In The Clinic

Volatile Organic Compounds and Esophageal Cancer: Understanding the Implications for Diagnosis and Treatment

Volatile Organic Compounds and Esophageal Cancer: Understanding the Implications for Diagnosis and Treatment

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While utilization of VOCs in the early detection of esophageal cancer has shown promise, future studies should aim at determining which VOCs would be the most specific in diagnosing GI malignancies.

Managing PD-1 Inhibitor-induced Pneumonitis

Managing PD-1 Inhibitor-induced Pneumonitis

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Recent advances in immunotherapy preceded the approval of programmed cell death 1 (PD-1) inhibitors for the treatment of a variety of cancer types.

Isabel Cunningham Holds CML Question-and-Answer Session With Jane Apperley, MD

Isabel Cunningham Holds CML Question-and-Answer Session With Jane Apperley, MD

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Isabel Cunningham, MD, advisory board member for CTA, asks Dr Apperley about how to treat patients with CML that cause specialists particular concern.

Upper Gastrointestinal Bleeding Secondary to Malignancy

Upper Gastrointestinal Bleeding Secondary to Malignancy

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Although infrequent, malignancy is a cause of upper gastrointestinal bleeding that should be included on the differential diagnosis.

In Melanoma, Adjuvant Lymph Node Field Radiotherapy Does Not Impact Survival

In Melanoma, Adjuvant Lymph Node Field Radiotherapy Does Not Impact Survival

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Researchers confirmed that for most patients with melanoma, entry to an adjuvant systemic therapy trial is a preferable first option.

Treating Pain in Patients with Cancer: Considerations When Prescribing Opioids

Treating Pain in Patients with Cancer: Considerations When Prescribing Opioids

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There are key factors to consider when determining the best treatment strategy for pain in patients with cancer.

Inferior Vena Cava Filters in Patients with Cancer

Inferior Vena Cava Filters in Patients with Cancer

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The placement of an inferior vena cava filter is understudied in patients with cancer and clear guidelines do not exist.

Identifying, Treating Upper Extremity Deep Vein Thrombosis in Patients with Cancer

Identifying, Treating Upper Extremity Deep Vein Thrombosis in Patients with Cancer

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While lower extremity DVTs are the most common, up to 10% of DVTs can occur in upper extremeties in patients with cancer.

Enoxaparin Efficacious, Feasible for Prevention of VTE in Advanced Pancreatic Cancer

Enoxaparin Efficacious, Feasible for Prevention of VTE in Advanced Pancreatic Cancer

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Recent research shows that enoxaparin effectively prevents VTE complications in advanced pancreatic cancer without decreasing efficacy of chemotherapy.

Malignant Gastric Outlet Obstruction

Malignant Gastric Outlet Obstruction

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Common gastrointestinal symptoms experienced by patients with cancer can vary widely and determining an underlying malignancy can prove difficult.

The Power of Placebo in Aromatase Inhibitor-Induced Arthralgia

The Power of Placebo in Aromatase Inhibitor-Induced Arthralgia

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Researcher found an improvement in aromatase inhibitor-associated arthralgia in both omega-3 fatty acids and placebo treatment.

Stereotactic Body Radiotherapy Using Fiducial Implants for Pancreatic Cancer

Stereotactic Body Radiotherapy Using Fiducial Implants for Pancreatic Cancer

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New treatment modalities are being developed for patients with pancreatic cancer aimed at improving efficacy as well as limiting toxicity.

ABVD, Radiotherapy vs. Stanford V in Stage 1/2 Bulky Hodgkin Lymphoma

ABVD, Radiotherapy vs. Stanford V in Stage 1/2 Bulky Hodgkin Lymphoma

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ABVD and Stanford V treatment regimens show similar efficacy in patients with Hodgkin lymphoma.

Malignant Ascites: Diagnosis and Management

Malignant Ascites: Diagnosis and Management

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Up to 10 percent of ascites diagnoses are related to cancer.

Treatment Options for Peritoneal Carcinomatosis Associated with Colorectal Cancer

Treatment Options for Peritoneal Carcinomatosis Associated with Colorectal Cancer

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As newer treatment options for peritoneal carcinomatosis are developed, more clinical data is needed to support use in patients with colorectal cancer.

