Specific Cancer Types

Analyses of the Oxford Vegetarian Study and EPIC-Oxford, and the Adventist cohorts with mean follow-ups ranging from 4.14 to 7.8 years, found no difference in cancer risk with a vegan diet compared with a nonvegetarian diet for colorectal, breast, gastrointestinal, respiratory tract, or urinary tract cancers.5-9 For breast cancer, an analysis of the AHS-2 found a nonsignificant trend toward a reduced cancer risk (HR, 0.78; 95% CI, 0.58-1.05; P = .09), but this trend was further shifted toward the null when adjusting for BMI (P = .25).8

The incidence of prostate cancer, however, was significantly reduced by 35% in the vegan cohort of the AHS-2 study compared with nonvegetarians (HR, 0.65; 95% CI, 0.49-0.85).10 When stratified by race, the benefit remained only for whites (HR, 0.63; 95% CI, 0.46-0.86), but was nonsignificant among blacks (HR, 0.69; 95% CI, 0.41-1.18), which may have been due to a small sample size (44 vs 15 events, respectively).

Conclusion

Adoption of a vegan diet may reduce the risk of developing cancer, but the data are inconclusive regarding specific cancer types. There are no data regarding whether the diet is an effective means of prevention among high-risk populations. A major limitation of the studies evaluating the effect of a vegan diet on cancer risk is the small sample size of vegans and the number of cancer events. There is no evidence of harm from following a vegan diet and it may be a healthy option for patients who properly plan meals. Clinicians should recommend that patients following special diets consult with a dietician to ensure the diet provides sufficient nutrition.

References

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