Headlines

General Oncology Tumor Hypoxia and Papaverine: A New Use for an Old Drug?

Tumor Hypoxia and Papaverine: A New Use for an Old Drug?

Papaverine was found to sensitize tumors in a way that could potentially improve their response to radiation therapy in patients with certain tumor types.

General Oncology Gene-Delivery Method Generates Immune Checkpoint Antibodies In Vivo

Gene-Delivery Method Generates Immune Checkpoint Antibodies In Vivo

In mice, DNA-encoded plasmids generated sufficient in vivo expression of immune checkpoint antibody CTLA-4; DMabs may one day rival traditional mAbs.

Hematologic Cancers New Definition for Plasma Cell Leukemia Proposed

New Definition for Plasma Cell Leukemia Proposed

Researchers proposed lowering the circulating plasma cell threshold from 20% to 5% for plasma cell leukemia, thus creating a new definition for diagnosis.

Chronic Myeloid Leukemia Targeting Functional Noncoding RNAs in CML With Cas9

Targeting Functional Noncoding RNAs in CML With Cas9

A new screening approach identifies more than 200 lncRNAs essential for survival in CML cells, suggesting lncRNAs could be good prospective targets for therapies.

General Oncology Preexisting Immunity to CRISPR-Cas9: A Problem for Gene Editing in Cancer?

Preexisting Immunity to CRISPR-Cas9: A Problem for Gene Editing in Cancer?

Evidence is building to show that most people have preexisting immunity to CRISPR-based therapies. In cancer, however, it's unclear how much that matters.

General Oncology Cancer Recurrence: Tackling a Valid Survivor Fear

Cancer Recurrence: Tackling a Valid Survivor Fear

Researchers are learning that roughly half of survivors live with a moderate to high degree of fear of recurrence, and teaching techniques to better cope with uncertainty is one way to help.

Breast Cancer Lower-Dose, Shorter-Duration Chemotherapy Regimens: Is This a Trend?

Lower-Dose, Shorter-Duration Chemotherapy Regimens: Is This a Trend?

Lower doses and shorter treatment regimens have the potential to reduce both physical and financial toxicity for patients.

Lymphoma CD19 CAR T-Cell Therapies: "Expect an Evolution"

CD19 CAR T-Cell Therapies: "Expect an Evolution"

"CD19 CAR therapy has paved the way for a new field of medicine based on the genetic instruction of T-cell responses," according to Dr Michel Sadelin.

Multiple Myeloma Selinexor Trials Move Nuclear Suppressor Protein-Export Inhibition Closer to the Clinic for Multiple Myeloma

Selinexor Trials Move Nuclear Suppressor Protein-Export Inhibition Closer to the Clinic for Multiple Myeloma

XPO1 inhibition restores the ability of intranuclear tumor suppressor genes to disrupt oncoproteins; it is emerging as a promising new investigational strategy in MM.

Prostate Cancer Does Epigenetic Therapy With Panobinostat Reduce CRPC Bicalutamide Resistance?

Does Epigenetic Therapy With Panobinostat Reduce CRPC Bicalutamide Resistance?

Panobinostat plus bicalutamide increased radiographic progression-free survival in patients with CRPC resistant to second-line antiandrogen therapy.

Skin Cancer Nivolumab Monotherapy Provides Long-Term Benefit Advanced Melanoma

Nivolumab Monotherapy Provides Long-Term Benefit Advanced Melanoma

Dacarbazine, although once a staple of melanoma therapy, essentially has no current role in the treatment of any type or stage of melanoma.

Chronic Myeloid Leukemia EUTOS Long-Term Survival Score Outperforms Sokal in TKI-Treated CML

EUTOS Long-Term Survival Score Outperforms Sokal in TKI-Treated CML

EUTOS long-term survival score better predicted prognosis for those with chronic myeloid leukemia who had been treated with TKIs—especially among elderly patients.

Multiple Myeloma Daratumumab Combination: New Standard of Care in Transplant-Ineligible Multiple Myeloma

Daratumumab Combination: New Standard of Care in Transplant-Ineligible Multiple Myeloma

The findings may support the triplet regimen as a new standard of care for these patients, according to Dr Facon.