Nutritional Challenges in Oncology Patients

Nutritional Challenges in Oncology Patients

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Oncology patients with malnutrition clinically do worse with respect to survival, response to treatment, and adverse events.

Carfilzomib Superior to Bortezomib for Relapsed Multiple Myeloma

Carfilzomib Superior to Bortezomib for Relapsed Multiple Myeloma

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Analysis from phase III ENDEAVOR trial showed Kyprolis and dexamethasone superior to Velcade and dexamethasone in relapsed multiple myeloma.

Anticoagulants and Gastrointestinal Cancer Detection

Anticoagulants and Gastrointestinal Cancer Detection

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The "antigocoagulation gastrointestinal stress test" could represent a previously under-recognized modality leading to early detection of GI malignancy.

Prophylactic Effect of Urea-Based Cream on Sorafenib Skin Reactions

Prophylactic Effect of Urea-Based Cream on Sorafenib Skin Reactions

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Onset of sorafenib-associated hand-foot skin reactions can be delayed by urea-based cream plus best supportive care in advanced hepatocellular carcinoma.

Obesity and Chemotherapy Dosing in Patients with Cancer

Obesity and Chemotherapy Dosing in Patients with Cancer

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Chemotherapy can be dosed based on body surface area or body weight, but some studies show up to 40% of obese patients receive lower doses.

Treating Hypercalcemia in Patients with Cancer

Treating Hypercalcemia in Patients with Cancer

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Hypercalcemia is one of the most common laboratory abnormalities in patients with cancer, and oncologists should know how to identify and treat it.

Managing Anticoagulation in Patients with Brain Tumors

Managing Anticoagulation in Patients with Brain Tumors

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Patients with brain cancer are at increased risk of deep vein thrombosis and consequently pulmonary embolism.

Cardiotoxicity Associated With Monoclonal Antibody Chemotherapy

Cardiotoxicity Associated With Monoclonal Antibody Chemotherapy

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Surveillance for cardiotoxicity must be a part of treating patients with monoclonal antibodies.

Nonbacterial Thrombotic Endocarditis and Malignancy

Nonbacterial Thrombotic Endocarditis and Malignancy

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Underlying malignancy is a potential cause of nonbacterial thrombotic endocarditis, understanding symptoms and treatment options is important.

MDRO Infections in Patients with Neutropenic Fever

MDRO Infections in Patients with Neutropenic Fever

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Fever is a common symptom for patients with cancer who have neutropenia and it is often difficult to determine if they are in infectious in etiology.

Inpatient Versus Outpatient Cancer Therapy: Costs, Benefits, and Risks

Inpatient Versus Outpatient Cancer Therapy: Costs, Benefits, and Risks

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Oncology clinicians must balance the cost, benefit, and risk when comparing inpatient versus outpatient care for patients.

Iniparib May Be Effective as Salvage Therapy for Metastatic Triple-Negative Breast ​Cancer

Iniparib May Be Effective as Salvage Therapy for Metastatic Triple-Negative Breast ​Cancer

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Despite promising results, iniparib was found to be ineffective as first-line therapy for patients with metastatic triple-negative breast cancer.

Rolapitant Proves Effective for the Prevention of Chemotherapy-Induced Nausea and Vomiting

Rolapitant Proves Effective for the Prevention of Chemotherapy-Induced Nausea and Vomiting

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Rolapitant in combination with granisetron and dexamethasone is effective in preventing chemotherapy-induced nausea and vomiting.

Aprepitant for the Prevention of Chemotherapy-Induced Nausea, Vomiting in Multiple Myeloma

Aprepitant for the Prevention of Chemotherapy-Induced Nausea, Vomiting in Multiple Myeloma

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New regimen resulted in significantly less chemotherapy-induced nausea and vomiting in multiple myeloma patients.

Malignancies in Patients With Neurofibromatosis Type 1 (NF-1)

Malignancies in Patients With Neurofibromatosis Type 1 (NF-1)

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Patients with NF-1 are up to 4 times more likely to get both benign and malignant neoplasms, in the muscles, skin, and gastrointestinal tract.

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