ART and Pediatric Cancer: Risk May Vary by Method Used, Cancer Type
Research has suggested that ART may increase the risk of pediatric cancers, but studies have shown conflicting results, and questions remain.
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Uterine Cancer Mortality on the Rise, but Research Remains Underfunded
Though mortality rates for uterine cancer are on the rise, research for this cancer is underfunded, a study suggests.
Most Patients Prefer to Receive Test Results Through Online Portal
About 96% of survey respondents said they preferred to receive test results immediately through the online portal.
PIK3CA and ARID1A May Be Therapeutic Targets in Advanced Cervical Cancer
PIK3CA and ARID1A may be targets for drug development in recurrent or metastatic cervical cancer, according to researchers.
Keytruda Granted Full Approval for Advanced MSI-H or dMMR Solid Tumors
The conversion from accelerated approval to regular approval was based on data from the KEYNOTE-158 trial, the KEYNOTE-164 trial, and the KEYNOTE-051 trial.
More Lines of Chemotherapy Linked to Higher Risk of VTE in Ovarian Cancer
New research suggests that, for patients with ovarian cancer, the risk of VTE increases as patients receive more lines of chemotherapy.
Osemitamab Gets Orphan Drug Status for Pancreatic Cancer
The orphan drug designation for osemitamab is supported by preliminary antitumor activity observed in a phase 1/2a trial.
Abortion Restrictions May Affect More than 20% of Pregnant Cancer Patients in the US
More than 20% of US patients diagnosed with cancer during pregnancy may be unable to terminate that pregnancy due to abortion laws in their state, a new study suggests.
Zolbetuximab Plus Chemo Deemed New Standard Care for Gastric/GEJ Cancer
Adding zolbetuximab to chemotherapy improves survival outcomes in patients with unresectable or metastatic gastric/GEJ cancer, a study suggests.
Time Spent on Health Care for Endometrial Cancer Negatively Affects Quality of Life
Patients with advanced or recurrent endometrial cancer spend about 15% of their time addressing health care needs, and this time burden can have a negative effect on their quality of life, a study suggests.
Processed Red Meat Intake Linked to Increased Incidence of AML/MDS
Processed red meat intake is associated with an increased incidence of AML and MDS in a Japanese population, a study suggests.
Modifying Use of Prostate MRI and Biopsy Could Reduce Environmental Impact
The environmental impact of prostate MRI and biopsies may be considerable, a study suggests.
MRD Status Linked to Time to Next Treatment in MM
Patients with sustained minimal residual disease negativity had longer time to next treatment, regardless of baseline risk characteristics.
Clinical Trial: Sotorasib Plus Panitumumab in KRAS p.G12C-Mutated Metastatic Colorectal Cancer
Researchers are conducting a phase 3 trial to compare sotorasib plus panitumumab with investigator’s choice of therapy in patients with previously treated, KRAS p.G12C-mutated metastatic colorectal cancer.
Clinical Trial: Tucatinib, Trastuzumab, and Chemo vs Standard Care in HER2+ CRC
Researchers are conducting a phase 3 trial to compare standard care with combination tucatinib, trastuzumab, and chemotherapy as first-line treatment in HER2-positive, unresectable or metastatic colorectal cancer.
Clinical Trial: Comparing Nivo, Ipi-Nivo, and Chemo in MSI-H/dMMR Metastatic Colorectal Cancer
Researchers are comparing nivolumab monotherapy, nivolumab plus ipilimumab, and investigator’s choice of chemotherapy in MSI-H/dMMR, recurrent or metastatic colorectal cancer.
Clinical Trial: XL092 Plus Atezolizumab vs Regorafenib in Metastatic CRC
Researchers are conducting a phase 3 trial to compare XL092 plus atezolizumab with regorafenib alone in MSS/MSI-low metastatic colorectal cancer.
Minimally Invasive Surgery Linked to Longer Survival in Advanced Ovarian Cancer
Patients with advanced ovarian cancer may live longer if they undergo minimally invasive surgery rather than laparotomy, a study suggests.
Overall Survival Similar With or Without Niraparib Maintenance in Ovarian Cancer
Niraparib maintenance does not improve overall survival in patients with platinum-sensitive recurrent ovarian cancer, updated data suggest.