Renal Cell Carcinoma The Changing Treatment Landscape for Advanced Renal Cell Carcinoma

The Changing Treatment Landscape for Advanced Renal Cell Carcinoma

Interferon or high-dose interleukin-2 were the only available options for the treatment of metastatic RCC until 2005.

Multiple Myeloma Early-Access Daratumumab Trial Supports Safety in Relapsed, Refractory MM

Early-Access Daratumumab Trial Supports Safety in Relapsed, Refractory MM

Researchers also used the trial to collect more information on safety, patient‐reported outcomes, and a specific premedication treatment protocol.

Prostate Cancer Men With Prostate Cancer Willing to Accept Worse Survival Odds to Improve QoL

Men With Prostate Cancer Willing to Accept Worse Survival Odds to Improve QoL

Trade-offs should be carefully considered, as data have indicated that many QoL factors eventually even out.

General Oncology Gender-Based Differences in Chemotherapy: Efficacy and Safety

Gender-Based Differences in Chemotherapy: Efficacy and Safety

Women and men were found to react differently to treatment with chemotherapy, although gender-based survival differences were not observed.

Breast Cancer Liquid Biopsy as a Surveillance Tool for Breast Cancer Follow-Up

Liquid Biopsy as a Surveillance Tool for Breast Cancer Follow-Up

High-risk early breast cancer patients with circulating tumor cells 2 years after chemotherapy had greater risk of recurrence. Possible interventions are needed.

General Oncology Treatment-Related Hyperprogression: Concerns Continue to Mount

Treatment-Related Hyperprogression: Concerns Continue to Mount

Evidence is growing to support the idea that immune checkpoint inhibitors can speed up tumor growth, although the exact mechanism of how this occurs is still unclear.

Breast Cancer Conditional 10-Year Breast Cancer Recurrence Rates Decline Regardless of Subtype

Conditional 10-Year Breast Cancer Recurrence Rates Decline Regardless of Subtype

Among 4 specific breast cancer stages, T2N1 cancers showed the highest risk for local recurrence, regional recurrence, and distant metastases within 10 years from diagnosis.

Lung Cancer Trials, Collaboration Might Help Reduce Survival Disparities Between Community, Academic Cancer Centers

Trials, Collaboration Might Help Reduce Survival Disparities Between Community, Academic Cancer Centers

Better collaboration between community and academic cancer centers could benefit patients.

Lymphoma New Algorithm Improves Outcome Prediction for Diffuse Large B-Cell Lymphoma

New Algorithm Improves Outcome Prediction for Diffuse Large B-Cell Lymphoma

The model was developed using machine learning techniques and programmed with data from a Danish cancer registry.

General Oncology Moving Targets: Off-Label Prescribing of Targeted Therapies

Moving Targets: Off-Label Prescribing of Targeted Therapies

By way of the TAPUR study, researchers are attempting to evaluate the activity of targeted therapies when they are used in an off-label setting.

Chronic Myeloid Leukemia 2-Year TKI Consolidation Allowed for TKI Cessation in Select Patients With CML

2-Year TKI Consolidation Allowed for TKI Cessation in Select Patients With CML

The majority of patients studied who stopped TKI therapy remained treatment-free at 3 years.

Skin Cancer Encorafenib Plus Binimetinib Offers a New Option for MEK+BRAF Inhibition

Encorafenib Plus Binimetinib Offers a New Option for MEK+BRAF Inhibition

In the immunotherapy era, the optimal setting and sequencing of BRAF+MEK inhibition remains unresolved.

Brain Cancer Proteomics Study Reveals New Medulloblastoma Subtypes and Potential Novel Treatment Targets

Proteomics Study Reveals New Medulloblastoma Subtypes and Potential Novel Treatment Targets

Genomic and proteomic studies of medulloblastoma samples helped researchers characterize new cancer subtypes and targets.

General Oncology The Patient Behind the EHR: Oncologists Only See Half the Picture

The Patient Behind the EHR: Oncologists Only See Half the Picture

Dr Vorobiof discusses the important patient factors that can be missed via standard data collection methods for those with cancer.

Renal Cell Carcinoma Microwave Ablation for Early-Stage Renal Tumors

Microwave Ablation for Early-Stage Renal Tumors

Image-guided microwave ablation of early-stage renal tumors shows promise but a new retrospective study from the Mayo Clinic found some cases of major bleeding.

