| DIABETES TREATMENTS | |||||
|---|---|---|---|---|---|
| Generic | Brand | Strength | Form | Usual Maintenance Range |
Usual Max Dose |
| ALPHA-GLUCOSIDASE INHIBITOR | |||||
| acarbose | Precose | 25mg, 50mg, 100mg | tabs | 50−100mg three times daily |
≤60kg: 150mg/day in 3 divided doses >60kg: 300mg/day in 3 divided doses |
| miglitol | Glyset | 25mg, 50mg, 100mg | tabs | 50mg three times daily | 300mg/day in 3 divided doses |
| AMYLIN ANALOGUE/AMYLINOMIMETIC | |||||
| pramlintide | Symlin | 0.1mg/mL | inj soln | Type 1: 30−60mcg Type 2: 60−120mcg |
— |
| BIGUANIDE | |||||
| metformin | Fortamet | 500mg, 1000mg | ext‑rel tabs | — | 2.5g/day |
| Glucophage | 500mg, 850mg, 1000mg | tabs | — | 2.55g/day in 2–3 divided doses | |
| Glucophage XR | 500mg, 750mg | ext‑rel tabs | — | 2g/day in 1–2 divided doses | |
| Glumetza | 500mg, 1000mg | ext‑rel tabs | — | 2g/day | |
| Riomet | 500mg/5mL | oral soln | — | 2.55g/day (25.5mL) in 2–3 divided doses | |
| BILE ACID SEQUESTRANT | |||||
| colesevelam | Welchol | 625mg | tabs | 6 tabs once daily or 3 tabs twice daily | 4.5g/day |
| Welchol for Oral Suspension | 3.75g | pwd pkts | One 3.75g pkt once daily | ||
| DIPEPTIDYL PEPTIDASE-4 INHIBITOR | |||||
| alogliptin | Nesina | 6.25mg, 12.5mg, 25mg | tabs | 25mg once daily | — |
| linagliptin | Tradjenta | 5mg | tabs | 5mg once daily | — |
| saxagliptin | Onglyza | 2.5mg, 5mg | tabs | 2.5mg or 5mg once daily | — |
| sitagliptin | Januvia | 25mg, 50mg, 100mg | tabs | 100mg once daily | — |
| DIPEPTIDYL PEPTIDASE-4 INHIBITOR + BIGUANIDE | |||||
| alogliptin/ metformin |
Kazano | 12.5mg/500mg, 12.5mg/1000mg | tabs | — | 25mg/2000mg per day in divided doses |
| linagliptin/ metformin |
Jentadueto | 2.5mg/500mg, 2.5mg/850mg, 2.5mg/1000mg | tabs | — | 2.5mg/1000mg twice daily |
| Jentadueto XR | 2.5mg/1000mg, 5mg/1000mg | ext-rel tabs | — | 5mg/2000mg daily | |
| saxagliptin/ metformin HCl ext‑rel |
Kombiglyze XR | 5mg/500mg, 5mg/1000mg, 2.5mg/1000mg | ext-rel tabs | — | 5mg/2000mg per day |
| sitagliptin/ metformin |
Janumet | 50mg/500mg, 50mg/1000mg | tabs | — | 100mg/2000mg per day |
| Janumet XR | 50mg/500mg, 50mg/1000mg, 100mg/1000mg | ext‑rel tabs | |||
| DIPEPTIDYL PEPTIDASE-4 INHIBITOR + THIAZOLIDINEDIONE | |||||
| alogliptin/ pioglitazone |
Oseni | 12.5mg/15mg, 12.5mg/30mg, 12.5mg/45mg, 25mg/15mg, 25mg/30mg, 25mg/45mg | tabs | — | 25mg/45mg daily |
| DOPAMINE RECEPTOR AGONIST | |||||
| bromocriptine | Cycloset | 0.8mg | tabs | 1.6−4.8mg/ day |
4.8mg/day |
| |
|||||
| Generic | Brand | Strength | Form | Usual Maintenance Range |
Usual Max Dose |
| GLINIDE | |||||
| nateglinide | Starlix | 60mg, 120mg | tabs | 120mg 1−30min before meals three times daily | 360mg/day in 3 divided doses |
| repaglinide | Prandin | 0.5mg, 1mg, 2mg | tabs | 0.5−4mg within 30min of meals 2−4 times daily | 16mg/day |
| GLINIDE + BIGUANIDE | |||||
| repaglinide/ metformin |
PrandiMet | 1mg/500mg, 2mg/500mg |
tabs | — | 4mg/1000mg per meal or 10mg/2500mg per day |
| GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST | |||||
| dulaglutide | Trulicity | 0.75mg/0.5mL, 1.5mg/0.5mL | inj soln | 0.75mg−1.5mg once weekly | 1.5mg once weekly |
| exenatide | Byetta | 250mcg/mL | inj soln | 5−10mcg twice daily | 10mcg twice daily |
| exenatide ext‑rel | Bydureon | 2mg | inj susp | 2mg once every 7 days | — |
| liraglutide | Victoza | 6mg/mL | inj soln | 1.2−1.8mg/ day |
— |
| lixisenatide | Adlyxin | 50mcg/mL, 100mcg/mL | inj soln | 20mcg once daily | — |
| semaglutide | Ozempic | 2mg/1.5mL | inj soln | 0.5–1mg once weekly | 1mg once weekly |
| SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR | |||||
| canagliflozin | Invokana | 100mg, 300mg | tabs | 100−300mg once daily | 300mg once daily |
| dapagliflozin | Farxiga | 5mg, 10mg | tabs | 5−10mg once daily in AM | 10mg once daily |
| empagliflozin | Jardiance | 10mg, 25mg | tabs | 10−25mg once daily | 25mg once daily |