Dostarlimab Plus Chemo Deemed New Standard Care for Endometrial Cancer
Adding dostarlimab to chemotherapy can improve outcomes in patients with primary advanced or recurrent endometrial cancer, a phase 3 trial suggests.
Durvalumab, Tremelimumab, and Chemo Deemed Active in Advanced Ovarian Cancer
The combination of durvalumab, tremelimumab, and chemotherapy can produce durable responses in patients with newly diagnosed, advanced-stage epithelial ovarian cancer, a phase 2 trial suggests.
Adavosertib Appears Active but Toxic in Advanced Uterine Cancer
Adavosertib is active but not well tolerated in patients with recurrent or persistent uterine serous carcinoma, a phase 2 study suggests.
Pembrolizumab Improves PFS in Advanced, Recurrent Endometrial Cancer
Adding pembrolizumab to chemotherapy improves progression-free survival in advanced or recurrent endometrial cancer, a phase 3 trial suggests.
Adding Anlotinib to Pembrolizumab Improves PFS in Ovarian Cancer
Anlotinib enhances the efficacy of pembrolizumab in patients with recurrent or refractory high-grade serous ovarian cancer, a phase 2 study suggests.
No Difference Between Chemoradiotherapy and Chemo Alone in Endometrial Cancer
Chemoradiotherapy does not improve overall survival, compared with chemotherapy alone, in patients with locally advanced endometrial cancer, a phase 3 trial suggests.
Toripalimab, Bevacizumab, and Chemo Deemed Effective in Advanced Cervical Cancer
The combination of toripalimab, bevacizumab, and platinum-based chemotherapy appears safe and effective for patients with advanced cervical cancer.
Clinical Trial Participation Linked to Longer OS in Platinum-Resistant Ovarian Cancer
Patients with platinum-resistant epithelial ovarian cancer may have better overall survival if they enroll on a clinical trial than if they receive standard care.
54 Million US Women May Lack Access to a Gynecologic Oncologist
The number of gynecologic oncologists in the US has grown in recent years, but many patients still lack access to a gynecologic oncologist.
Reimbursement for Gynecologic Oncology Procedures Has Not Kept Up With Inflation
Physician reimbursement rates for gynecologic oncology procedures have increased in recent years but have not kept up with inflation, a study suggests.
Gemcitabine Plus Cisplatin and IMRT Produces Complete Responses in Vulvar Cancer
The combination of gemcitabine, cisplatin, and IMRT appears effective in patients with locally advanced, unresectable vulvar cancer.
Cryocompression May Reduce Peripheral Neuropathy in Gynecologic Cancer
Cryocompression can reduce subjective peripheral neuropathy in patients with gynecologic cancer undergoing chemotherapy, a study suggests.
Ribociclib Plus Letrozole Yields Responses in Recurrent Ovarian Cancer
Ribociclib plus letrozole elicits responses in patients with recurrent low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum, a phase 2 study suggests.
Characteristics, Treatment Options for Patients With Advanced Gynecologic Cancers
The management of advanced gynecologic cancers remains a challenge, but the treatment landscape is changing.
Progestogen-Only Contraceptives Linked to Higher Risk of Breast Cancer
Researchers found a similarly increased risk of breast cancer for progestogen-only contraceptives and oral combined contraceptives.
Molecular Testing May Be Underused, Delaying Therapy in Metastatic NSCLC
Molecular testing may be underused in patients with metastatic NSCLC and may delay the start of systemic therapy, a study suggests.
US Saw 30% Increase in Drug Shortages in 2022, Senate Report Shows
Drug shortages in the United States increased nearly 30% between 2021 and 2022, according to a Senate report.
Zynyz Approved for Metastatic or Recurrent Locally Advanced Merkel Cell Carcinoma
The FDA has granted accelerated approval to Zynyz (retifanlimab) for the treatment of adults with metastatic or recurrent locally advanced Merkel cell carcinoma.
Residual Variants May Predict Relapse, Death in AML
Residual variants are associated with a higher risk of relapse and death among AML patients undergoing HSCT in first remission, a study suggests.
Mammography Use Remains Low in American Indian Women
Mammography use is still higher among White patients than among American Indian patients, but the gap is narrowing due to declining mammography use in White patients.