Lung Cancer Checkpoint Inhibitor Pneumonitis in NSCLC

Checkpoint Inhibitor Pneumonitis in NSCLC

Immune checkpoint inhibitor pneumonitis is a potentially serious complication that may occur more in patients with lung cancer than previously suspected.

Chronic Myeloid Leukemia Imatinib Determined the Most Cost-Effective Frontline TKI for Chronic Myeloid Leukemia

Imatinib Determined the Most Cost-Effective Frontline TKI for Chronic Myeloid Leukemia

Cost-effectiveness of TKIs for CML treatment is a complex topic that requires consideration of multiple factors — not just apparent costs to payers.

Lymphoma Tackling EBV-Associated Lymphoma: Early Research Finds Overall Survival Benefit After Donor Transplants

Tackling EBV-Associated Lymphoma: Early Research Finds Overall Survival Benefit After Donor Transplants

Use of experimental T cells that target Epstein-Barr virus proteins in relapsed or refractory lymphoma may improve overall survival.

General Oncology Guideline Updates on Quality Palliative Care

Guideline Updates on Quality Palliative Care

A draft guideline from the National Consensus Project for Quality Palliative Care describes best practices for caring for individuals who are seriously ill.

Prostate Cancer Prognostic Model for Survival in Metastatic Prostate Cancer

Prognostic Model for Survival in Metastatic Prostate Cancer

Utilizing data from the PREVAIL dataset, researchers developed mathematical models that can provide prognostic information for men being treated with enzalutamide for chemotherapy-naïve metastatic castration-resistant prostate cancer.

Prostate Cancer Anticarcinogenic Activity of Fish Oil Explored in Study

Anticarcinogenic Activity of Fish Oil Explored in Study

Omega-3 fatty acids found in fish oil act through a host receptor, GPR120, to confer anti-prostate cancer effects. Additional studies are underway.

Breast Cancer Second Opinion from Cancer Center Yielded Valuable Information for Breast Cancer Management

Second Opinion from Cancer Center Yielded Valuable Information for Breast Cancer Management

A change in diagnosis was often the result of review by a multidisciplinary tumor board at the NCI-designated cancer center.

Multiple Myeloma Risk of Secondary Primary Malignancy Does Not Outweigh Benefit of Novel Agents for Multiple Myeloma

Risk of Secondary Primary Malignancy Does Not Outweigh Benefit of Novel Agents for Multiple Myeloma

A small study identified risk factors for SPM, but survival benefits of treatment were still determined to outweigh risk.

Lymphoma Younger Women May Have Better Chance at Ovarian Function Recovery After Treatment for Hodgkin Lymphoma

Younger Women May Have Better Chance at Ovarian Function Recovery After Treatment for Hodgkin Lymphoma

Women aged 35 years or older diagnosed with Hodgkin lymphoma should discuss fertility preservation prior to treatment.

Renal Cell Carcinoma High Distress in Patients With Renal Cell Carcinoma, Call for Better Psychosocial Screening

High Distress in Patients With Renal Cell Carcinoma, Call for Better Psychosocial Screening

A high prevalence of patients with renal cell carcinoma reported distress, highlighting the need for better psychosocial screening of patients.

Breast Cancer The Immune Landscape in Metastatic Breast Cancer Is "More Inert"

The Immune Landscape in Metastatic Breast Cancer Is "More Inert"

Researchers compared the immune microenvironments of primary tumors with those at sites of metastases.

General Oncology Who Determines What 'Value' Looks Like in Value-Based Cancer Care?

Who Determines What 'Value' Looks Like in Value-Based Cancer Care?

Evaluation of patient-reported outcomes (PROs) is an important component of measuring quality in cancer care.

General Oncology Reclassification of Variants of Uncertain Significance: A Q&A With Theodora Ross MD, PhD

Reclassification of Variants of Uncertain Significance: A Q&A With Theodora Ross MD, PhD

Dr Ross described how genomic reports may need to be updated to account for new insights into a variant's role in cancer.

General Oncology Prisoner or Patient? Challenges of Cancer Care in the Incarcerated Population

Prisoner or Patient? Challenges of Cancer Care in the Incarcerated Population

This in-depth review examines the inherent challenges of providing cancer care for incarcerated patients.

