lung cancer.
Five-Year Extended Hormone Therapy No Better in Breast Cancer
Findings compared with two years of extended adjuvant anastrozole in postmenopausal women with hormone-receptor-positive breast cancer.
Healthy Lifestyle May Offset Genetic Risk for Cancer
For men and women with high genetic risk, five-year cancer incidence down significantly with a favorable lifestyle.
Pyrotinib Plus Capecitabine Prolongs PFS in HER2-Positive Metastatic Breast Cancer
Pyrotinib plus capecitabine bested lapatinib plus capecitabine in a phase 3 trial.
‘Harmful’ Articles on Cancer Treatment Get More Engagement on Social Media
About 31% of the articles analyzed contained information classified as harmful.
Ipilimumab Plus Nivolumab Improves Survival in Melanoma With Brain Metastases
Combination ipilimumab and nivolumab reduced the risk of death by 56% when compared with fotemustine monotherapy.
Patient Perception of Outcomes Associated With Psychosocial Function After Reconstruction for Head and Neck Cancer
Survey-based study determined the association between patients’ perception of aesthetic outcome and psychosocial function after undergoing ablation with this complex procedure.
Can Patients With Multiple Myeloma Boost Their Immunity?
Multiple myeloma (MM) is not a disease with a known cure, but recent studies have suggested that focusing on boosting immunity in patients with MM may help their chances at longer-term survival. What are these immunity-focused treatment options?
TVUS ET Screening Misses More Cases of Endometrial Cancer in Black Women Than in White Women
The disparity is due to the greater prevalence of fibroids and nonendometrioid histologic type in Black women, according to researchers.
Racial Disparities Persist in Multiple Myeloma Care, Outcomes
Hispanics have higher MM-related in-hospital mortality; recent decline seen in in-hospital mortality for all except NH-Blacks.
KRAS G12C Mutations in Metastatic Colorectal Cancer: Questions Remain
Dr Alan Lyss reviews studies of KRAS G12C mutations in metastatic colorectal cancer.
Oxaliplatin-Based Hyperthermic Intraperitoneal Chemotherapy in Patients With Colorectal Peritoneal Metastases
Oxaliplatin-based hyperthermic intraperitoneal chemotherapy showed no OS benefit compared with cytoreductive surgery in patients with colorectal peritoneal metastases.
Radiotherapy Plus Trastuzumab Did Not Significantly Reduce Ipsilateral Breast Tumor Recurrence Rate in HER2+ DCIS
In the B-43 phase 3 trial, researchers did not achieve the objective of a 36% reduction in ipsilateral breast cancer rate with the addition of trastuzumab to radiotherapy.
Lobaplatin-Based Regimen May Be ‘Promising’ Alternative for Nasopharyngeal Carcinoma
Treatment-related toxicities were less likely with the lobaplatin-based regimen.
FDA-Approved Non-Small Cell Lung Cancer (NSCLC) Treatments
Chemotherapeutic and biologic agents for the treatment of non-small cell lung cancer (NSCLC).
Floxacin Antibiotics May Augment Treatment of Lung and Bladder Cancers by Inhibiting RSK4
RSK4-targeting floxacins could boost the efficacy of chemotherapy.
Surgery May Improve Survival in Older Patients With Invasive Breast Cancer
Surgery was an independent predictor of overall survival.
Long-Term Aspirin Use Before Diagnosis May Reduce Risk of Death From Colorectal Cancer
Aspirin may prevent distant metastases, according to researchers.
Prostate Cancer Surgery Lagged for Black Men During Pandemic
Black men less likely than White men to undergo prostatectomy despite similar COVID-19 risk factors, biopsy Gleason grade groups.
Calaspargase and Pegaspargase Produce Comparable Results in Newly Diagnosed Acute Lymphoblastic Leukemia
Efficacy and toxicity outcomes were similar with calaspargase and pegaspargase.
Cryopreservation of Unrelated Donor SCTs Safe, Effective in Patients Who Underwent HSCT
Researchers sought to determine whether cryopreservation of unrelated donor hematopoietic stem cells would affect outcomes in patients who underwent HSCT since the COVID-19 pandemic.
Risk of Cardiovascular Death in Patients With Primary Central Nervous System Lymphoma
Risk of CVD death is lower with PCNSL than with extra-central nervous system lymphoma; however, the risk with this rare non-Hodgkin lymphoma is uncertain.
Treatment Strategies and Challenges in Chronic Lymphocytic Leukemia
Researchers sought to clarify the current treatment strategies and challenges for patients with chronic lymphocytic leukemia.
FDA-Approved Breast Cancer Treatments
FDA-approved oral and injectable treatment options for breast cancer.
