Nab-Paclitaxel vs Solvent-Based Paclitaxel Reduces Neuropathy in Patients with NSCLC

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(ChemotherapyAdvisor) – First-line weekly nab-paclitaxel plus carboplatin was associated with statistically and clinically significant reduction in patient-reported neuropathy symptoms, neuropathic pain in the hands and feet, and hearing loss compared with solvent-based paclitaxel plus carboplatin, results of a study presented during the International Symposium on Supportive Care in Cancer, New York, NY, has found.

Mark A. Socinski, MD, of the University of Pittsburgh Medical Center, Pittsburgh, PA, and colleagues reported patient-assessed neuropathy and taxane-associated symptoms from a phase 3 trial of nab-paclitaxel plus carboplatin vs solvent-based paclitaxel plus carboplatin in patients with untreated stage IIIB/IV non–small-cell lung cancer.

Patients were randomly assigned to carboplatin AUC6 on day 1 and either nab-paclitaxel 100mg/m2 on days 1, 8, and 15 (n=521) or solvent-based paclitaxel 200mg/m2 on day 1 (n=531) every 21 days. The investigators assessed mean change from baseline to day 1 of each of 8 cycles for each subscale of the Functional Assessment of Cancer Therapy (FACT)-Taxane v4.0.

A total of 98% of patients completed FACT-Taxane at baseline; scores for neuropathy and pain were well balanced. During follow-up or at treatment completion, 94% completed FACT-Taxane. They found a significant treatment effect favoring nab-paclitaxel for patient-reported peripheral neuropathy (P<0.001), neuropathic pain in the hands and feet (P<0.001) and hearing loss (P=0.002) through 8 cycles of treatment and at the final evaluation.

Dr. Socinski reported that outcomes for neuropathy were consistent with physician assessment.

The International Symposium on Supportive Care in Cancer is sponsored by the Multinational Association of Supportive Care in Cancer and the International Society of Oral Oncology.


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