| ertugliflozin | Steglatro | 5mg, 15mg | tabs | 5−15mg once daily in AM | 15mg once daily |
| SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR + BIGUANIDE | |||||
| canagliflozin/ metformin HCl |
Invokamet | 50mg/500mg, 50mg/1000mg, 150mg/500mg, 150mg/1000mg | tabs | — | 300mg/2000mg per day |
| Invokamet XR | 50mg/500mg, 50mg/1000mg, 150mg/500mg, 150mg/1000mg | ext-rel tabs | |||
| dapagliflozin/ metformin HCl ext‑rel |
Xigduo XR | 5mg/500mg, 5mg/1000mg, 10mg/500mg, 10mg/1000mg | ext-rel tabs | — | 10mg/2000mg per day |
| empagliflozin/ metformin HCl |
Synjardy | 5mg/500mg, 12.5mg/500mg, 5mg/1000mg, 12.5mg/1000mg | tabs | — | 25mg/2000mg per day |
| Synjardy XR | 5mg/1000mg, 10mg/1000mg, 12.5mg/1000mg, 25mg/1000mg | ext‑rel tabs | |||
| ertugliflozin/ metformin HCl |
Segluromet | 2.5mg/500mg, 2.5mg/1000mg, 7.5mg/500mg, 7.5mg/1000mg | tabs | — | 15mg/2000mg per day |
| SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITOR + DIPEPTIDYL PEPTIDASE‑4 INHIBITOR | |||||
| dapagliflozin/ saxagliptin |
Qtern | 10mg/5mg | tabs | 10mg/5mg once daily in AM | — |
| empagliflozin/ linagliptin |
Glyxambi | 10mg/5mg, 25mg/5mg | tabs | — | 25mg/5mg once daily |
| ertugliflozin/ sitagliptin |
Steglujan | 5mg/100mg, 15mg/100mg | tabs | — | 15mg/100mg once daily |
| SULFONYLUREA | |||||
| chlorpro– pamide 1st generation |
Diabinese | 100mg, 250mg | scored tabs | 250−750mg in single or divided doses | 750mg/day in single or divided doses |
| glimepiride | Amaryl | 1mg, 2mg, 4mg | scored tabs | 1−4mg once daily | 8mg/day |
| glipizide 2nd generation |
Glucotrol | 5mg, 10mg | scored tabs | 5−15mg once daily or 5−40mg in divided doses | 15mg once daily or 40mg in divided doses |
| Glucotrol XL |
2.5mg, 5mg, 10mg | ext‑rel tabs | 5−10mg once daily | 20mg/day | |
| glyburide 2nd generation |
Diabeta | 1.25mg, 2.5mg, 5mg | scored tabs | 1.25−20mg in single or divided doses | 20mg/day in single or divided doses |
| glyburide, micronized 2nd generation |
Glynase PresTab | 1.5mg, 3mg, 6mg | scored tabs | 0.75−12mg in single or divided doses | 12mg/day in divided doses |
| SULFONYLUREA + BIGUANIDE | |||||
| glipizide/ metformin |
— | 2.5mg/250mg, 2.5mg/500mg, 5mg/500mg |
tabs | — | 20mg/2000mg per day in single or divided doses |
| glyburide/ metformin |
— | 2.5mg/500mg, 5mg/500mg |
tabs | — | 20mg/2000mg per day |
| THIAZOLIDINEDIONE | |||||
| pioglitazone | Actos | 15mg, 30mg, 45mg | tabs | 15−45mg once daily | 45mg once daily |
| rosiglitazone | Avandia | 2mg, 4mg, 8mg | tabs | 4−8mg in single or 2 divided doses | 8mg/day |
| THIAZOLIDINEDIONE + BIGUANIDE | |||||
| pioglitazone/ metformin |
ACTOplus met | 15mg/500mg, 15mg/850mg | tabs | — | 45mg/2550mg per day in divided doses |
| ACTOplus met XR | 15mg/1000mg, 30mg/1000mg | ext‑rel tabs | — | 45mg/2000mg per day | |
| rosiglitazone/ metformin |
— | 1mg/500mg, 2mg/500mg, 4mg/500mg, 2mg/1000mg, 4mg/1000mg | tabs | — | 8mg/2000mg per day in divided doses |
| THIAZOLIDINEDIONE + SULFONYLUREA | |||||
| pioglitazone/ glimepiride |
Duetact | 30mg/2mg, 30mg/4mg | tabs | — | One 30mg/4mg tab once daily |
| rosiglitazone/ glimepiride |
— | 4mg/1mg, 4mg/2mg, 4mg/4mg, 8mg/2mg, 8mg/4mg | tabs | — | 8mg/4mg per day |
| NOTES | |||||
|
Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. These products are intended for use as part of a total treatment regimen to maintain glycemic control that includes diet, regular exercise, blood glucose monitoring, and glycosylated hemoglobin monitoring. Patients should maintain regular caloric intake. Adjust dose based on clinical effect. Start at a low dose and gradually titrate upwards according to clinical effect (especially in the elderly, malnourished, debilitated, or those who have renal and/or hepatic dysfunction). (Rev. 7/2018) |
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This article originally appeared on MPR
