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Chronic Myeloid Leukemia Pediatric CML: Life-Long Considerations With TKI Therapy

Pediatric CML: Life-Long Considerations With TKI Therapy

Because most patients with CML are adults, there are no established treatment guidelines and many clinicians apply adult guidelines to their pediatric patients.

Lung Cancer Pembrolizumab and Chemotherapy Combination Significantly Improves PFS in NSCLC

Pembrolizumab and Chemotherapy Combination Significantly Improves PFS in NSCLC

The phase 3 study found the combination effective, regardless of tumor proportion score.

Skin Cancer Marital Status Predicts Melanoma Stage at Diagnosis—But Why?

Marital Status Predicts Melanoma Stage at Diagnosis—But Why?

Married people are more likely than unmarried, divorced, or widowed patients to be diagnosed with skin cancer at early, more readily-treatable stages of disease.

General Oncology Clonally Transmissible Cancers in Nature

Clonally Transmissible Cancers in Nature

While a recent discovery of a series of communicable cancers has raised concerns, there has been no sign of readily transmittable cancer in people that could spread through a population the way the ones found in other species do.

Renal Cell Carcinoma Renal Cell Carcinoma: How Biomarkers Could Affect Drug Development

Renal Cell Carcinoma: How Biomarkers Could Affect Drug Development

An example of where biomarkers may help to select the best medication for a patient and also assist in drug development is the tyrosine kinase inhibitor (TKI) dovitinib for renal cell carcinoma (RCC).

Lung Cancer Immunotherapy for Lung Cancer: Are Combination Regimens a Path Forward?

Immunotherapy for Lung Cancer: Are Combination Regimens a Path Forward?

PD-1/PD-L1 ICI can offer remarkable benefits as first- and second-line treatments for NSCLC, but 80% of patients do not respond to immunotherapy, and many of those who do respond eventually see their cancers acquire drug resistance.

Multiple Myeloma Early Success Gives Hope for CAR T-Cell Therapy in Multiple Myeloma

Early Success Gives Hope for CAR T-Cell Therapy in Multiple Myeloma

Early trial results show that immunotherapy using chimeric antigen receptor (CAR) T-cell therapy may be effective in patients with multiple myeloma.

Renal Cell Carcinoma No Single Gene Seems to Drive Renal Cell Carcinoma Metastasis

No Single Gene Seems to Drive Renal Cell Carcinoma Metastasis

Recent research indicates that there were no significant differences in the genomic landscape of clear cell RCC primary tumors and metastases, or between the different sites of metastases.

Pediatric Cancer Does Larotrectinib Offer New Hope to Children With TRK Fusion-Positive Solid Tumors?

Does Larotrectinib Offer New Hope to Children With TRK Fusion-Positive Solid Tumors?

Because of the drug's promising safety and efficacy, the first child was treated on trial only 9 months after the first adult with a TRK fusion was treated.

Multiple Myeloma Do 9/11 Firefighters Really Have A Higher Incidence of MGUS?

Do 9/11 Firefighters Really Have A Higher Incidence of MGUS?

The firefighting profession has previously been associated with a higher risk of MGUS and myeloma compared with the general population.

Prostate Cancer Could Diet Adjustment Prevent Aggressive Prostate Cancer?

Could Diet Adjustment Prevent Aggressive Prostate Cancer?

A recent article is only the latest in a series of studies drawing attention to the importance of diet in prostate cancer development.

Breast Cancer New Methodology May Advance Precision Medicine

New Methodology May Advance Precision Medicine

A new technology is being developed by Caris Life Sciences to help improve the understanding of aberrant modulations that drive cancer.

General Oncology The Hunt for Effective Anticancer Vaccines

The Hunt for Effective Anticancer Vaccines

Researchers are hotly pursuing 2 distinct biological paths that show remarkable promise in the hunt for an effective anticancer vaccine.

Endocrine Cancer Pancreatic Cancer and the Microbiome — In the Clinic

Pancreatic Cancer and the Microbiome — In the Clinic

In the future, targets of drug development may be within the microbiome.

Skin Cancer The Benefits of Adjuvant Immunotherapy in Melanoma

The Benefits of Adjuvant Immunotherapy in Melanoma

KEYNOTE-054 may show whether some patients with resected disease can forego adjuvant therapy.

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