General Oncology Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection

Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection

A ctDNA testing method has the capability to predict cancer recurrence, which could help guide therapy selections and uncover new drug development opportunities.

Prostate Cancer Apalutamide Does Not Diminish Quality of Life in Nonmetastatic Castration-Resistant Prostate Cancer

Apalutamide Does Not Diminish Quality of Life in Nonmetastatic Castration-Resistant Prostate Cancer

Findings from the SPARTAN trial show that HRQoL is not diminished by adding apalutamide to androgen deprivation therapy in men with asymptomatic, nonmetastatic CRPC.

Lymphoma Are Next-Gen Antibody-Drug Conjugates a Path Forward for Non-Hodgkin Lymphoma and Myeloma?

Are Next-Gen Antibody-Drug Conjugates a Path Forward for Non-Hodgkin Lymphoma and Myeloma?

The Leukemia & Lymphoma Society partnered with Sutro Biopharma to test the safety of the investigational CD74-targeting antibody-drug conjugate STRO-001 for 2 blood cancers.

Chronic Myeloid Leukemia Ponatinib Tops Bosutinib for Third-Line Treatment of CML in a Comparative Analysis

Ponatinib Tops Bosutinib for Third-Line Treatment of CML in a Comparative Analysis

A matching-adjusted indirect comparison concluded that ponatinib offers better disease control compared with bosutinib in certain patients.

Head and Neck Cancer As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination

As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination

Oropharyngeal cancers have become the most common HPV-associated malignancies in the US, where the rate of vaccination against HPV lags compared with other countries.

Gastrointestinal Cancers Bowel Preparation for Colorectal Cancer Screening: Improving Outcomes

Bowel Preparation for Colorectal Cancer Screening: Improving Outcomes

Stool burden can be a particularly challenging aspect of colonoscopies, making potentially cancerous lesions easier to miss.

Multiple Myeloma Tool for Assessing Frailty Predicts Survival in Newly Diagnosed Multiple Myeloma

Tool for Assessing Frailty Predicts Survival in Newly Diagnosed Multiple Myeloma

A patient's frailty has been determined to be associated with a higher likelihood of developing toxicities, a poor therapeutic response, and decreased survival.

General Oncology Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?

Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?

In clinical practice, most physicians and nurse practitioners do not feel comfortable enough with their medical knowledge of cannabis to offer it to patients.

Hematologic Cancers Pleural Effusions More Common Than Previously Thought in Dasatinib-Treated Leukemias

Pleural Effusions More Common Than Previously Thought in Dasatinib-Treated Leukemias

With newer treatments, alternatives to dasatinib exist, if needed.

General Oncology Fall of Star Cancer Researcher Brings Broader Picture Into View

Fall of Star Cancer Researcher Brings Broader Picture Into View

Dr José Baselga failed to disclose his financial ties to pharmaceutical companies in top-tier journals, causing many to question whether conflicts of interest are being properly reported.

Multiple Myeloma Precision Medicine: Personalizing Treatment for Multiple Myeloma

Precision Medicine: Personalizing Treatment for Multiple Myeloma

Targeted treatment options for patients with relapsed/refractory multiple myeloma are described.

Lung Cancer A Trained Dog Smells Early-Stage Lung Cancer With a High Degree of Accuracy

A Trained Dog Smells Early-Stage Lung Cancer With a High Degree of Accuracy

Humans are used to seeing canines used as tools in forensics — their skills are often harnessed to smell out drugs or trail a criminal. Some dogs are even used to locate household pests. The use of canines to detect lung cancer from smell alone, however, is a new prospect for oncologists and their patients.

Skin Cancer Combination Immunotherapy Shown To Be Clinically Meaningful in Melanoma Metastatic to the Brain

Combination Immunotherapy Shown To Be Clinically Meaningful in Melanoma Metastatic to the Brain

Updated results show prolonged responses to brain metastases.

Renal Cell Carcinoma The Identification of a Potential Early Plasma Biomarker for Kidney Cancer

The Identification of a Potential Early Plasma Biomarker for Kidney Cancer

Researchers found that doubling in KIM-1 plasma concentrations was associated with an increased risk of developing RCC and poorer survival.

