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LOPRESSOR HCT
Hypertension
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Drug Name:

LOPRESSOR HCT Rx

Generic Name and Formulations:
Metoprolol tartrate, hydrochlorothiazide 50mg/25mg, 100mg/25mg; scored tabs.

Company:
Validus Pharmaceuticals

Therapeutic Use:

Indications for LOPRESSOR HCT:

Hypertension.

Adult:

Titrate individual components.

Children:

Not established.

Contraindications:

Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. Sick-sinus syndrome. Severe peripheral circulatory disorders. Anuria. Sulfonamide allergy.

Boxed Warning:

Avoid abrupt discontinuation in ischemic heart disease.

Warnings/Precautions:

CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Monitor electrolytes. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Cardioselective beta-blocker + diuretic.

Interactions:

Potentiated by alcohol, CNS depressants, other antihypertensives. Bradycardia with catecholamine-depleting drugs. Metoprolol potentiated by felodipine. Increased toxicity of calcium channel blockers, lidocaine, diazoxide, digitalis, lithium. Antagonized by NSAIDs, barbiturates, rifampin. Amphotericin B, ACTH, corticosteroids increase hypokalemia risk. Adjust antidiabetic medication. May antagonize epinephrine. May interfere with parathyroid, glaucoma screening tests.

Adverse Reactions:

Fatigue, bronchospasm, dizziness, drowsiness, headache, fluid or electrolyte imbalance, bradycardia, depression, dyspnea, GI upset, blurred vision, tinnitus, earache, impotence, myalgia, cold extremities, CHF, heart block.

How Supplied:

Tabs—100


Data provided by MPR.

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