Benign Prostatic Hyperplasia (BPH) Treatments
|BENIGN PROSTATIC HYPERPLASIA TREATMENTS|
|5α-REDUCTASE (5AR) INHIBITORS1|
|dutasteride||Avodart||caps||0.5mg||0.5mg once daily||• Inhibits type I (liver, skin) and II (genitourinary) 5AR • >90% suppression of baseline serum DHT|
|finasteride||Proscar||tabs||5mg||5mg once daily||• Inhibits type II (genitourinary) 5AR • 70% suppression of baseline serum DHT|
|alfuzosin||Uroxatral||extended-release tabs||10mg||10mg daily||• Swallow whole • Take after meal • Dose titration not needed|
|doxazosin||Cardura||scored tabs||1mg, 2mg, 4mg, 8mg||Initially 1mg daily; may double dose every 1–2wks; max 8mg daily|
|Cardura XL||extended-release tabs||4mg, 8mg||Initially 4mg daily; may titrate after 3–4wks; max 8mg daily||• Swallow whole • Take with breakfast|
|silodosin||Rapaflo||caps||4mg, 8mg||8mg once daily||• Take with a meal • Renal impairment (CrCl 30–50mL/min): 4mg|
|tamsulosin||Flomax||caps||0.4mg||Initially 0.4mg daily; may increase to 0.8mg daily after 2–4wks||• Swallow whole • Take ½ hr after same meal each day|
|terazosin||Hytrin||caps||1mg, 2mg, 5mg, 10mg||Initially 1mg daily; max 20mg daily||• Give at bedtime|
|COMBINATION 5AR INHIBITORS1 & α1-BLOCKERS2,3|
|1 cap once daily||• Swallow whole • Take ½ hr after same meal each day|
|tadalafil||Cialis||tabs||2.5mg, 5mg, 10mg*, 20mg*||5mg taken at approximately the same time every day||• Also indicated for erectile dysfunction + BPH: take without regard to timing of sexual activity. • Moderate renal dysfunction (CrCl 30–50mL/min): Initially 2.5mg, may increase to 5mg. • Severe renal dysfunction (CrCl <30mL/min): not recommended. • Mild or moderate hepatic impairment: use caution; severe: not recommended. • Concomitant alpha blockers: not recommended. • Concomitant potent CYP3A4 inhibitors: max 2.5mg.|
* These strengths are not indicated for use in BPH.
15AR inhibitors lower prostate specific antigen (PSA) levels in a predictable fashion, adjust interpretation of PSA levels accordingly.
2α1-blockers may cause orthostatic hypotension; titrate dose slowly. When therapy has been interrupted for several days or longer, patients should be retitrated from the initial dose.
3Although rare, priapism and subsequent permanent impotence has been associated with the use of α1-blockers and patients should be fully informed of this risk.
Not an inclusive list of medications. Please see drug monograph at the CTA Drug Database and/or contact company for full drug labeling.
This article originally appeared on MPR