Lung Cancer Despite Promising Trial Results, Skeptics Raise Red Flags About Anlotinib's Efficacy in Heavily Treated NSCLC

Despite Promising Trial Results, Skeptics Raise Red Flags About Anlotinib's Efficacy in Heavily Treated NSCLC

The VEGFR/EGFR inhibitor anlotinib prolonged PFS and OS in Chinese patients with NSCLC, but additional studies are needed to determine its benefit in other populations.

Breast Cancer Talazoparib Found to Confer a Survival Advantage in BRCA1/2-Positive Breast Cancer

Talazoparib Found to Confer a Survival Advantage in BRCA1/2-Positive Breast Cancer

Oral treatment with talazoparib improved progression-free survival and some quality of life measures compared with standard chemotherapy.

Breast Cancer BRCA1/Shieldin Double Mutations May Signal Resistance to PARP Inhibitors

BRCA1/Shieldin Double Mutations May Signal Resistance to PARP Inhibitors

Double mutants may predict resistance to PARP inhibitors and could also indicate sensitivity to alternative treatments.

Lung Cancer "Impressive" CNS Responses With Osimertinib Compared With Standard EGFR-TKIs in Patients With CNS Metastases at Baseline

"Impressive" CNS Responses With Osimertinib Compared With Standard EGFR-TKIs in Patients With CNS Metastases at Baseline

A preplanned exploratory analysis in a subset of patients from the phase 3 FLAURA study with CNS metastases at baseline shows "impressive" clinical activity in the CNS.

Prostate Cancer Genetic Counseling Recommended for Advanced Prostate Cancer

Genetic Counseling Recommended for Advanced Prostate Cancer

A new white paper emphasizes the benefits of germline testing.

General Oncology Cancer Chemotherapeutics in Rheumatoid Arthritis: A Complex Connection

Cancer Chemotherapeutics in Rheumatoid Arthritis: A Complex Connection

Research is still needed to explore the association between cancer chemotherapeutics and rheumatoid arthritis.

Skin Cancer Predicting Response to Immunotherapy in Late-Stage Melanoma

Predicting Response to Immunotherapy in Late-Stage Melanoma

A new model has the potential to identify patients with melanoma who could benefit from treatment with checkpoint inhibitors.

General Oncology Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

More than 90 medical societies have called on the US government to reverse a policy allowing step therapy under Medicare Advantage.

Chronic Myeloid Leukemia Progressive Telomere Shortening: An Epigenetic Biomarker of Chronic Myeloid Leukemia

Progressive Telomere Shortening: An Epigenetic Biomarker of Chronic Myeloid Leukemia

Progressive telomere shortening during successive cell divisions is thought to contribute to phase transition in chronic myeloid leukemia.

Breast Cancer Identifying Gene Variants Involved in Radiotherapy Toxicity Risk: A Q&A With Benjamin Smith, MD

Identifying Gene Variants Involved in Radiotherapy Toxicity Risk: A Q&A With Benjamin Smith, MD

Genomics could guide the decision about whether a patient should undergo implant reconstruction or autologous tissue-based reconstruction.

General Oncology FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

There is a push to create innovative adaptive trial designs that include more patients and, subsequently, more generalizable data.

Breast Cancer Surgeon Attitudes May Influence Genetic Testing for Patients With Breast Cancer

Surgeon Attitudes May Influence Genetic Testing for Patients With Breast Cancer

The likelihood of a patient with breast cancer receiving genetic analysis more than doubled if she went to a surgeon with a high propensity for ordering such tests.

Lymphoma Liquid Biopsy May Predict Response to Therapy in Diffuse Large B-Cell Lymphoma

Liquid Biopsy May Predict Response to Therapy in Diffuse Large B-Cell Lymphoma

Circulating tumor DNA levels measured as early as 3 weeks post-therapy may provide clues about long-term outcomes in this lymphoma subtype.

Renal Cell Carcinoma Robotic Partial Nephrectomy Compared With Open, Laparoscopic Partial Nephrectomy

Robotic Partial Nephrectomy Compared With Open, Laparoscopic Partial Nephrectomy

A meta-analysis compared outcomes between the use of partial nephrectomy using a robotic surgical approach and open or laparoscopic partial nephrectomy.