Antibiotics May Prevent Chemoresistance in Metastatic Pancreatic Cancer
Antibiotics may prevent bacteria-mediated chemoresistance in patients with metastatic pancreatic cancer, a new study suggests.
COVID-19 Vaccines Deemed Safe for Patients With Solid Tumors
Patients with solid tumors do not appear to have an increased risk of side effects from COVID-19 vaccination, according to a systematic review.
Adding Ipilimumab to Standard Care Improves Responses in Operable NSCLC
Adding ipilimumab to nivolumab and chemotherapy improves responses in patients with operable non-small cell lung cancer, a phase 2 trial suggests.
Pentagon Study Finds Higher Cancer Rates Among Pilots, Ground Crews
Military pilots and the ground crews who fuel and maintain their aircraft have higher rates of certain cancers, a new study shows.
Trial Investigating Pembrolizumab for Hormone-Sensitive Prostate Cancer Discontinued
Merck has decided to end the phase 3 KEYNOTE-991 trial due to futility.
Ulenistamab Fast Tracked for Advanced/Metastatic Pancreatic Cancer
Ulenistamab targets PAUF, a tumor-specific protein that is overexpressed in pancreatic cancer cells.
Adverse Birth Outcomes More Common Among AYAs With Cancer During Pregnancy
Adolescent and young adult patients diagnosed with cancer during pregnancy have a higher risk of adverse birth outcomes, a study suggests.
Comparable Outcomes With and Without Neoadjuvant Therapy in High-Risk Melanoma
Patients with high-risk, stage III melanoma have similar outcomes whether they undergo surgery upfront or receive immunotherapy prior to surgery, a study suggests.
Surgical Resection Improves Long-Term Outcomes in T1 Colorectal Cancer
Surgical resection generally improves long-term outcomes over local resection in high-risk, T1 colorectal cancer, a study suggests.
Hormone Therapy Linked to Lower Risk of Lung Cancer in Postmenopausal Women
Patients receiving higher doses of hormone therapy and those receiving hormone therapy for at least 5 years may have a lower risk of lung cancer.
Discrimination Tied to Frailty in African-American Cancer Survivors
Among African-American cancer survivors, experiencing discrimination is associated with frailty, a study suggests.
Nicotinamide Does Not Prevent Keratinocyte Cancers in Organ Recipients
Oral nicotinamide does not reduce the risk of keratinocyte cancers in organ transplant recipients, a study suggests.
Basal Cell Carcinoma: A Review
Authors present a concise overview of the diagnosis, risk factors, and treatment of basal cell carcinoma.
Low-Dose Tamoxifen Reduces Risk of Breast Cancer Long-Term
Low-dose tamoxifen reduces the risk of breast cancer among patients with intraepithelial neoplasia for several years, data suggest.
High Rate of Hand-Foot Syndrome After Chemotherapy in CRC Patients
The prevalence of hand-foot syndrome after chemotherapy is high among patients with colorectal cancer, according to researchers.
Metastasis-Directed Therapy Protective in Recurrent Prostate Cancer
New findings could have implications for the use of salvage therapies.
Positive Surgical Margins Linked to Worse RCC Recurrence, Survival Rates
Findings may inform treatment decisions after nephrectomy with positive surgical margins.
Past-Due Medical Debt in Nonelderly Adults
About 15% of nonelderly US adults surveyed said they or their families have past-due medical debt.
Patterns of COVID-19 Vaccination in Cancer Patients Who Already Had COVID-19
Several factors influenced the likelihood of COVID-19 vaccination among patients with cancer who already had COVID-19, a new study suggests.
Vistusertib Provides No Benefit in Platinum-Resistant/Refractory Ovarian Cancer
Adding vistusertib to treatment with paclitaxel does not improve outcomes in patients with platinum-resistant or -refractory ovarian cancer, a phase 2 trial suggests.
Survival Improving in Metastatic Bladder Cancer
The median survival for patients with metastatic bladder cancer is increasing, possibly due to increasing use of immunotherapy.
Postoperative AEs Delay Chemotherapy but Do Not Affect Survival in Ovarian Cancer
Postoperative adverse events can delay chemotherapy but do not affect survival outcomes in patients with platinum-sensitive, recurrent ovarian cancer, a study suggests.