FDA-Approved Colorectal Cancer Treatments
Colorectal cancer treatment regimen chart.
Medicinal Cannabis Improves Quality of Life for Patients With High-Grade Gliomas
A 1:1 ratio of THC to CBD proved superior to a 4:1 ratio.
Addition of Pembrolizumab ‘Should Be New Standard of Care’ for Early Triple-Negative Breast Cancer
Pembrolizumab improved pathologic complete response rates and event-free survival.
Keytruda Combo Approved for High-Risk Early-Stage Triple-Negative Breast Cancer
The approval was based on data from the phase 3 KEYNOTE-522 trial, which included 1174 patients with newly diagnosed previously untreated high-risk early-stage TNBC.
Medical Groups Call for Mandatory COVID-19 Vaccination for Health Care Workers
Mandatory vaccination is especially crucial to protect vulnerable people, including unvaccinated children and those with weakened immune systems.
Vandetanib and Cabozantinib Deemed Effective in Real-World Study of Medullary Thyroid Cancer
The overall survival rate at 1 year was 86% with vandetanib and 70% with cabozantinib.
Carboplatin Intensification Beneficial for Group 3 Medulloblastoma
Therapy intensification with carboplatin improved five-year event-free survival in children with high-risk group 3 medulloblastoma only.
Geographic Disparities Found in Cancer Diagnosis Stage, Mortality for AYAs
Living in rural counties and living farther from reporting hospital detrimental for adolescents and young adults with cancer.
Wound Care Products
Wound care dressings and cleansers including hydrocolloid occlusive dressings, wet-to-dry dressings, hydrogels, foam dressings, odor-controlling dressings, and xerogels.
Oral Contraceptives
Progestin and estrogen content of oral contraceptives (birth control pills) chart.
Subcutaneous Daratumumab Associated With Reduced Active Provider Time for Patients With Multiple Myeloma
Researchers sought to determine whether subcutaneous daratumumab would require less HCP time and would be a more efficient method for administering the drug.
Solid Organ Transplant Linked to Reduced Overall Survival, Not Cancer-Specific Survival
The findings support current management strategies for cancer patients, according to researchers.
Racial/Ethnic Minorities Have Higher Risk of Familial-Associated Early-Onset Cancer
The study showed differences by cancer type and race/ethnicity.
Cemiplimab Deemed Active, Safe After HHIs in Locally Advanced Basal Cell Carcinoma
Phase 2 trial results supported the approval of cemiplimab for this patient group.
Novel Genetic Variants Are Associated With Increased Risk of Cervical Cancer
Genetic variations in the PAX8, CLPTM1L, and HLA genes were found to be associated with a high risk of developing cervical cancer.
Remote Monitoring System Reduces Chemotherapy Symptom Burden
Significant reductions seen for global distress index, psychological symptoms, physical symptoms of Memorial Symptom Assessment Scale.
Antiretroviral Treatments
A list of treatment options for HIV infection.
No Survival Benefit With Primary Tumor Resection in Stage IV Colorectal Cancer
Phase 3 results refute findings from retrospective studies.
Experts Review the State of Colorectal Cancer Screening in the COVID-19 Era
Two experts discuss the future of colorectal cancer screening and lessons learned during the era of COVID-19.
Loncastuximab Tesirine ‘Could Change Practice’ for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
The antibody-drug conjugate demonstrated durable antitumor activity in heavily pretreated patients.
Ipatasertib Plus Abiraterone: A New Potential Treatment for Metastatic Castration-Resistant Prostate Cancer With PTEN Loss
The combination improved progression-free survival.
Bempegaldesleukin Plus Nivolumab Elicits Responses in Treatment-Naïve, Advanced Melanoma
More than half of patients responded, and responses deepened over time.
Risk for Psoriasis Increased for Cancer Survivors
Increased risks seen for survivors of leukemia, lymphoma, multiple myeloma, skin cancer, and lung cancer in subgroup analyses.
Nomograms May Aid Patient Selection for 177Lu-PSMA Therapy in Metastatic Castration-Resistant Prostate Cancer
The nomograms predicted overall and progression-free survival.
Extended Bisphosphonate Treatment Does Not Improve Survival in High-Risk Early Breast Cancer
There was no benefit to extending zoledronate treatment beyond 2 years.
How to Prevent COVID-19 Vaccination From Interfering With Cancer Imaging
Education, communication, and coordination are key.
SBRT Proved Better Than EBRT for Alleviating Pain in Cancer Patients With Spinal Metastases
Stereotactic body radiotherapy more than doubled the complete response rate.
