Tivantinib Plus Erlotinib May Improve Survival in Non-Squamous Lung Cancer

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Tivantinib plus erlotinib might improve progression-free survival in non-squamous NSCLC.
Tivantinib plus erlotinib might improve progression-free survival in non-squamous NSCLC.

Tivantinib plus erlotinib might improve progression-free survival compared with erlotinib alone in patients with non-squamous non-small cell lung cancer (NSCLC) with wild-type EGFR, a new study published online ahead of print in the journal Annals of Oncology has shown.

For the double-blind, placebo-controlled, phase 3 ATTENTION trial, researchers sought to compare the overall survival between Asian patients with non-squamous NSCLC with wild-type EGFR who received tivantinib or placebo, in combination with erlotinib.

Researchers planned to enroll 460 patients but enrollment was terminated after enrollment of only 307 patients due to a higher incidence of interstitial lung disease observed in the tivantinib group.

Results showed that median overall survival was 12.7 months in the tinvantinib group compared with 11.1 months in the placebo group (HR = 0.892; P=0.427). Researchers found that median progression-free survival was 2.9 and 2.0 months in the tivantinib and placebo groups, respectively (HR = 0.719; P=0.019).

RELATED: Platinum-Based Doublet Chemo Remains Standard of Care after First-Line Gefitinib

In regard to safety, 14 patients in the tivantinib group developed interstitial lung disease and three patients died as a result versus six patients in the placebo group who developed interstitial lung disease and no deaths. The most frequently reported adverse events in the tivantinib group were neutropenia, leukopenia, febrile neutropenia, and anemia.

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