Tafinlar Plus Mekinist Approved for Pediatric BRAF V600E Low-Grade Glioma
The FDA approved the combination to treat pediatric patients 1 year of age and older who have low-grade glioma with a BRAF V600E mutation and require systemic therapy.
US Proposes Reducing PFAS in Drinking Water
A proposed regulation would require US public water systems to reduce the level of PFAS in drinking water.
Clinical Trial: Adding Vorinostat to Pembrolizumab and Tamoxifen in ER+ Breast Cancer
Researchers are conducting a phase 2 trial to test pembrolizumab and tamoxifen, with or without vorinostat, in patients with ER+ breast cancer.
Clinical Trial: Valemetostat Plus Trastuzumab Deruxtecan for HER2-Low Metastatic Breast Cancer
Researchers are testing valemetostat plus trastuzumab deruxtecan in patients with HER2-low/ultra-low/null metastatic breast cancer.
Clinical Trial: Tucatinib Plus Alpelisib in PIK3CA-Mutant, HER2+ Breast Cancer
Researchers are conducting a phase 1b/2 trial to test tucatinib plus alpelisib in patients with advanced, PIK3CA-mutant, HER2+ breast cancer.
Clinical Trial: CAR-T Cells in Mesothelin-Expressing Triple-Negative Breast Cancer
Researchers are conducting a phase 1 trial to test CAR T-cell therapy in patients with mesothelin-expressing triple-negative breast cancer.
The Cost of Bladder Cancer Care Is Rising. Could Value-Based Care Models Help?
The rising cost of care is having a negative impact on patients with bladder cancer, but a value-based approach to care might provide some relief.
Robust Breast Cancer Patients Have Higher Risk of Worsening Frailty Status
Non-frail patients with early-stage breast cancer have an increased risk of worsening frailty status after locoregional therapy, a study suggests.
Surgery, Radiation Therapy Offer Similar Survival in High-Risk Prostate Cancer
Investigators analyzed data from 3 randomized controlled trials and data from their own prospective institutional database.
Prior Authorization Increases Use of Health Care Resources and Adverse Events, Docs Say
A majority of physicians surveyed said that prior authorization results in increased use of health care resources, and one-third said prior authorization led to a serious adverse event for a patient.
Infections Observed in Half of MM Patients Treated With Bispecific Antibodies
Infections are common among patients with relapsed/refractory multiple myeloma treated with bispecific antibodies, a study suggests.
Fat Loss Portends Worse Prognosis in ICI-Treated Metastatic Clear Cell RCC
Change in subcutaneous fat after initiation of immune checkpoint inhibitors may distinguish which patients will and will not respond to therapy.
Pfizer-BioNTech Bivalent Booster Authorized for Kids Under 5 Years
The FDA has authorized use of the bivalent Pfizer-BioNTech COVID-19 vaccine as a booster dose for children 6 months through 4 years of age.
Aspirin and Metformin Combo Linked to Higher Risk of Cancer Death
Among older patients with diabetes, metformin was associated with a reduced risk of cancer, but the combination of aspirin and metformin was associated with an increased risk of cancer death.
Immunotherapy May Increase the Risk of Treatment Discontinuation in SCLC
Adding immunotherapy to chemotherapy may increase the risk of toxicity and likelihood of treatment discontinuation in patients with SCLC, a meta-analysis suggests.
Axillary Lymphadenopathy Resolves at Mean 102 Days After COVID-19 Booster
The mean time to resolution of axillary lymphadenopathy after a COVID-19 vaccine booster is 102 days, according to a study.
Anti-GPRC5D CAR-T Therapy Elicits Responses After Anti-BCMA CAR Failure
Anti-GPRC5D CAR T-cell therapy can produce responses in patients with relapsed or refractory multiple myeloma, a phase 2 trial suggests.
Radical Cystectomy Increases Risks for Thromboembolic Events
Patients undergoing radical cystectomy for bladder cancer have an increased risk of thromboembolic events that may persist for months after surgery.
Partial Cytoreductive Nephrectomy Still Offers Survival Edge in Metastatic RCC
Partial vs radical cytoreductive nephrectomy for clear cell metastatic renal cell carcinoma was associated with a 54% decreased risk for other-cause mortality.
Personalized ctDNA Monitoring Can Predict Outcomes in Advanced Melanoma
Personalized ctDNA monitoring can predict outcomes during and after treatment in patients with advanced melanoma, a study suggests.
Cost of Radical Cystectomy Higher in the West Than in Other US Regions
Total hospital costs related to radical cystectomy are higher in the West than in all other regions of the United States, a study suggests.
Ramucirumab Does Not Improve Upon Chemotherapy in Advanced Pancreatic Cancer
Adding ramucirumab to first-line chemotherapy does not improve outcomes in patients with advanced pancreatic ductal adenocarcinoma, a study suggests.
Low Prostate Cancer-Specific Mortality Seen for Men With Localized Disease
New research suggests that men with localized prostate cancer have low prostate cancer-specific mortality at 15 years, regardless of the treatment they receive.
Benefits Persist for Lenvatinib Plus Pembrolizumab in Renal Cell Cancer
Lenvatinib plus pembrolizumab improved outcomes vs sunitinib in patients with advanced renal cell carcinoma.
Coalition for Trust in Health & Science Launched to Curb “Infodemic”
Fifty US organizations have launched the Coalition for Trust in Health & Science to curb health and science misinformation and disinformation.
10-Year Data Support Use of Adjuvant Paclitaxel-Trastuzumab in HER2+ Breast Cancer
Updated results support the use of adjuvant paclitaxel and trastuzumab in small, node-negative, HER2-positive breast cancer, according to researchers.
Upfront Atezolizumab Poses Lower Risk of Hyperprogression in NSCLC
The risk of hyperprogression is lower when atezolizumab is given upfront to patients with advanced non-small cell lung cancer, a study suggests.
Pembrolizumab Demonstrates Activity in Diffuse Malignant Peritoneal Mesothelioma
Pembrolizumab can produce responses in patients with diffuse malignant peritoneal mesothelioma, according to a retrospective study.
RCC Stratification System May Need to Be Refined, Data Suggest
Investigators concluded that pN1 RCC could be stratified into pN1 and pN2, with pN2 conferring a poor prognosis comparable to that of non-metastatic stage IV pN0 disease.
Aortic Calcification Ups Risk for Acute Kidney Injury After Radical Cystectomy
Aortic calcification may lead to arterial degradation that increases the risk for acute kidney injury, according to investigators.
FDA Panel Votes on Polivy Combo for First-Line Treatment of DLBCL
An FDA panel voted in favor of approving polatuzumab vedotin in combination with R-CHP for previously untreated DLBCL.
Initiative Increased BRCA Testing in Ovarian Cancer Patients
A multipronged initiative increased germline BRCA mutation testing for patients with ovarian cancer by 31%.
Alisertib Does Not Restore Sensitivity to Fulvestrant in Endocrine-Resistant Breast Cancer
Alisertib monotherapy has shown activity in postmenopausal patients with endocrine-resistant, HER2-negative, metastatic breast cancer, but it was not able to restore sensitivity to fulvestrant in this patient population.
Short-Course RT Plus Chemo Can Decrease Distant Metastasis in High-Risk LARC
Compared with standard care, preoperative short-course RT followed by chemotherapy can decrease distant metastasis in patients with high-risk LARC.
Insurance Status Mediates Racial, Ethnic Inequities in Cervical Cancer
A larger proportion of patients with private or Medicare insurance received a diagnosis of early-stage cervical cancer.
Prostate Cancer Treatment Pluvicto Currently in Shortage
Pluvicto is currently in shortage due to challenges in meeting demand and no therapeutic equivalents being available.
Americans Experience Delays or Challenges in Getting Health Care Due to Understaffing
Nearly 75% of poll respondents who needed health care in the past 6 months experienced delays or challenges in getting that care.
ctDNA Testing in Colorectal Cancer Deemed Promising but Not Ready for Prime Time
Studies suggest that ctDNA testing has prognostic value in colorectal cancer, but more research is needed before it can be used in practice.
Osimertinib and Platinum Chemo Produces Unprecedented Results in NSCLC
A phase 2 trial suggests that frontline osimertinib and platinum-based chemotherapy is safe and effective in EGFR-mutated, advanced NSCLC.
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