Results Announced for Ganetespib in NSCLC Trial

Share this content:
Results Announced for Ganetespib in NSCLC Trial
Results Announced for Ganetespib in NSCLC Trial

Synta Pharmaceuticals announced final results from the GALAXY-1 trial for ganetespib in patients with advanced non-small lung cancer (NSCLC) with adenocarcinoma histology most likely to benefit from second-line treatment. Ganetespib is a selective inhibitor of heat shock protein 90 (Hsp90), a molecular chaperone which controls the folding and activation of a number of client proteins that drive tumor development and progression.

GALAXY-1 was a randomized, multi-center study designed to identify patient populations that are most responsive to treatment with the combination of ganetespib and docetaxel. Co-primary endpoints of the study were progression free survival (PFS) in patients with elevated LDH (eLDH) and PFS in patients with mutant KRAS (mKRAS).

RELATED: Lung Cancer Resource Center

Prespecified stratification factor analysis has shown that the chemosensitive patient population, the patients diagnosed with advanced NSCLC more than 6 months prior to study entry, derived the most benefit with combination treatment. This chemosensitive population was selected for the ongoing Phase 3 GALAXY-2 trial.

For more information call (781) 274-8200 or visit

Related Resources

Related Slideshows

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs