ESMO: Elderly Lung Cancer Patients Benefit from First-Line Platinum Therapies Involving 2 Agents

Share this content:
(ChemotherapyAdvisor) – Among elderly patients with advanced non-small cell lung cancer (NSCLC), first-line chemotherapy regimens that employ two cytotoxic drugs are associated with better survival times than those involving a single drug, according to a meta-analysis presented at the European Society for Medical Oncology (ESMO) annual meeting in Vienna, Austria.

The study pooled data from eight randomized, controlled clinical trials, representing a total of 2,108 elderly NSCLC patients.

“Our data indicated that doublet therapy was superior to single third-generation cytotoxic agent for elder patients with advanced NSCLC,” reported Wei-Xiang Qi of the Department of Oncology at Shanghai Jiao Tong University in Shanghai, China, and coauthors. “The optimal drug dosage and treatment schedule of platinum-based doublet (therapies) should be investigated in future prospective clinical trials. Gemcitabine-based doublet could be considered for elderly patients who were not suitable for platinum-based chemotherapy.”

Overall, 2-cytotoxic-agent therapies were associated with longer survival rates than single-agent therapies for both OR (overall survival) and progression-free survival (PFS): OR (HR 0.85 [95% CI: 0.72-1.00]; = 0.048), PFS (progression-free survival; HR 0.72 [95% CI: 0.55-0.93]; P = 0.012), 1-year survival rate (RR 1.18 [95% CI: 1.02-1.36]; P = 0.027) and ORR (overall response rate; RR 1.65 [95% CI: 1.36-1.99]; p < 0.001), the authors reported.

“Sub-group analysis also favored platinum-based doublet therapy in terms of OS, PFS/TTP, 1-year SR (survival rate) and ORR,” Dr. Qi and colleagues reported. “Though gemcitabine-based doublet significantly increased ORR compared with single agent, it did not translate into increase in survival benefits in terms of OS, PFS and 1-year survival rate.”

Two-agent regimens were associated with improved response rates and survival rates, but were also associated with higher rates of grade 3 and 4 hematologic toxicities.

Grade 3 or 4 non-hematologic adverse events overall were not significantly different between patients receiving a single-agent chemotherapy and those receiving doublet treatment, the team reported.

ESMO Abstract (#1220)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs