Osler-Weber-Rendu Disease

Preliminary Diagnosis: Osler-Weber-Rendu Disease

I. What imaging technique is first-line for this diagnosis

  • Plain radiography.

II. Describe the advantages and disadvantages of this technique for diagnosis of Osler-Weber-Rendu disease.


  • Quick and relatively inexpensive imaging modality

  • Exposes patients to minimal ionizing radiation


  • Poorly sensitive and specific in detailing and characterizing any potential hereditary hemorrhagic telangiectatic lesions

  • Does not offer exquisite visualization and evaluation of the surrounding soft tissues and osseous structures

  • Unable to guide treatment and therapy

III. What are the contraindications for the first-line imaging technique?

  • No specific contraindications to plain radiography exist. Some institutions may require consent for pregnant women.

IV. What alternative imaging techniques are available?

  • CT of the area of interest

  • Catheter angiography

V. Describe the advantages and disadvantages of the alternative techniques for diagnosis Osler-Weber-Rendu disease.

CT of the area of interest


  • Offers exquisite visualization of the surrounding soft tissues, vascular structures, and osseous structures

  • May guide treatment

  • Relatively quick imaging modality

  • Highly sensitive and specific in detecting, diagnosing, and characterizing potential lesions


  • Exposes patients to ionizing radiation.

Catheter angiography


  • Gold standard in diagnosing and treating patients with Osler-Weber-Rendu disease

  • Highly sensitive and specific in detecting and characterizing telangiectatic lesions


  • Invasive procedure and exposes patients to the risks of an invasive procedure

  • May expose patients to large amounts of ionizing radiation

VI. What are the contraindications for the alternative imaging techniques?

CT of the area of interest

  • May be contraindicated in pregnant patients

Catheter angiography

  • May be contraindicated in pregnant patients and those in a hypocoagulable state

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