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Could Cytostatic Drugs Unleash Antitumor Immunity in Lung Cancer?

The combination of trametinib and palbociclib induced attack by NK cells — but not killing — of xenograft lung tumors in lab animals.

Malignant Pleural Effusion Interventions: What Matters Most to the Patient?

Patients with malignant pleural effusion may care more about relieving symptoms such as dyspnea as opposed to achieving pleurodesis.

Is Real-World Evidence a Complement to Randomized Clinical Trials?

Use of real-world data has the potential to accelerate drug and device approvals in rare diseases and advance precision medicine initiatives.

Do Corticosteroids Diminish Immune Checkpoint Blockade Efficacy?

It is unclear whether the link between steroid use and immune checkpoint inhibitor outcomes could be causal or is simply just correlational.

Gene-Delivery Method Generates Immune Checkpoint Antibodies In Vivo

In mice, DNA-encoded plasmids generated sufficient in vivo expression of immune checkpoint antibody CTLA-4; DMabs may one day rival traditional mAbs.

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