Skin Cancer Exploring the Role of Immunotherapy in Melanoma Brain Metastases

Exploring the Role of Immunotherapy in Melanoma Brain Metastases

Although checkpoint inhibitors are active against melanoma-linked brain metastases, researchers are interested in exploring combination approaches.

Renal Cell Carcinoma Clues from DNA Repair Mechanisms Could Drive Novel Therapeutic Strategies

Clues from DNA Repair Mechanisms Could Drive Novel Therapeutic Strategies

Metabolites from the Krebs cycle were found to suppress the DNA-repair pathway required for the preservation of genomic integrity.

Lung Cancer Researchers Use Artificial Intelligence to Predict Patient Survival from Pathology Images in Lung Cancer

Researchers Use Artificial Intelligence to Predict Patient Survival from Pathology Images in Lung Cancer

Artificial intelligence techniques are being employed to build complex new multivariate prognostic models for patients with lung cancer and other malignancies.

Lymphoma Obinutuzumab in Follicular Lymphoma

Obinutuzumab in Follicular Lymphoma

Many patients with follicular lymphoma will be asymptomatic and present with variable cervical, axillary, and inguinal adenopathy.

Breast Cancer High BMI Linked With Lower Breast Cancer Risk in Premenopausal Women

High BMI Linked With Lower Breast Cancer Risk in Premenopausal Women

Having a high body mass index reduces the risk for developing breast cancer before menopause, but more research is needed to understand the biological mechanism.

General Oncology Bispecific Antibodies in Cancer

Bispecific Antibodies in Cancer

Interest in these bioengineered antibodies has been rekindled by the striking success seen in the treatment of some cancers with immunotherapies.

Multiple Myeloma Selinexor and Multiple Myeloma

Selinexor and Multiple Myeloma

Early preclinical and clinical data have shown that selinexor has broad activity against multiple hematologic malignancies and notable antimyeloma activity.

General Oncology Depression as a Side Effect: Exploring a Link Between Certain Cancer Treatments and Mental Health

Depression as a Side Effect: Exploring a Link Between Certain Cancer Treatments and Mental Health

Researchers are promoting physician and patient awareness about the potential tie between depression and certain therapies.

Skin Cancer Tapping Social Media for Skin Cancer Prevention: What You Can Do

Tapping Social Media for Skin Cancer Prevention: What You Can Do

Any images and personal stories that remind people about skin cancer, what to look for, even scars after surgery, really help save lives.

Lung Cancer Re-treatment With Checkpoint Inhibitors in Some Patients With NSCLC May Be Feasible

Re-treatment With Checkpoint Inhibitors in Some Patients With NSCLC May Be Feasible

Even after an adverse event due to treatment with a checkpoint inhibitor, some patients may benefit from re-treatment with drugs from this class.

Prostate Cancer IL-23 Drives Castration-Resistant Prostate Cancer

IL-23 Drives Castration-Resistant Prostate Cancer

A growing body of evidence points to infiltrating myeloid-derived suppressor cells as key players in tumor progression and acquired treatment resistance.

Gastrointestinal Cancers Aspirin and Colorectal Cancer

Aspirin and Colorectal Cancer

Studies attempting to link ASA to a reduction in the risk of CRC have had mixed results.

General Oncology Study Reveals Scope of Genomic Variation Within Cancer Cell Lines

Study Reveals Scope of Genomic Variation Within Cancer Cell Lines

Tumor cell lines derived from single cells and curated at different reference labs have quietly evolved in vitro, accumulating distinct genomic aberrations.

Pancreatic Cancer BRCA Status Could Inform Pancreatic Cancer Management

BRCA Status Could Inform Pancreatic Cancer Management

The development of BRCA-targeted therapies might offer the best opportunities to bring pancreatic cancer into the precision-oncology era.

Lymphoma Novel Approaches for the Treatment of Primary Central Nervous System Lymphoma

Novel Approaches for the Treatment of Primary Central Nervous System Lymphoma

A review published in Blood highlights new approaches that are being investigated to treat PCNSL based on the mutational landscape and signaling pathways that are extant in the disease.