Keytruda Plus Lenvima Gets Full Approval for Advanced Endometrial Cancer
The full approval was based on data from the confirmatory phase 3 KEYNOTE-775 trial.
Carfilzomib Therapies Effective for Patients With Relapsed/Refractory Multiple Myeloma
Researchers sought to determine whether combination therapies with carfilzomib would be feasible for patients with relapsed/refractory multiple myeloma.
Removing a Large Uterus via Minimally Invasive Surgery Linked to Local Recurrence of High-Grade Endometrial Cancer
The results raise concern about potential local tumor spill, according to researchers.
Regimen Deemed Safe, Effective as Bridge to Transplant in Relapsed/Refractory Classical Hodgkin Lymphoma
The overall response rate was 100%.
Cost of Care a Substantial Burden for Fee-for-Service Medicare Recipients With Multiple Myeloma
Researchers sought to assess the disease-specific costs for Medicare recipients with multiple myeloma.
No Survival Benefit With Pembrolizumab in Advanced Urothelial Carcinoma
Platinum-based chemotherapy should remain the standard of care, according to researchers.
Germline Testing Reveals Actionable Mutations in Advanced Cancers
Therapeutically actionable germline variants were found in 8% of patients with advanced cancers.
Better Patient-Reported Outcomes With Atezolizumab Plus Bevacizumab in Hepatocellular Carcinoma
The combination bested sorafenib.
Local Resection Is ‘Sufficient’ for Parathyroid Carcinoma
Patients with parathyroid carcinoma after localized resection for a presumed benign indication should undergo close monitoring for recurrence rather than radical surgery.
Study Supports FOLFOX as Standard Second-Line Treatment for Advanced Biliary Tract Cancer
FOLFOX provided a benefit over active symptom control.
Older Patients With NHL at High Risk for Treatment-Related Toxicity Events
A retrospective study revealed age-based risks for toxicities in patients with NHL treated with high-dose chemotherapy and autologous hematopoietic cell transplantation.
Avelumab Doesn’t Improve Survival in Platinum-Refractory Ovarian Cancer
There was no improvement in progression-free or overall survival.
Seroconversion After Full COVID-19 Vaccination Lower With Hematologic Malignancies, Lowest With Multiple Myeloma
A single-center study found anti-COVID-19 protection lowest in patients with MM at 2 weeks after their second BNT162b2 mRNA shot than did patients with myeloproliferative malignancies, and was highest in older patients without cancer.
Unmet Social Needs, Distress Linked in Gynecologic Oncology Patients
Social isolation and lack of safety at home associated with distress; unmet needs also linked to treatment interruption.
Plasma Biomarkers May Help Target CAR-T Therapy for Multiple Myeloma
Researchers sought to determine whether plasma biomarkers may help enhance CAR-T therapy for patients with multiple myeloma.
Overcoming Obstacles to Health Equity in Breast Cancer Prevention and Control
The current scientific evidence may not be generalizable to underrepresented groups.
Stopping Ipi/Nivo for irAEs Did Not Affect Advanced Melanoma Survival
Immune-related adverse events were associated with improved survival outcomes.
CPX-351 May Provide Survival Benefit in Older Patients With High-Risk or Secondary Acute Myeloid Leukemia
The 5-year survival rate was longer with CPX-351 than with conventional chemotherapy.
Donafenib Bests Sorafenib in Chinese Patients With Advanced Hepatocellular Carcinoma
Overall survival was superior with donafenib.
Study Looks at Cancer Cases Attributable to Alcohol Use
In 2020, an estimated 4.1 percent of all new cancer cases globally attributed to alcohol consumption.
Real-World Analysis of Renal Function in Patients With Multiple Myeloma
Researchers sought to determine the real-world renal function and outcomes for patients with multiple myeloma according to type of treatment and line of therapy.
MRI Can Avoid Unnecessary Prostate Biopsies Among Screened Men
In a trial of men who volunteered for PSA screening, detection of clinically insignificant tumors and benign findings were reduced when prostate biopsy was performed only in those with positive MRI results.
BRAF Mutant Allele Fraction May Predict Survival in Metastatic Colorectal Cancer
When researchers combined clinical features with BRAF mutant allele fraction, patients could be divided into 3 risk groups that were significantly associated with survival.
Pembrolizumab Provides Durable Survival Benefit in Metastatic Non-Small Cell Lung Cancer With High PD-L1 Expression
The 5-year survival rate was superior with pembrolizumab.
Ofatumumab Plus Bendamustine Does Not Confer a Survival Benefit in Indolent Non-Hodgkin Lymphoma
Progression-free and overall survival outcomes were similar with and without ofatumumab.