Chronic Myeloid Leukemia The Real-World Role for Second-Line Ponatinib in CML Is Still Evolving

The Real-World Role for Second-Line Ponatinib in CML Is Still Evolving

Perspectives differ on whether ponatinib is a niche drug that should be reserved for younger patients.

General Oncology Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

Approximately half of patients with advanced cancer who are enrolled in phase 1 clinical trials do not know the ultimate goal of the study.

General Oncology Pancreatic Cancer and New-Onset Diabetes

Pancreatic Cancer and New-Onset Diabetes

New-onset adult diabetes mellitus appears to be both a risk factor for and a sequelae of pancreatic cancer.

Gastrointestinal Cancers Vitamin D and Colorectal Cancer

Vitamin D and Colorectal Cancer

The vitamin D response element plays a direct role in regulating gene expression, a potential mechanism to explain how vitamin D is involved with malignancy.

Renal Cell Carcinoma Lower Costs of Pazopanib for Advanced RCC May Influence Drug Choice

Lower Costs of Pazopanib for Advanced RCC May Influence Drug Choice

Any new study of pazopanib or sunitinib must be placed in perspective of the changing treatment landscape and the market entrance of new immunotherapies.

Hematologic Cancers Using Autologous Tumor-Infiltrating Lymphocytes to Mediate Tumor Regression: Promising Outcomes in Experimental Research

Using Autologous Tumor-Infiltrating Lymphocytes to Mediate Tumor Regression: Promising Outcomes in Experimental Research

Experimental research may provide a blue print for the treatment of many types of cancer.

General Oncology Do Men Benefit More From Immune Checkpoint Inhibition?

Do Men Benefit More From Immune Checkpoint Inhibition?

A meta-analysis of 20 randomized clinical trials found that men may infer a greater benefit from immune checkpoint inhibition.

Prostate Cancer Gene Variant May Affect Response to Abiraterone in Certain Men with Prostate Cancer

Gene Variant May Affect Response to Abiraterone in Certain Men with Prostate Cancer

The breakdown of the medication abiraterone, which can be accelerated by the presence of a specific gene variant, produces drug metabolites that are suspected to play a role in the progression of prostate cancer to castration-resistant forms of disease.

Hematologic Cancers Janus Kinase Inhibitors for the Treatment of Myelofibrosis

Janus Kinase Inhibitors for the Treatment of Myelofibrosis

The identification of driver mutations in myelofibrosis has helped cement understanding of the pathophysiology of the disease and has kick-started the development of targeted therapies.

Lung Cancer The International Association for the Study of Lung Cancer Publishes Liquid Biopsy Recommendations

The International Association for the Study of Lung Cancer Publishes Liquid Biopsy Recommendations

The IASLC released guidance on the use of biopsies for the detection of EGFR and other tumor mutations in patients with NSCLC.

Chronic Myeloid Leukemia Research Indicates Imatinib Is Effective in Pediatric Patients With Chronic Phase CML

Research Indicates Imatinib Is Effective in Pediatric Patients With Chronic Phase CML

A large, long-term study found a 97% event-free survival rate at 18 months.

Lung Cancer Research Advances for Mutant KRAS-Driven Lung Adenocarcinoma

Research Advances for Mutant KRAS-Driven Lung Adenocarcinoma

Two recent studies have found that signaling from other ERBB family members is necessary for survival and proliferation in KRAS-driven tumors, and that afatinib and neratinib produce an antitumor response.

Multiple Myeloma Considerations for Relapsed Myeloma Should Match Patient, Disease, and Therapy

Considerations for Relapsed Myeloma Should Match Patient, Disease, and Therapy

Selecting therapies for patients with multiple myeloma is challenging because the disease is inherently heterogeneous.

General Oncology Triclosan and Cancer Risk: Is There a Link?

Triclosan and Cancer Risk: Is There a Link?

Some studies suggest triclosan could have oncogenic properties, but more research is needed to confirm a causal link.

Skin Cancer Next-Generation Sequencing Adds Value by Detecting More Mutations Than Polymerase Chain Reaction in Melanoma

Next-Generation Sequencing Adds Value by Detecting More Mutations Than Polymerase Chain Reaction in Melanoma

Since next-generation sequencing reflex testing has been implemented at Case Western Reserve University School of Medicine, several cases of potentially actionable mutations have been identified that would not have been caught by PCR alone.

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