Mortality Risk Factors in Patients With Cancer and COVID-19 Identified
Investigators zero in on mortality risk factors in patients with cancer who contract COVID-19.
Therapeutic Drug Monitoring Improved Incidence of Pleural Effusion With Dasatinib for CP-CML
A dose-reduction strategy in patients with CP-CML receiving dasatinib was shown to be feasible and may reduce adverse effects in these patients.
Photodynamic Diagnosis Ups Detection of BCG-Refractory Bladder Tumors
Photodynamic diagnosis cystoscopy demonstrates greater sensitivity in the detection of BCG-refractor bladder tumors compared with standard white light cystoscopy.
Factors ID’d for Radiologist Performance in Screening Mammography
Geographic location of radiology practice, breast subspecialization, performing diagnostic mammography tied to radiologist performance.
Survival Odds Similar After Open, Robotic-Assisted Radical Cystectomy
Researchers in The Netherlands compared the surgical approaches in patients with muscle-invasive or high-risk nonmuscle-invasive bladder cancer.
Disparities in Breast Cancer Survival Persist for Black Women
Although nearly all metrics improved for racial-ethnic minorities, recent breast cancer-related mortality in Florida still higher in Black women.
Study: Risk Score Should Guide Deferral of Cytoreductive Nephrectomy
Ideal patient selection for a deferred cytoreductive nephrectomy should include an assessment of Memorial Sloan Kettering Cancer Center risk score, according to investigators.
Pain Severity and Health-Related Quality of Life With Multiple Myeloma
Researchers sought to determine whether poorer health-related quality of life would be linked to responses about pain severity in patients with multiple myeloma.
PSMA-PET/CT May Detect Prostate Cancer More Accurately Than mpMRI
Early results support a fully-powered trial of 18F-PSMA PET/CT for prostate cancer detection, according to the investigators.
Pathologic Outcomes in Prostate Cancer Cases Worsened During Pandemic
Compared with before the pandemic, men undergoing radical prostatectomy during the pandemic were more likely to have extraprostatic disease, according to investigators.
Patients With MPN and Their Caregivers Could Benefit from Greater Support, Interventions
During a residential rehabilitation program, researchers interviewed participants to determine their supportive care and rehabilitation needs.
Perceived Financial Barriers Hinder Cervical Cancer Screening
72 percent of low-income, uninsured, or publicly insured women perceived financial barriers to screening.
Trastuzumab Emtansine in Stage I HER2+ Breast Cancer
Among patients with stage I HER2+ breast cancer, adjuvant treatment with T-DM1 was associated with “excellent” 3-year iDFS, but was not associated with fewer clinically relevant toxicities compared with paclitaxel plus trastuzumab.
Platinum Chemotherapy Appears to Cause Clonal Expansion Leading to Myeloid Neoplasms in Children With Neuroblastoma
Children treated for neuroblastoma developed myeloid neoplasms with specific platinum chemotherapy-associated mutation signatures.
Front-Line Cemiplimab Monotherapy May Improve Survival In Advanced NSCLC
Cemiplimab monotherapy improved OS and PFS compared with chemotherapy in patients with advanced NSCLC with PD-L1 of at least 50%.
Dose Capping May Explain Reduced Survival in Patients With Colorectal Cancer and High BMI
The results suggest a link, but more research is needed.
Photodynamic Diagnosis May Reduce NMIBC Recurrence Rates
Before PDD TURBT can be adopted into clinical practice, a large pragmatic trial is needed, according to investigators.
HDMTX Promising for Patients With Primary CNS Lymphoma Ineligible for Clinical Trials
Researchers compared outcomes in patients with PCNSL who did not meet clinical trial criteria with those of patients from a major multicenter clinical trial of PCNSL.
Acalabrutinib Seems Safe and Efficacious in Patients With Treatment-Naïve Chronic Lymphocytic Leukemia
Researchers sought to determine whether acalabrutinib would be safe and effective in patients with treatment-naïve CLL who declined or were in ineligible for chemotherapy.
Apalutamide Prolongs Survival in mCSPC Regardless of Disease Volume
A final analysis of the TITAN trial shows that apalutamide vs placebo added to ADT significantly lowers the risk of death and castration-resistant disease in men with metastatic castration-sensitive prostate cancer.
Carbogen and Nicotinamide With Radiation Feasible for Bladder Cancer
Trial involving seven patients with locally advanced bladder cancer shows concurrent CON with radiation therapy feasible in Australia.
Ovarian Stimulation Drugs Not Tied to Higher Breast Cancer Risk
Use of clomiphene citrate or gonadotropins, alone or in combination, not associated with increased risk for breast cancer.
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